The invention discloses a ginseng wine capable of tonifying qi and soothing nerves and a preparation method thereof. The ginseng wine is composed of the following raw materials in parts by weight: 4-6 parts of spatholobus stem, 2-4 parts of radix astragali, 6-8 parts of ginseng, 10-15 parts of Chinese yam, 6-8 parts of dried cherry tomato, 3-5 parts of cocoanut shell, 2-4 parts of Saussurea involucrata, 6-8 parts of flasem milkvetch seed, 10-15 parts of glutinous rice flour, 6-8 parts of short-stalk slender acanthopanax fruit, 10-15 parts of grain-filled raw rice, 2-4 parts of herba violae, 4-6 parts of composite nutrient powder, 6-8 parts of peanut juice, 3-5 parts of mulberry bark and 800-1000 parts of white wine. The ginseng wine is prepared by immersing the radix astragali, ginseng, Chinese yam and many other traditional Chinese medicines for tonifying qi. The ginseng wine is simple in preparation method and convenient to take, has the advantages of high safety, no toxic or side effect and favorable mouthfeel, has the effects of maintaining mental tranquility, tonifying qi, soothing the nerves, solidifying the qi desertion, nourishing the liver, improving eyesight, nourishing and caring the human body, enhancing the immunity, strengthening the stomach and promoting digestion, and can perform the function of regulating the somatic functions after being drunk for a long time.