36 results about "O-iodoaniline" patented technology

The invention discloses a polyquinazoline compound and its preparation method and application. The preparation method comprises the following steps: under the action of a catalyst and an alkali Multi-component polymerization reaction to obtain polyquinazoline compounds. The method of the invention has mild conditions, and the polymerization monomer is simple and easy to obtain. The polyquinazoline compound obtained in the invention has better solubility, processability and higher thermal stability, and has potential applications in the fields of metal ion detection and self-assembly.

The invention discloses a preparation method of a substituted 2,3-dihydroquinolone compound, comprising the following steps: adding a palladium catalyst, a ligand, a carbon monoxide substitute, an additive, N-pyridinesulfonyl-o-iodoaniline and an alkene into an organic In a solvent, the reaction is carried out at 100-120° C. for 24-48 hours. After the reaction is complete, post-treatment is performed to obtain the substituted 2,3-dihydroquinolone compound. The preparation method is simple to operate, the starting materials are cheap and easy to obtain, the reaction efficiency is high, and the substrate compatibility is good, and the 2,3-dihydroquinolone compound substituted by the 2-position aryl group and the 3-position alkyl group can also be synthesized through substrate design , which is easy to operate and broadens the practicability of this method.

The invention relates to the field of compound preparation, particularly a preparation method of a novel bactericide boscalid. The method comprises the following steps: in a polar aprotic solvent or high boiling solvent, carrying out Suzuki reaction on a palladium catalyst p-chlorophenylboric acid and o-acetaminobrombenzene in the presence of alkali and quaternary ammonium salt to obtain an intermediate product 4'-chloro-2-acetaminobiphenyl; and deprotecting the intermediate product in the presence of concentrated hydrochloric acid, and condensing with 2-chloronicotinoyl chloride. According to the method, the Pd(OH)2 / C is used as the catalyst to perform the Suzuki coupling reaction, and is recovered and reutilized many times; and thus, compared with the prior art, the method provided by the invention greatly saves the catalyst cost, is convenient for recovering the catalyst, and avoids using the high-cost raw material o-iodoaniline.

A preparation method of boscalid comprises following steps: o-iodoaniline and 2-chloronicotinyl chloride have a condensation reaction to produce an intermediate product 2-chloro-N-(2-iodophenyl)pyridine-3-formamide;2-chloro-N-(2-iodophenyl)pyridine-3-formamide which is not purified has a Suzuki coupling reaction with 4-chlorophenylboronic acid directly, and boscalid is produced. A Ni / C preparation method is provided, and Ni / C is taken as a catalyst for the Suzuki coupling reaction, so that the production cost is greatly reduced; further, production raw materials are available, the yield is high, and the preparation method of boscalid is applicable to large-scale industrial production.

The invention discloses a fluorescent probe for identifying thiocyanate and its preparation and identification method. The molecular formula of the probe is C 57 h 75 Br 3 N 4 . Its preparation method is to first mix tris(4-iodophenyl)amine and 4-pyridine boronic acid, then be dissolved in the mixed solution of dioxane and water to obtain product A; product A is placed in a nitrogen-protected environment, Add Pd(PPh 3 ) 4 and Na 2 CO 3 , stirred at 80-100°C for 10-20h, cooled to 20-30°C after the end, diluted with water, and then extracted to obtain product B; with anhydrous Na 2 SO 4 Dry product B, then spin dry the solvent, and purify by column chromatography to obtain product C as a yellow solid; dissolve product C in N,N-dimethylformamide, then add bromooctane, heat to 75-85°C, After reacting for 30-40 hours, diethyl ether was added to the reaction solution until it was completely precipitated, filtered with suction, the solid was washed with diethyl ether, and dried to obtain a fluorescent probe for recognizing thiocyanate. The probe of the invention can identify thiocyanate, and has the characteristics of sensitive identification, high selectivity, simple operation, no pollution and low cost.

The invention relates to a beta-naphthyl methyl substituted spiral bisoxazoline ligand, a synthetic method and an application. The ligand has the advantages of simple synthetic method, mild condition and applicability for industrialization production. The ligand has a spiral framework and a feature of a plurality of chiral centers, therefore the ligand has high catalytic activity and chiral induction effect and strong adjustment capacity in an asymmetric catalytic reaction of transition metals. Pyrrolidine derivants with various optical activities are prepared through high region selectivity and high enantioselectivity from allenoic and o-iodoaniline by the catalysis of the ligand. With the important biological activity, the pyrrolidine derivant has a better prospect of industry and medicine applications.

The invention discloses synthesis methods of a rhazimine tetracyclic skeleton. One of the synthesis methods adopts the following linear synthesis route: gamma-hydroxy-alpha,beta-unsaturated ester having a [3,3,1] ring system structure is adopted an initial raw material; a methanol group protects the hydroxyl group of allyl alcohol, and deconjugation alkylation is creatively used to achieve the migration of a double bond and construct a whole carbon quaternary carbon center; lithium tetrafluoroborate undergoes silicon deprotection and alkenyl ether structure hydrolysis; an aldehydic carbonyl group obtained by oxidizing a primary alcohol and o-iodoaniline undergo reducing amination, and a ketocarbonyl group is reduced; a secondary alcohol is oxidized; and the rhazimine tetracyclic skeleton is constructed through the alpha-position coupling of the carbonyl group. The other one of the synthesis methods adopts the following convergent synthesis route: a methyl-protected allyl alcohol structure and chloride connected with the o-iodoanide fragment undergoes deconjugation alkylation, and then intramolecular coupling is carried out to construct the rhazimine tetracyclic skeleton. The synthesis methods have the advantages of simple operating steps, low requirements of reaction conditions, and high-efficiency synthesis of the target compound.

The invention discloses 9-aza-bicyclo[3.3.1] nonane coupled iodine-rich compounds. A preparation method of the compound comprises steps as follows: 9-nitrogen(6'-amino)hexylamine-9-9-aza-bicyclo[3.3.1] nonane-3 alpha-alkylamidophenyl formate and a chloroacetyl triiodoaniline derivative are mixed in an organic solvent in the mole ratio being 1:(1.0-1.5) and subjected to a reaction at the room temperature under the catalytic action of cesium hydroxide for 20-30 h, and a product, namely, the 9-aza-bicyclo[3.3.1] nonane coupled iodine-rich compounds, is obtained. The invention also discloses an application of the 9-aza-bicyclo[3.3.1] nonane coupled iodine-rich compounds as a contrast medium for early diagnosis of breast cancer.