30results about How to "Process pollution is small" patented technology

The invention discloses a manufacturing technique for extracting, separating and purifying kilogram-grade scale high purity GM1 using fresh pig brain tissue as raw material, which is characterized in that large sized extraction pot and adsorption resin with large holes, DEAE Sephadex A-25 and silica gel layer are utilized to build a set of manufacturing technique. The invention has the advantagesof elimination of toxic solvent chloroform in mobile phase in traditional method, less pollution for whole process, simple process, low cost and applicability to industrialized production.

The present invention discloses an in-situ and inclusion polymerization process of preparing composite nano particle / epoxy resin material. The epoxy resin is biphenol A type epoxy resin; and the nano particle is nano SiO2, nano montmorillonite, nano TiO2, nano CaCO3 or nano ZnO. Via the in-situ polymerization and inclusion polymerization on the surface of nano inorganic particles, the inorganic nano particles with strong autoagglutination are dispersed homogeneously in epoxy resin matrix. The preparation process using water as solvent is simple, low in cost and less pollutant, needs no solvent recover equipment and is favorable to application in industry.

The present invention discloses a preparation method of N-alkyl pyrrolidine which is an intermediate used for the pharmaceutical and chemical materials. The method is that ammonia or organic amine aqueous solution is controlled at 30 DEG C, at the same time cis-1, 4-dihalogen-butylene and organic alkali or inorganic alkali solution is dripped within one to five hours, the pH value is controlled between 11 to 12, after dripping, the solution continuously reacts for one to ten hours under 30 DEG C to 100 DEG C to generate N-alkyl-3-dihydropyrrole; then organic inert solvent, the N-alkyl-3-dihydropyrrole and 5 percent of Pd / C catalyst are added into a high-pressure vessel to be heated to 30 DEG C to 100 DEG C to be led to H2O, the system pressure is controlled as 0.2 to 1.0MPa, and the N-alkyl pyrrolidine is generated after the reaction for two to twelve hours. The source of the materials of the present invention is abundant; the product has the high yield and good purity and is easy forpurifying; the requirement of required equipments is comparatively low; the present invention causes little pollution, is in favor of treating the three wastes and is easy for realizing the industrialized production.

The invention relates to a preparation method of 6-bromine-2-pyridine methyl formate. The preparation method comprises the step of catalyzing esterification reaction of 6-bromine-2-pyridine carboxylic acid by taking p-toluenesulfonic acid as a catalyst, to be specific, heating and fluxing absolute methanol, the 6-bromine-2-pyridine carboxylic acid and the p-toluenesulfonic acid for 2-8 hours under stirring, cooling to a room temperature after reaction is ended, rotary drying a reaction system, dissolving solids in an organic solvent, washing, drying, filtering, concentrating, recrystallizing a concentrated product by a mixed solvent to obtain the 6-bromine-2-pyridine methyl formate, wherein a preferable molar ratio of the 6-bromine-2-pyridine carboxylic acid and the p-toluenesulfonic acid is 1: (0.1-0.16). According to one embodiment of the invention, the 6-bromine-2-pyridine carboxylic acid is obtained through diazotization, bromination and oxidation of 6-amino-2-methylpyridine. The preparation method is few in side reaction and simple in aftertreatment and is suitable for industrial production; and the product is easy to separate and has high yield, high purity and good quality.

The invention relates to a preparation process of high-purity 4-chloro-2-pyridinecarboxylate hydrochloride, which comprises the following steps of reacting 2-methyl-4-nitropyridine-N-oxide taken as a starting raw material with hydrochloric acid to obtain 4-chloro-2-methyl-pyridine-N-oxide; then dripping phosphorus trichloride into an organic solvent, carrying out reaction for generating 4-chloro-2-methylpyridine, further adding potassium permanganate into water for carrying out oxidation reaction, thus obtaining 4-chloro-2-picolinate; and mixing the 4-chloro-2-picolinate with the catalytic amount of DMF (dimethyfumarate), dripping thionyl chloride, and finally carrying out esterification reaction with methanol so as to obtain the 4-chloro-2-pyridinecarboxylate hydrochloride. The total yield can be up to 36.8%, and the purity can be 99.8% according to the HPLC (high performance liquid chromatography) detection. The process has the advantages of being rich in raw material resources, small in whole process pollution, conductive to controlling three wastes and easy for realizing industrial production.

The invention relates to a preparation method of 7-bromo-4-hydroxy-3-quinoline carboxylic acid. The preparation method comprises that hydrochloric acid serves as a catalyst to catalyze 7-bromo-4-hydroxy-3-quinoline carboxylic acid (C1-3) alkyl ester for carrying out hydrolysis reaction, specifically, the preparation method comprises the following steps of: heating and refluxing 7-bromo-4-hydroxy-3-quinoline carboxylic acid (C1-3) alkyl ester, an organic solvent and 1-2 mol / L hydrochloric acid aqueous solution for 0.5-2 hours under stirring, and then filtering and washing filter cake to obtain 7-bromo-4-hydroxy-3-quinoline carboxylic acid. In an embodiment of the invention, 7-bromo-4-hydroxy-3-quinoline carboxylic acid (C1-3) alkyl ester is obtained by condensation and cyclization of m-bromoaniline and (C1-2) alkoxy methylene malonic acid bi(C1-3) alkyl ester. The preparation method is few in side reactions, simple in after-treatment, liable to separate the product, high in yield and high in product purity, so that the preparation method is suitable for industrial production.

The invention relates to a preparation method for a basalt fiber conveying belt, and belongs to the technical field of rubber products. The preparation method comprises the following steps: performing hydrochloric acid treatment, coupling agent treatment and plasma grafting and impregnation treatment on basalt fiber cloth; mixing natural rubber, synthesized rubber, an activating agent, an anti-aging agent, a reinforcement agent and a plasticizer to obtain a first section of mixed rubber; adding a promoter and a vulcanizer for mixing to obtain a second section of mixed rubber, and extruding the second section of mixed rubber to obtain a coverage rubber sheet; mixing the natural rubber, the synthesized rubber, the activating agent, the anti-aging agent, an adhesive, the reinforcement agent and the plasticizer to obtain a first section of mixed rubber; then adding the promoter, the vulcanizer and an adhesive RA for mixing to obtain a second section of mixed rubber, freshening after the second section of mixed rubber is stewed, and attaching the second section of mixed rubber and the basalt fiber cloth to obtain rubberized canvas; attaching the basalt fiber rubberized canvas layer by layer to obtain a framework, attaching the coverage rubber sheets to the upper surface and the lower surface of the framework to obtain a belt blank, and vulcanizing the belt blank to obtain the basalt fiber conveying belt. The conveying belt prepared by the preparation method is low in cost, light in mass, high in intensity, fatigue-resistant and long in service life; the conveying energy consumption can be greatly reduced.

The invention provides a comprehensive recovery method of tungsten and molybdenum from the slag of bismith smelting furnaces and bismith reverberatory furnaces, comprising the following steps: soaking the slag of bismith smelting furnaces and bismith reverberatory furnaces with alkali to obtain alkali leaching solution, oxidizing the alkali leaching solution with H2O2, adjusting the PH value withacid, then adding MgCl2 and (NH4)2CO3 to removing S<2->, SiO2, As and P for decontamination, extracting tungsten and molybdenum with N235 from the purified solution, washing the extract with water, back-extracting with ammonia water, concentrating and crystallizing the back-extracting solution and finally obtaining tungsten and molybdenum mixed oxides by roasting. The method has less pollution, strong adaptability, high tungsten and molybdenum recovery rate, and the tungsten recovery rate is more than 90% and the molybdenum recovery rate is more than 95%, thus reducing the production cost andproviding a new method for recycling tungsten and molybdenum simultaneously.

The invention relates to a preparation method of amorphous dasatinib, wherein the preparation method includes the steps: dissolving raw materials of various crystal types of dasatinib in an anhydrous organic solvent at the temperature of 60-100 DEG C, adding a cosolvent for helping dissolution, and thus obtaining a fully-dissolved dasatinib solution; carrying out spray drying on the dasatinib solution, carrying out cyclone isolation, and rapidly precipitating to obtain a dasatinib solid powder; drying the dasatinib solid powder under reduced pressure, removing the solvent, and thus obtaining the dasatinib amorphous product. Through testing, the prepared amorphous dasatinib has the moisture content generally less than 2%, and is nearly anhydrous dasatinib. The method is suitable for converting various crystal types of dasatinib into the dasatinib amorphous product having the residual solvent consistent with Chinese pharmacopoeia, and the preparation yield reaches up to more than 99%. Moreover, the method has the advantages of simple operation, less operation steps, less using solvent, small process pollution, low cost and the like, and is suitable for large-scale industrialized production.

The invention relates to a new preparation process of leflunomide, a medical raw material drug, which uses ethyl acetoacetate as a raw material to cyclize with hydroxylamine hydrochloride to obtain leflunomide. This process can not only better control the content of 3-methyl isomer and 4-trifluoromethylaniline in the leflunomide product, but also has a higher yield and is more concise. The process produces less industrial waste water and waste gas, is more environmentally friendly, and can effectively reduce production costs and corrosion of equipment.

The invention discloses a method used for extracting coconut oil from a coconut cake, and the steps are: one or more than two of cellulose, hemicellulase or papain are combined to make into enzyme water solution with which the coconut cake is mixed and stirred, kept warm, stirred with warm water and further grinded by a colloid mill; serous fluid obtained obtains thin coconut cream after going through tailings separation; the thin coconut cream goes through layers separation after placed stilly; a free oil layer, an emulsion layer, a serum layer and a precipitation bed are taken out respectively; the obtained free oil layer and the emulsion layer are mixed together to obtain oil emulsion mixture in which water and salt are added, and then the papain is added for continuing zymolysis and the salt is added for supplementing; the mixture is placed stilly to lead the free oil to float upward to get the coconut oil; the coconut oil is extract out, washed by water and filtered, and high-quality coconut oil with the water content less than or equal to 0.1 percent is obtained after going through vacuum drying. The invention has simple technique process, low production cost, high oil production rate, little pollution, high product quality and high comprehensive utilization value of byproducts.

The invention relates to a method for extracting high-purity scutellarin from breviscapin. The method comprises the following steps: the breviscapin raw material is extracted by using organic solvent, the filtrate is added with clarifying agent for coagulation and clarifying, the coagulated and clarified filtrate is absorbed by macroporous absorbent resin and is eluted with water, the water eluent is concentrated through a reverse osmosis membrane or nanofiltration membrane, the concentrated solution is added with the organic solvent for standing and precipitation, the sediment is filtered and collected, the aqueous solution of the organic solvent is added and stirred to be suspendible, and after standing a night, the sediment is filtered, collected and washed to be near-neutral with water to obtain the high-purity scutellarin after drying. The alkali is not used in the entire process, the clarifier is used for removing the water insoluble matter, the impurity removal is carried out by using the macroporous absorbent resin, the concentration is carried out by using the reverse osmosis membrane or the nanofiltration membrane, the scutellarin plant salt is prevented from being heated and degraded in water, the content of the prepared scutellarin can reach above 97 percent, the quality is stable, the process is simple and the pollution is little.

The invention discloses a preparation method of a 2-hydroxyl-4-substituted arone compound. A Bronsted-Lewis dual acidic ionic liquid is taken as a catalyst to catalyze 3-substituted phenolic ester to undergo a Fries rearrangement reaction. The Bronsted-Lewis dual acidic ionic liquid catalyst is a quaternary ammonium salt ionic liquid containing dual acidity, contains a Lewis acid site of copper ions or zinc ions and a Bronsted acid site of a sulfonic group. The Bronsted acid site of the sulfonic group takes the quaternary ammonium salt as a cation and adopts a sulfate radical as an anion. The dual acidic ionic liquid catalyst has strong catalytic activity, high reaction selectivity, and an ortho product with high yield and high purity can be obtained. The reaction aftertreatment is simple and safe, has less pollution, and the catalyst can be used repeatedly. Specifically, the raw material 3-substituted phenolic ester of the Fries rearrangement reaction can be obtained by reaction of 3-substituted phenol with an acylation reagent acyl chloride.

The invention discloses a sulfur / carbon composite material and a preparation method thereof. Nanometer sulfur is uniformly filled in a pore path of a carbon material in the sulfur / carbon composite material to form the nanometer sulfur particle / carbon composite material. The preparation method comprises the following steps of: (1) reacting an aluminum sulfide solution with a sulfur source to generate an aluminum polysulfide solution; (2) adding a surface active agent and the carbon material into the aluminum polysulfide solution, uniformly stirring the resulting product, placing the uniformly stirred solution in an ultrasonic cleaner to carry out ultrasonic oscillation, and heating the resulting product to cause the sulfur generated by decomposition to in situ deposit to the pore path of the carbon material to obtain the sulfur / carbon composite material. According to the sulfur / carbon composite material, a sulfur particle and a carbon particle are tightly bound, the application of the sulfur / carbon composite material as the positive material of a lithium sulfur battery facilitates the reduction of solution loss of an active substance and the inhibition of shuttle effect, aluminum sulfide is generated from the ammonia gas and the hydrogen sulfide, which are generated by the decomposition of the aluminum polysulfide, through a condenser to be recycled, the technical process causes little pollution, the preparation method is simple in technology, low in cost and short in time, sulfur content is high, controllable, and strong in repeatability, and the sulfur / carbon composite material is easy for mass production.