The invention belongs to the field of veterinary drugs, and discloses Pudilan Xiaoyan granules, a preparation method thereof and a product quality control method. The Pudilan Xiaoyan granules are prepared from the following raw materials: Mongolian dandelion herb, baical skullcap root, coptis root, bunge corydalis herb, indigowoad root, weeping forsythia capsule, gypsum and licorice root. The preparation method comprises the following steps: taking the raw medicinal materials, and preparing the raw medicinal materials into coarse powder respectively; adding ethanol into the baical skullcap root coarse powder to perform extraction for a plurality of times, performing filtration, combining filtrates, recovering the ethanol, and performing concentration to obtain a thick paste; adding water and a compound enzyme into the indigowoad root coarse powder, stirring uniformly, performing warm immersion for a plurality of times, performing filtration, combining filtrates, and performing membrane separation on the filtrates to obtain an indigowoad root aqueous extract; adding water into other raw medicinal material coarse powder, performing continuous countercurrent extraction in a boiling state, performing filtration, performing membrane separation on the filtrate to obtain a clarified solution, adding the indigowoad root aqueous extract, and performing concentration to obtain a thick paste; and mixing the thick paste with the baical skullcap root thick paste uniformly, adding auxiliary materials, mixing the materials uniformly, preparing granules, and performing drying to obtain the Pudilan Xiaoyan granules. The formula provided by the invention is reasonable, and high in absorptivity, can be added by virtue of drinking water, is convenient to use, greatly reduces labor intensity, and is beneficial for intensive and large-scale raising.