The invention relates to a manufacturing method of a hollow regenerated cellulose fiber. The manufacturing method comprises the following steps of: preparing a spinning viscose solution through working procedures of soaking, squeezing, grinding, aging, yellowing, dissolving, filtering and defoaming on cellulose pulp, then spinning, in the dissolving step out of the working procedures for the preparation of the spinning viscose solution, adding one or mixture of water-soluble vinylon, a denaturing agent and a crosslinking agent, and then spinning to prepare the hollow regenerated cellulose fiber, wherein the fineness of the hollow regenerated cellulose fiber is 2.22-3.33 dtex, the dry strength of the hollow regenerated cellulose fiber is 2.2-2.6 cN/dtex, the wet strength of the hollow regenerated cellulose fiber is 1.2-2.0 cN/dtex, the degree of hollowness of the hollow regenerated cellulose fiber is greater than or equal to 70%, and the dry elongation is 10-20%. The manufacturing method is simple to operate, does not need special processing technology or equipment, does not release gas in a spinning process, and solves the problems such as reduction of the end breakage rate in spinning. The produced hollow fiber not only has high degree of hollowness, but also cannot collapse or deform due to after finishing and machining.