The invention relates to a hydro-pneumatic spring suspension cylinder which mainly comprises an upper connector 1, a damping hole 2, a main piston 3, a cylinder barrel 4, a piston rod 6, a guide sleeve 7, a large nut 8, a lower connector 9, a lower seat 10, a cylinder 12, a floating piston 13, a sealing ring 15, an upper seat 16 and a one-way valve 17, wherein the piston rod 6 is of a hollow structure, and the guide sleeve 7 is arranged outside the hollow piston rod. A main oil chamber 18, an auxiliary oil chamber 11, a piston rod cavity oil chamber 5 and an air chamber 14 are formed inside the cylinder. The upper connector of the hydro-pneumatic spring suspension cylinder is connected with a frame, the lower connector is connected with an axle, an engineering vehicle can realize a wide-range lifting function, vibration reduction requirements under a severe road condition in the running process can be met, working condition adaptability and running smoothness of the vehicle are improved, and comfort of drivers and passengers is improved.