The invention relates to a high-pressure water-sand jet-flow paint remover for a plastic fender guard of an automobile. The high-pressure water-sand jet-flow paint remover comprises an electric control module, a high-pressure water jet-flow generation module, a sand mixing module, a jetting module, a workpiece loading module, a sewage collection treating module and a filtering module, wherein one end of the high-pressure water jet-flow generation module is connected with a filtering module, the other end of the high-pressure water jet-flow generation module is connected with the sand mixing module, one end of the jetting module is connected with the sand mixing module, the other end of the jetting module is connected with the workpiece loading module, one end of the sewage collection treating module is connected with the workpiece loading module, the other end of the sewage collection treating module is connected with the filtering module, and the electric control module is respectively connected with the sewage collection treating module, the sand mixing module, the jetting module and the sewage collection treating module and is used for outputting a control signal. The high-pressure water-sand jet-flow paint remover disclosed by the invention has the advantages of simple operation process, high paint removing efficiency, good effect, small labor strength, low cleaning cost and small environment pollution, and is suitable for paint removing operations of large-batch fender guards or other waste structural assemblies.