The invention discloses a compound feed for the breeding of gemstone perch and spotfish and a preparation method thereof. The compound feed contains fish meal, insect fermented protein, soybean meal, fermented cotton meal, fermented rapeseed meal, enzymatically hydrolyzed soybean protein, and corn Distiller's grain protein, rice bran, subflour, flour, soybean oil, zeolite powder, salt, calcium dihydrogen phosphate, choline chloride, glycine, alanine, betaine, DMPT, pine needle powder, hawthorn powder, L-carnitine, bile Acid, Yikang XP, curcumin, tea polyphenols, multivitamins, and multimineral salts; it is prepared through the steps of raw material crushing, gelatinization, granulation, and drying. The compound feed of the present invention improves the survival rate of gem perch and grouper, promotes their healthy breeding, improves the digestion and absorption and transformation of fat in fish, effectively prevents the occurrence of fatty liver, greatly reduces the accumulation of intestinal fat, and effectively improves the quality of gemstones. The accumulation of sea bass and grouper muscle increases the meat yield of finished gemstone sea bass and grouper, and improves the flavor.