The invention belongs to a mass production mode of bag cultivation of straw mushrooms by a mushroom bran waste medium of pleurotus eryngii, and relates to the fields of utilization of agricultural wastes and planting of edible fungi. Waste mushroom bran annually produced by the pleurotus eryngii creates a pollution source, and by using the characteristic that partial cellulose of the waste mushroom bran is decomposed by the pleurotus eryngii spawns into mycelium protein, manioc waste is added to the waste mushroom bran to prepare a large amount of low-price and easily-available compost. A traditional straw mushroom production mode is a bed type planting mode, a large amount of manpower is required when fermentation raw materials are loaded onto and unloaded from racks, and refermentation is required, so the traditional straw mushroom production mode is time-consuming, labor-consuming and energy-consuming. The invention provides the mass production mode of straw mushrooms capable of reducing manpower and energy consumption, shortening the mushroom production time, improving the yield and lowering the cost. The mass production mode comprises the following technical process: bagging the piled fermented compost, conducting sterilizing, inoculating and spawn running, after the bags are full of spawns, conducting sterilizing, opening the bags, placing bare mushroom sticks on a culture rack, conducting mushroom production management and conducting centralized collection. The mass production mode of bag cultivation of straw mushrooms by the mushroom bran waste medium of pleurotus eryngii has the advantages that refermentation is not needed, manpower is reduced, energy consumption is reduced, mushroom production is advanced, cost is lowered, and the like.