40 results about "Nanoelectrochemistry" patented technology

The present invention relates to methods for producing a patterned surface having nanoscale features. The present invention more particularly relates to tip-induced nanoelectrochemical oxidation methods for nanoscale patterning. The invention also relates to the nanoscale patterns produced thereby.

The invention relates to a method for assembling embedded polymer to prepare metal nanometer array electrode in water phase, belonging to nanometer electrode technical field. The invention assembles polythene pyridine-polystyrene embedded polymer in water phase, uses the static function between cation micelle and the metal nanometer particle with negative charge to prepare metal nanometer array electrode. The inventive method is simple which lead in organic solvent, repeatedly applied electrode surface, and reduced cost. The metal nanometer array electrode has better dispersion, improved transmission speed of electrode surface, and better catalysis ability on catechin. The surface of the prepared metal nanometer particle has same charge, applied in the preparation of other metal nanometer array electrode, and self-assemble multilayer membrane, to build complex multi-element nanometer structure, with significant benefit in the research and application of nanometer electrochemistry and biological sensor.

The invention discloses a nano electrochemical enzyme sensor for detecting trichloroacetic acid (TCA) or sodium nitrite (NaNO2) as well as a preparation method and application of the nano electrochemical enzyme sensor. A base electrode selected by the nano electrochemical enzyme sensor is a carbon ionic liquid electrode (CILE), a composite film composed of a magnesium metal-organic frameworks nanometer material (Mg-MOFs-74), gold nanoparticles (AuNPs) and muscle hemoglobin (Mb) is modified on the surface of the CILE, and a Nafion film is assembled on the surface of the composite film. The preparation method comprises the following steps: modifying the Mg-MOFs-74, performing electro-deposition on the AuNPs, assembling the Mb and Nafion film and the like. The nano electrochemical enzyme sensor capable of being used for detecting the TCA or NaNO2 is constructed in the invention, is capable of respectively detecting two target substances, is wide in detection range and low in detection limit, and can be used for determining samples containing the TCA or NaNO2.

The invention discloses a preparation method of an estradiol magnetic molecularly imprinted nanoparticle electrochemical sensing membrane. According to the preparation method, an estradiol magnetic molecularly imprinted polymer is obtained via preparation of a molecularly imprinted self-assembled solution, polymerization, and template molecule elution. The estradiol magnetic molecularly imprinted nanoparticle electrochemical sensing membrane is high in selectivity, response speed, sensitivity, stability, tolerability, and universality, and is capable of realizing high efficiency, sensitive, real-time detection of estradiol in composite matrix.

A method is provided for forming a NanoElectroChemical (NEC) cell. The method provides a bottom electrode with a top surface. Nanowire shells are formed. Each nanowire shell has a nanowire and a sleeve, with the nanowire connected to the bottom electrode top surface. A top electrode is formed overlying the nanowire shells. A main cavity is formed between the top electrode and bottom electrodes, partially displaced by a first plurality of nanowire shells. Electrolyte cavities are formed between the sleeves and nanowires by etching the first sacrificial layer. In one aspect, electrolyte cavities are formed between the bottom electrode top surface and a shell coating layer joining the sleeve bottom openings. Then, the main and electrolyte cavities are filled with either a liquid or gas phase electrolyte. In a different aspect, the first sacrificial layer is a solid phase electrolyte that is not etched away.

The invention belongs to the technical fields of bioelectrochemistry and biochip sensors and relates to an electrochemical biochip sensor array for mycobacterium tuberculosis 16SrDNA and for detecting mycobacterium tuberculosis and a preparing method thereof. Starting with molecular level detection of the mycobacterium tuberculosis 16SrDNA, Fe3O4@SiO2 composite nanometer particles and a nanometer Au structure material are adopted as mediators, a novel and functionalized nanometer electrochemical biochip superparamagnetism nano-detection microsphere sensor interface is designed, the mycobacterium tuberculosis is subjected to double enrichment extraction and purification detection, and the electrochemical biochip sensor array for rapidly detecting the mycobacterium tuberculosis is constructed. A clinical sample containing the mycobacterium tuberculosis is directly added into a magnetic reaction micropore. A mycobacterium tuberculosis 16SrDNA specific sequence can be subjected to double enrichment and biological stabilization through utilizing a capture probe labeled by the Fe3O4@SiO2 composite nanometer particles and a nanometer Au labeled detecting probe respectively. A high mycobacterium tuberculosis target molecule separating efficiency and high detection sensitivity are expected to be achieved by utilization of nano-detection microsphere superparamagnetism. In addition, target molecule "on-chip" separation is expected to be achieved through characteristics of the electrochemical biochip sensor array without the need of extra separating steps, thus largely simplifying operation procedures and shortening the detection time.

The invention discloses rime-shaped [Cu(INA)2] metal-organic framework / three-dimensional graphene coated carbon fiber composite microelectrode, an in-situ preparation method and an application. The composite microelectrode comprises three-dimensional graphene coated activated carbon fibers and rime-shaped [Cu(INA)2] metal-organic frameworks on the three-dimensional graphene surface layer, wherein three-dimensional graphene is loose and porous, and the rime-shaped [Cu(INA)2] metal-organic frameworks are uniformly deposited on the three-dimensional graphene surface layer. The preparation method of the composite microelectrode comprises steps as follows: the carbon fibers are subjected to electrochemical activation in mixed acid, graphene and spongy metal copper are sequentially electro-deposited, spongy metal copper is converted into the metal-organic frameworks in situ with an electrochemical anode stripping method. The provided method is simple and convenient to operate and environmentally friendly. The composite microelectrode has lower LOD (limit of detection) and higher detection sensitivity when applied to the field of nano electrochemical sensors, and has very broad application prospects.

The subject invention provides materials and methods for detecting Zika virus. Specific embodiments provide an electrochemical immunosensing device and the methods of making and using the same for detecting Zika virus with exceptionally low detection limit. In some embodiments, the immunosensing device is capable of detecting picomolar (pM) level of Zika virus present in a sample by employing immunosensors functionalized with Zika virus binding ligands such as monoclonal Zika virus antibodies and Zika non-structural proteins. In an exemplary embodiment, the immunosensing device can be integrated with microelectronics to be adopted as point-of-care sensing systems. Advantageously, technologies provided herein offer rapid, on-site biosensing methods for the accurate detection of diseases caused by Zika virus.

The invention discloses a preparation method of a nano electrochemical aptamer sensor for detecting stress-induced phosphoprotein. The method comprises a step of preparing a manganese-doped nickel-based metal skeleton compound Mn-MOF by adopting a solvothermal method, a step of dispensing a solution on a surface of a glassy carbon electrode GCE, and dispensing methylene blue end labeled single-stranded aptamer MB-DNA to construct an MB-DNA / Mn-MOF / GCE sensing interface, and a step of adding a stress-induced phosphoprotein STIP1, specifically binding the MB-DNA aptamer with the STIP1 to form anMB-DNA / STIP1 compound such that the MB-DNA is separated from the surface of the GCE and the MB oxidation current peak intensity is weakened, fitting a linear relationship between the MB current peak intensity and STIP1 concentration, and constructing the nano electrochemical aptamer sensor for detecting the STIP1. The method has the advantages of convenient operation, high sensitivity and good specificity and can be used as a new method for the quantitative detection of STIP1.

The invention discloses a method for preparing a nano-electrochemical aptamer sensor for detecting stress-induced phosphoproteins. A manganese-doped nickel-based metal framework compound Mn-MOF is prepared by a solvothermal method and drip-coated on the surface of a glassy carbon electrode GCE. , and then drop-coated methylene blue end-labeled single-stranded nucleic acid aptamer MB-DNA to construct the MB-DNA / Mn-MOF / GCE sensing interface. Adding the stress-induced phosphoprotein STIP1, the MB-DNA aptamer specifically binds to STIP1 to form a MB-DNA / STIP1 complex, which detaches MB-DNA from the surface of GCE and causes the peak intensity of MB oxidation current to weaken. The linear relationship between MB current peak intensity and STIP1 concentration was fitted to construct a nano-electrochemical aptasensor for detecting STIP1. The method of the invention is convenient to operate, has high sensitivity and good specificity, and can be used as a new method for quantitative detection of STIP1.

The invention discloses a ferricyanide composite electrode material preparation method and applications of the ferricyanide composite electrode material in detection of hydrogen peroxide, and relatesto preparation and applications of a nanometer electrochemical material. The preparation method comprises: mixing K3Fe(CN)6, a AgNO3 solution and a LiCl solution to obtain a Li3Fe(CN)6 precursor; andplacing an aniline monomer, the prepared Li3Fe(CN)6 precursor and treated grapheneized carbon nano-tubes in a hydrothermal kettle, carrying out a reaction, filtering, and drying to obtain the LiPB-Pan-PUCNTs composite material. According to the present invention, Li3Fe(CN)6 has the oxidation-reduction potential in the electric conduction potential range of PAn, such that the PAn array can rapidlytransfer the charge to the oxidation-reduction center of Li3Fe(CN)6; and the grapheneized carbon nano-tubes have advantages of excellent conductivity, large specific surface area and biocompatibility,such that the in-situ polymerization and mixing can improve the conductivity and the dispersibility of the composite material and can rapidly achieve the direct electron transfer to the electrode surface so as to correspondingly improve the response sensitivity to the hydrogen peroxide detection.

The invention relates to the field of nano electrochemical sensors and particularly discloses a chemically modified electrode for high-sensitivity nonyl phenol detection and a preparation method and application thereof. The modified electrode is an Ag2Se@AuNPs modified ionic liquid carbon paste electrode having high electrochemical activity. The modified electrode has high nonyl phenol determining sensitivity and good selectivity, is simple, convenient, cheap, good in stability and suitable for field detection. The modified electrode is the Ag2Se@AuNPs modified ionic liquid carbon paste electrode having the high electrochemical activity. The prepared chemical modified electrode is successively applied to accurate detection of nonyl phenol in an actual sample.

The invention provides a preparation method of a stainless steel middle frame and aluminum alloy die-casting plate structure. The preparation method comprises the following steps that (1) a stainless steel plate is subjected to CNC machining to be a stainless steel middle frame, and the stainless steel middle frame is subjected to nano-electrochemical corrosion treatment, so that nano holes with the diameter being 100-200 nm are formed in the surface of the stainless steel middle frame; (2) aluminum alloy die-casting is conducted, specifically, an aluminum alloy with the silicon quantity being 5%-10% is selected and subjected to casting through a die-casting machine and a die-casting mould to be formed into an aluminum alloy die-casting plate, and the aluminum alloy die-casting plate is subjected to nano-electrochemical corrosion treatment, so that nano holes with the diameter being 40-60 nm are formed in the surface of the aluminum alloy die-casting plate; (3) the stainless steel middle frame obtained in the step (1) and the aluminum alloy die-casting plate obtained in the step (2) are subjected to plasma welding treatment to obtain a stainless steel and aluminum alloy composite body; (4) the stainless steel and aluminum alloy composite body is subjected to nano injection molding machining; (5) a workpiece obtained in the step (4) is subjected to CNC machining treatment; and (6) a workpiece obtained in the step (5) is subjected to baking varnish, PVD and electrophoresis treatment.

The invention discloses a nano electrochemical enzyme sensor for detecting trichloroacetic acid (TCA) or sodium nitrite (NaNO2) as well as a preparation method and application of the nano electrochemical enzyme sensor. A base electrode selected by the nano electrochemical enzyme sensor is a carbon ionic liquid electrode (CILE), a composite film composed of a magnesium metal-organic frameworks nanometer material (Mg-MOFs-74), gold nanoparticles (AuNPs) and muscle hemoglobin (Mb) is modified on the surface of the CILE, and a Nafion film is assembled on the surface of the composite film. The preparation method comprises the following steps: modifying the Mg-MOFs-74, performing electro-deposition on the AuNPs, assembling the Mb and Nafion film and the like. The nano electrochemical enzyme sensor capable of being used for detecting the TCA or NaNO2 is constructed in the invention, is capable of respectively detecting two target substances, is wide in detection range and low in detection limit, and can be used for determining samples containing the TCA or NaNO2.

The invention discloses a nanometer cobalt hydroxide-graphene composite membrane, a preparation method and an application thereof. The composite film includes a bottom layer of graphene nanometer and a surface layer of nanometer cobalt hydroxide, the thickness of the bottom layer of graphene nanometer is between 4000nm and 6000nm, the thickness of the surface layer of nanometer cobalt hydroxide is between 50nm and 100nm, and the thickness of the nanometer cobalt hydroxide surface layer is between 50nm and 100nm. The surface layer of cobalt oxide is evenly deposited on the nano-graphene bottom layer. The preparation method comprises the following steps: uniformly dispersing graphene oxide in water, coating it on a sheet-shaped conductive substrate, and drying to obtain a nanometer graphene oxide film; forming a three-electrode system and depositing cobalt hydroxide on the nanometer surface by cyclic voltammetry Graphene membrane surface, dry. The method provided by the invention has the advantages of simple operation, environmental friendliness and the like. When the composite thin film provided by the invention is applied to the field of nanometer electrochemical sensors, the detection limit and detection sensitivity of specific substances can be significantly improved, and the application prospect is very broad.

The invention relates to the field of nano electrochemical sensors and particularly discloses a chemically modified electrode for high-sensitivity nonyl phenol detection and a preparation method and application thereof. The modified electrode is an Ag2Se@AuNPs modified ionic liquid carbon paste electrode having high electrochemical activity. The modified electrode has high nonyl phenol determining sensitivity and good selectivity, is simple, convenient, cheap, good in stability and suitable for field detection. The modified electrode is the Ag2Se@AuNPs modified ionic liquid carbon paste electrode having the high electrochemical activity. The prepared chemical modified electrode is successively applied to accurate detection of nonyl phenol in an actual sample.

The invention provides a method for preparing monodisperse flower-like gold / platinum hybrid nano-particles with different particle sizes. The method adopts a green chemical method to prepare the monodisperse flower-like gold / platinum hybrid nano-particles with the assistance of sodium citrate. The method is characterized in that gold nano-particles protected by the sodium citrate are taken as seeds, and flower-like platinum shells are further grown on the surfaces of the gold nano-particles so as to prepare the monodisperse flower-like gold / platinum hybrid nano-particles. The method has the advantages of simplicity and convenience, and provides an achievable way for synthesizing the monodisperse flower-like gold / platinum hybrid nano-particles with high quality and different particle sizes. The obtained monodisperse flower-like gold / platinum hybrid nano-particles with different particle sizes of between 6 and 35 nanometers can achieve important application in the fields of fuel cells, nanometer electrochemistry and the like.

A method for preparing a ferricyanide composite electrode material and its detection of hydrogen peroxide relates to the preparation and application of a nanometer electrochemical material. Will K 3 Fe(CN) 6 with AgNO 3 solution, LiCl solution mixed to obtain Li 3 Fe(CN) 6 Precursor; aniline monomer, prepared Li 3 Fe(CN) 6 The precursor and the treated graphenized carbon nanotubes were placed in a hydrothermal kettle for reaction, filtered, and dried to obtain LiPB-PAn-PUCNTs composite material. Li 3 Fe(CN) 6 have a redox potential within the conduction potential range of PAn, resulting in the PAn array being able to transfer charges quickly to the Li 3 Fe(CN) 6 redox center; grapheneized carbon nanotubes have excellent electrical conductivity, large specific surface area and biocompatibility, so their in-situ polymerization and mixing increase the conductivity and dispersion of the composite material, and can quickly realize the combination with The direct electron transfer on the electrode surface increases the response sensitivity to hydrogen peroxide detection accordingly.