The invention discloses a sludge biochemical treatment system. The sludge biochemical treatment system comprises a sludge treatment device, a sludge concentrating tank, a homogenizing conditioning tank, a neutralizing tank, a primary settling tank, an anaerobic tank, a first aerobic tank, a secondary settling tank, a secondary aerobic tank, a final settling tank, an air floating tank, a pressure filter and a monitoring tank; the sludge concentration tank, the homogenizing conditioning tank, the neutralizing tank, the primary settling tank, the anaerobic tank, the first aerobic tank, the secondary settling tank, the secondary aerobic tank, the final settling tank, the air floating tank and the monitoring tank are connected in sequence; the pressure filter is connected with the first aerobic tank; and the sludge concentration tank is connected with the anaerobic tank, the secondary settling tank and the final settling tank. The sludge biochemical treatment system further comprises a collecting tank that is arranged between the sludge concentration tank and the homogenizing conditioning tank. With the adoption of the sludge biochemical treatment system and method, mass production is realized, the sludge quantity is effectively decreased, the water content of a filter cake is reduced, the amount of added flocculating agents is lowered down, the energy consumption in production process is reduced, and circular processing can be carried out at a plurality of times.