The invention provides an organic electroluminescent device with the structure of a packaging layer. The packaging layer comprises an organic barrier layer and an inorganic barrier layer which are alternatively stacked. The material of the organic barrier layer is one from copper phthalocyanine, N,N'-diphenyl-N,N'-di(1-naphthyl)-1,1'-biphenyl-4,4'-diamine, (8-hydroxyquinoline)aluminum, 4,4',4''-tris(N-3-methylphenyl-N-phenylamino)triphenylamine, and 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline; and the material of the inorganic barrier layer is a mixture formed by mixing one from a titanium simple substance , a zirconium simple substance and a hafnium simple substance with one from zinc oxide, aluminum oxide and indium oxide according to a mass ratio of 1:9 to 3:7. According to the invention, the organic electroluminescent device can be effectively prevented from being corroded by active substances such as external water, oxygen and the like, and the service life of the organic electroluminescent device can be prolonged. The invention further provides a preparation method of an organic electroluminescent device. The preparation method is simple in process and low in raw material price, and can be easily prepared in a large area.