52results about How to "Has industrial practical value" patented technology

The present invention relates to the technical fields of organic chemistry and pharmaceutical chemistry, concretely discloses a synthetic method for a known compound tylosin. The synthetic method comprises the following steps: taking Azithromycin A as a raw material, the protected Azithromycin A can be obtained by Cbz-Cl and then oxidized through a modified Pfitznor-Moffat method, the protected ketone by Cbz can be obtained, ketone is reacted through Wittig-Horner, keto is conversed into alkenyl to obtain the protected alkene, the protected alkene is oxidized to obtain an epoxy compound protected by Cbz, the epoxy compound protected by Cbz is deprotected to obtain a deprotected epoxy compound under the catalysis of Pd / C, the deprotected epoxy compound is reacted with n-propylamine and is performed a ring-opening to obtain a tylosin crude product, the tylosin crude product and acid are carried out a salt forming and purifying, then tylosin can be obtained by resolving. The synthetic route is changed by the method of the invention, the super low-temperature is not employed in the route, and the tylosin enables the effective industrialization production.

The invention discloses a supported ruthenium catalyst and a preparation method thereof. The preparation method is characterized in that the preparation method comprises the following steps: 1, preprocessing a carrier with a soluble alkaline earth metal salt, wherein the mass of the soluble alkaline earth metal salt accounts for 0.1-20% of the mass of the carrier; and 2, dipping the alkaline earth metal salt processed carrier with a material which comprises a primary active component metallic ruthenium and an assisted catalytic component comprising one or several of Ni, Co, Pd and Pt, wherein the mass of the primary component metallic ruthenium accounts for 0.1-5% of the carrier, and the mass of the secondary component comprising one or several of Ni, Co, Pd and Pt accounts for 0.01-5% of the mass of the carrier. The catalyst of the invention is mainly applied to the selective hydrogenation process of an aromatic ring of an aromatic compound, wherein the aromatic ring of the aromatic compound has at least one alkyl group, one ester group, one hydroxyl group or an amino group and also has at least one C1-8 alkyl group. Compared with catalysts prepared with the prior art, the catalyst of the invention has the advantages of low cost, simple preparation method, high activity, good selectivity, high safety in the operation of the aromatic ring hydrogenation, realization of the operation of the aromatic ring hydrogenation under a low pressure, and good economy.

The present invention belongs to the field of bioengineering technology. The bacterium of the present invention is a kind of Torulopsis glabrata, WSH-, obtained with WSH-IP303 as starting strain and through NTG mutagenesis and breeding selection in culture medium with added acetic acid as replenishing carbon source. Compared with the starting strain, LQ307 has mush reduced pyruvate decarboxylase,and strong and stable pyruvate producing capacity. The yield of pyruvate reaches 46.2 g / L, 21% higher than that of starting strain when using acetic acid as replenishing carbon source and through shaking bottle culture for 48 hr; the yield of pyruvate may reach 68.7 g / L the glucose converting rate may reach 0.651 g / g through fermentation in a 5 L fermenting tank for 64 hr.

The invention relates to a method for synthesizing chiral ferrocene diphosphine ligand. The method comprises the following steps: ferrocene as a raw material is prepared into acetylferrocene through a Friedel-Crafts reaction; the acetylferrocene is prepared into N,N-dimethylamine ethyl ferrocene through reduction, esterification and amination; and the N,N-dimethylamine ethyl ferrocene is resolved by chiral acid to obtain chiral acid salt of R-N,N-dimethylamine ethyl ferrocene; the chiral acid salt of the R-N,N-dimethylamine ethyl ferrocene is analyzed to obtain optical pure R-N,N-dimethylamine ethyl ferrocene; the obtained R-N,N-dimethylamine ethyl ferrocene reacts with organic lithium base; dialkyl phosphonium chloride is added to the reactant to obtain 1-S-dialkyl phosphonium-2-R-N,N-dimethylamine ethyl ferrocene; and 1-S-dialkyl phosphonium-2-R-N,N-dimethylamine ethyl ferrocene further reacts with another dialkyl phosphonium to obtain chiral diphosphine ligand 1-S-dialkyl phosphino-2-R-dialkyl phosphino ferrocene. The method simplifies operation, has low production cost, and can be used for industrial production.

The invention relates to a preparation method of S-3-aminoquinuclidine dihydrochloride which is obtained by taking 3-aminoquinuclidine dihydrochloride as a raw material and carrying out resolving, salifying by resolving, recrystallizing, resolving, salifying, decoloring and crystallizing by concentration. The S-3-aminoquinuclidine dihydrochloride serves as an important raw material for preparing palonosetron. In the method, the 3-aminoquinuclidine dihydrochloride is taken as the raw material and is directly subjected to chiral acid resolution in proper solvent without derivation, with resolution ratio over 40% and optical purity over 98%. The method has simple synthetic method and low production cost, has total product yield over 35% and can be used for industrial production.

It is an L-leucine high-yield bacterium and the production of L-leucine with invoice method, belonging to biological engineering field. The invented bacterial is a corynebacterium glutamicum JH-27, using corynebacterium glutamicum ATCC13032 as starting strain, mutagenizing separately with diethyl sulfate, nitrosoguanidine and ultraviolet, adding separately analogue of branched chain amino acid into minimum medium and sulfaguanidine into complete medium and breeding to prepare, being an L-leucine high-yield bacterium resistant sulfaguanidine and branched chain amino acid, compared with starting strain, producing L-leucine with the strain and invoice method, it expresses the ability of accumulation of highly qualified L-leucine. Shaking flask and culturing JH-27 for 60 hours, the yield of L-leucine is 30-32 g / l. Fermenting in fermenter of 5L for 55 hours, the yield of L-leucine is 40g / l.

The invention discloses a preparation method of a cast nylon composite material with a high friction-reducing and anti-wear surface layer. The preparation method comprises the following steps of: preparing dispersive suspensoid by hexamethylphosphoramide, ultra-fine kaolin and toluene diisocynate in proportion; adding dispersive suspensoid and teflon micro powder to a caprolactam melt; initiating caprolactam anionic ring-opening polymerization through a sodium hydroxide-toluene diisocynate catalytic activating system; casting a reaction mass into a preheated and heat-preserved centrifugal rotating die under normal pressure; after the reacting and casting liquid is polymerized, solidified and formed, gradually cooling and demoulding, thus obtaining the cast nylon composite material with the high friction-reducing and anti-wear surface layer. The prepared cast nylon composite material has the characteristics that an inner matrix and an outer surface layer are different in structure and performance, so that the requirements on manufacturing and using various pulleys, idler wheels, rope wheels and guide wheels for a transportation mechanism, a hoisting device and mine equipment can be met.

The invention discloses an event extraction and processing method for case-following electronic files. The method comprises the following steps: step 1, acquiring required file data from a case-following electronic file circulation processing platform and storing the required file data into a database; 2, constructing an event trigger word dictionary, matching an electronic file event descriptionparagraph, and performing text preprocessing methods such as sentence segmentation, word segmentation and part-of-speech tagging; 3, event attribute extraction: combining dependency syntax analysis and a semantic role labeling method to obtain six event attributes including an applicant, a susceptor, a behavior, time, a place and a mode of an event; and step 4, event aggregation: aggregating the atomic events into topic events, combining similar topic events, and storing the topic events into an event database. According to the method, the problem that crime fact information is rapidly obtained by the case-following electronic file is solved, event extraction and organization can be more accurately carried out on crime facts, and the method is a basis for efficient and high-quality paper marking.

The invention relates to an asymmetric synthesis method for (S,S)-2,8-diazabicyclo[4,3,0]nonane. N-benzyl-butene imidodicarbonic diamide is taken as a raw material, in presence of a chiral squaramidecatalyst (III), the N-benzyl-butene imidodicarbonic diamide and N-para-toluene sulfonyl-N'-propylene imidogen hydrazine (II) are subjected to an asymmetric [2+4] addition reaction, and 8-benzyl-2-para-toluene sulfonamide-7,9-dioxo-(1S,6R)-2,8-diazabicyclo[4,3,0]-3-alkene nonane is obtained; through the steps of recrystallization, reduction, acid-catalyzed hydrolysis and reduction, the (S,S)-2,8-diazabicyclo[4,3,0]nonane is obtained. The synthesis method is simple, the yield of the asymmetric catalysis product is high, the enantioselectivity of the product through recrystallization can reach 90% or above, and the asymmetric synthesis method is mild in condition, simple to implement, low in production cost and capable of being used for industrialized production.

The invention discloses a preparation method for modifying a nanofiltration membrane by utilizing carboxylated nanocellulose crystals and belongs to the field of membrane material preparation. The invention aims to solve the technical problems of toxicity, high possibility of harm to human bodies and the environment and insufficient hydrophilicity of an additive in the modification process of theconventional nanofiltration membrane. The method comprises the following steps: preparing a water phase from carboxylated nanocellulose crystals and a piperazine solution, carrying out polymerizationreaction on the water phase and oil phase trimesoyl chloride at an interface, and drying the reaction product to obtain the carboxylated nanocellulose crystal modified film composite nanofiltration membrane. According to the preparation method, the hydrophilicity of the carboxylated nanocellulose crystals is utilized, the carboxylated nanocellulose crystals are wrapped in the carboxylated nanocellulose crystals while interfacial polymerization reaction is carried out through the properties of water and oil, and the prepared membrane composite nanofiltration membrane increases the water transmittance and has high desalination rate and dye removal rate.

The invention discloses a synthesizing method of 3-quininone hydrochlorate, which comprises the following steps: adopting 4-piperidine aminic acid as raw material; esterifying; proceeding N-hydrocarbonization through halogenated acetic ester; obtaining diester catalyzed by alkaline to do Dieckmann condensation; stripping ester in the condensed acid condition to obtain the product.

The invention relates to a polymer with a main chain containing phenylsilylene-propargyl-benzoxazole ring, which has a structural formula shown in the figure, wherein, R has the structural formula shown in the figure. A preparation method of the polymer comprises the following steps: under certain temperature and pressure, propargyl compound and phenylsilylene component, which are dissolved in solvent and contain the benzoxazole ring, are prepared by dehydrogenization coupled reaction in the presence of a catalyst. The molecular weight of the obtained polymer differs according to the mixture ratio of the raw materials, the sorts and the dosage of the solvent as well as the reaction temperature; the range of weight average molecular weight Mw is not specially limited and is measured generally within 850-1,000,000 (based on polystyrene) by gel permeation chromatography, with the preferable range being 1000-50,000. The raw materials of the polymer are easy to prepare, low in price and simple in technique. The high-temperature resistant polymer can be applied to matrix resins of advanced composite materials, high-temperature resistant adhesives and coating as well as precursors for preparing ceramics.

The invention discloses a method for improving the conversion rate of aniline in synthesis of diphenylamine. The method comprises the following steps: simultaneously introducing aniline and isopropanol into a reactor according to a ratio of 1: (0.4-0.6), and carrying out a reaction under catalysis of a beta zeolite molecular sieve, wherein the concrete reaction conditions are as follows: the reaction pressure is 1.5 to 6.0 MPa; the reaction temperature is 250 to 300 DEG C; and the volume space velocity of aniline is 0.1 h-1 to 0.5 h-1. According to the invention, through selecting a proper catalyst and optimizing reaction conditions, and on the basis of guaranteeing the reaction of synthesizing diphenylamine from aniline, the reaction of synthesizing isopropylamine from isopropanol can be performed in a certain extent, so two reactions are coupled, and the effects of improving the conversion rate of aniline and eliminating environmental pollution are achieved. Combined production of isopropylamine can be realized on an original device used for synthesizing diphenylamine from aniline, so the economy of the device is increased; and separation of an obtained product can be completed through conventional rectification, and industrial practical values are obtained.

It is an L-leucine high-yield bacterium and the production of L-leucine with invoice method, belonging to biological engineering field. The invented bacterial is a corynebacterium glutamicum JH-27, using corynebacterium glutamicum ATCC13032 as starting strain, mutagenizing separately with diethyl sulfate, nitrosoguanidine and ultraviolet, adding separately analogue of branched chain amino acid into minimum medium and sulfaguanidine into complete medium and breeding to prepare, being an L-leucine high-yield bacterium resistant sulfaguanidine and branched chain amino acid, compared with starting strain, producing L-leucine with the strain and invoice method, it expresses the ability of accumulation of highly qualified L-leucine. Shaking flask and culturing JH-27 for 60 hours, the yield of L-leucine is 30-32 g / l. Fermenting in fermenter of 5L for 55 hours, the yield of L-leucine is 40g / l.

The invention relates to a chemical raw material and a preparation process thereof and particularly relates to a method for increasing high-temperature reaction preparation efficiency of a complex inorganic color pigment (CICP). The invention develops a convenient and simple method for increasing high-temperature reaction preparation efficiency of a CICP in order to overcome defects of high temperature, long time consumption, high energy consumption and high dust content in the sintering preparation process of the traditional CICP. Due to the adoption of the method, the sintering temperature of the CICP can be effectively reduced, the sintering time can be shortened, the process energy consumption can be reduced, and the flying dust generated in the process can be relieved.

The invention discloses a preparation method of a biological packaging film based on bacterial nanocellulose. The bacterial nanocellulose obtained by fermenting gluconacetobacter xylinum screened by mutagenesis, starch, sorbitol and glycerol are used as basic raw materials; water is added for mixing to prepare a film forming solution, bioactive components are added after further gelatinization, and the biological packaging film is obtained after coating and airing. According to the invention, the BC dosage can be greatly reduced, the biodegradability and edibility of the film are maintained, and the biological function is enhanced; the prepared packaging film not only has good strength, tensile strength, biodegradability, antibacterial function and other biological activity functions, butalso has high cost performance and large food packaging application range, and lays a solid foundation for realizing commercial application of BC packaging films.

The present invention discloses a photocurable composition and uses of the photocurable composition as varnish and colored paint. The photocurable composition comprises at least a photoinduced alkali production agent represented by a general formula I, at least a polyisocyanate compound and at least a poly mercapto compound, wherein in the general formula I, R is C1-C8 alkyl, phenyl, C1-C4 alkyl and C1-C4 alkoxy substituted phenyl or a group defined in the specification, X is a straight bond, O or S, or R-X is defined in the specification, and n is 1 or 2. According to the present invention, the photoinduced alkali production agent having the specific structure is used, such that the UV lamp irradiation time required by the composition curing is short, the activity of the light-producing alkali is high, the alkali catalyzing is fast, the cross-linking curing is completed in a short time, the remarkably improved curing efficiency is provided, the application period is not affected, and the industrial practical value is provided.

The present invention belongs to the field of bioengineering technology. The bacterium of the present invention is a kind of Torulopsis glabrata, WSH-, obtained with WSH-IP303 as starting strain and through NTG mutagenesis and breeding selection in culture medium with added acetic acid as replenishing carbon source. Compared with the starting strain, LQ307 has mush reduced pyruvate decarboxylase, and strong and stable pyruvate producing capacity. The yield of pyruvate reaches 46.2 g / L, 21% higher than that of starting strain when using acetic acid as replenishing carbon source and through shaking bottle culture for 48 hr; the yield of pyruvate may reach 68.7 g / L the glucose converting rate may reach 0.651 g / g through fermentation in a 5 L fermenting tank for 64 hr.

The invention relates to an asymmetric synthesis method of L-carnitine. Acetyl chloride (II) generates ketene in situ at a low temperature under the catalysis of organic base, the ketene and 2-chloroacetaldehyde (I) are directly subjected to an asymmetric intermolecular [2+2] cycloaddition reaction without separation in the presence of Lewis acid and a chiral catalyst to obtain chiral lactone, andlactone (IV) is reacted with a trimethylamine solution to obtain L-carnitine with high enantioselectivity. The synthetic method is simple, the yield of asymmetric catalytic products is high, the enantioselectivity of lactone products is 95% or above, conditions are mild, operation is easy, the production cost is low, and the method can be used for industrial production.

The invention discloses an additive, an etching system and an etching method for an etching solution for copper catalytic etching of a silicon wafer; the additive comprises a metal complexing agent, an acidity regulator and water. The acidity regulator is selected from one or more of citric acid, acetic acid or phosphoric acid; the metal complexing agent is selected from one or more of ethylenediamine tetraacetic acid, salicylic acid or hexamethylenetetramine; and the etching system is prepared by mixing an additive and a copper catalytic etching solution. Compared with an etching solution without the additive, the etching solution obtained by the additive has the advantages that etching reaction conditions for etching and texturing a silicon wafer are milder, and the weight reduction rate of the silicon wafer is lower; the inverted pyramid spines on the surface of the prepared silicon wafer are reduced, the structure is more uniform and smoother, and the surface reflectivity of the silicon wafer can be further reduced; therefore, the technical scheme is especially suitable for the texturing process of the flaked silicon wafer in the future, and has industrial practical value.

The invention discloses a preparation method of a cast nylon composite material with a high friction-reducing and anti-wear surface layer. The preparation method comprises the following steps of: preparing dispersive suspensoid by hexamethylphosphoramide, ultra-fine kaolin and toluene diisocynate in proportion; adding dispersive suspensoid and teflon micro powder to a caprolactam melt; initiating caprolactam anionic ring-opening polymerization through a sodium hydroxide-toluene diisocynate catalytic activating system; casting a reaction mass into a preheated and heat-preserved centrifugal rotating die under normal pressure; after the reacting and casting liquid is polymerized, solidified and formed, gradually cooling and demoulding, thus obtaining the cast nylon composite material with the high friction-reducing and anti-wear surface layer. The prepared cast nylon composite material has the characteristics that an inner matrix and an outer surface layer are different in structure and performance, so that the requirements on manufacturing and using various pulleys, idler wheels, rope wheels and guide wheels for a transportation mechanism, a hoisting device and mine equipment can be met.

The invention provides a fermentation and separation purification method of L-leucine, and relates to the technical field of production of amino acids. According to the method, corynebacterium glutamicum and brevibacterium ammoniagenes are utilized for co-culture and production of L-leucine, and the method comprises the steps of activation culture, seed culture, fermentation culture and separationpurification of L-leucine. The fermentation culture and separation purification process for L-leucine is optimized, the yield of L-leucine is significantly increased, the generation of by-products isreduced, the fermentation time is shortened, the sugar acid conversion rate is increased, and the generation of a large amount of wastewater is avoided; a pretreatment liquid and a concentrated auxiliary are utilized, L-leucine and L-valine are effectively separated, the purity of L-leucine is significantly improved, and the method is simple and easy to control, low in cost, and has extremely-high industrial practical value.

The invention relates to an asymmetric synthesis method of (S, S)-2,8-diazabicyclo[4,3,0]nonane, using N-benzyl-butenedimide as raw material, and N-p-toluenesulfonyl-N`-propeniminohydrazine (Ⅱ) in the presence of chiral square amide catalyst (Ⅲ) through asymmetric [2+4] addition reaction to obtain 8-benzyl-2-p-toluene Sulfonamido-7,9-dioxo-(1S,6R)-2,8-diazabicyclo[4,3,0]-3-ene nonane, followed by recrystallization, reduction, acid-catalyzed hydrolysis, The reduction step affords (S,S)‑2,8‑diazabicyclo[4,3,0]nonane. The synthesis method of the invention is simple, the yield of the asymmetric catalytic product is high, the enantioselectivity of the product after recrystallization can be as high as 90%, the condition is mild, the operation is simple, the production cost is low, and it can be used in industrialized production.

The invention relates to a method for synthesizing chiral ferrocene diphosphine ligand. The method comprises the following steps: ferrocene as a raw material is prepared into acetylferrocene through aFriedel-Crafts reaction; the acetylferrocene is prepared into N,N-dimethylamine ethyl ferrocene through reduction, esterification and amination; and the N,N-dimethylamine ethyl ferrocene is resolvedby chiral acid to obtain chiral acid salt of R-N,N-dimethylamine ethyl ferrocene; the chiral acid salt of the R-N,N-dimethylamine ethyl ferrocene is analyzed to obtain optical pure R-N,N-dimethylamineethyl ferrocene; the obtained R-N,N-dimethylamine ethyl ferrocene reacts with organic lithium base; dialkyl<1> phosphonium chloride is added to the reactant to obtain 1-S-dialkyl<1> phosphonium-2-R-N,N-dimethylamine ethyl ferrocene; and 1-S-dialkyl<1> phosphonium-2-R-N,N-dimethylamine ethyl ferrocene further reacts with another dialkyl<2> phosphonium to obtain chiral diphosphine ligand 1-S-dialkyl<1> phosphino-2-R-dialkyl<2> phosphino ferrocene. The method simplifies operation, has low production cost, and can be used for industrial production.

A technology for manufacturing H-shaped spanner includes such steps as forging to obtain the raw blank of H-shape spanner with H-shaped handle, forging again to obtain the fine blank, and grinding. Its advantages are simple process and precise sizes.

The present invention relates to a kind of preparation method of reinforced modified carboxymethyl chitosan hydrogel, first prepare powdery 3-aminopropyl polyhedron oligomeric silsesquioxane, then add in the solution of carboxymethyl chitosan , and then add polyethylene glycol diglycidyl ether solution, stir evenly, transfer the solution into a mold, and place it in an electric heating constant temperature drying oven for constant temperature reaction for 1 hour to obtain enhanced modified carboxymethyl chitosan hydrogel. 3-aminopropyl polyhedral oligomeric silsesquioxane is covalently linked to carboxymethyl chitosan and uniformly distributed in the carboxymethyl chitosan hydrogel system, thereby enhancing the mechanical properties and thermal stability of the hydrogel sex.

The invention relates to an asymmetric synthesis method of L-carnitine. Acetyl chloride (II) generates ketene in situ at a low temperature under the catalysis of organic base, the ketene and 2-chloroacetaldehyde (I) are directly subjected to an asymmetric intermolecular [2+2] cycloaddition reaction without separation in the presence of Lewis acid and a chiral catalyst to obtain chiral lactone, andlactone (IV) is reacted with a trimethylamine solution to obtain L-carnitine with high enantioselectivity. The synthetic method is simple, the yield of asymmetric catalytic products is high, the enantioselectivity of lactone products is 95% or above, conditions are mild, operation is easy, the production cost is low, and the method can be used for industrial production.

The invention provides a method for producing L-leucine by fermentation and relates to the technical field of amino acid production. The method uses Corynebacterium glutamicum ACCC16522 as an L-leucine producing strain, and comprises steps of activation culture, seed culture, fermentation culture and L-leucine extraction. Generation of byproducts is reduced remarkably by adding sodium malate to afermentation medium, and by adding inositol to a fed-batch medium, the glucose-to-acid conversion rate is increased, and the fermentation time is shortened. According to the method, the output and theyield of L-leucine are increased substantially by optimizing the fermentation medium, culture conditions and process, the process is simple and easy to control, the cost is low, and the method has quite industrial practical value.

The invention relates to a preparation method of S-3-aminoquinuclidine dihydrochloride which is obtained by taking 3-aminoquinuclidine dihydrochloride as a raw material and carrying out resolving, salifying by resolving, recrystallizing, resolving, salifying, decoloring and crystallizing by concentration. The S-3-aminoquinuclidine dihydrochloride serves as an important raw material for preparing palonosetron. In the method, the 3-aminoquinuclidine dihydrochloride is taken as the raw material and is directly subjected to chiral acid resolution in proper solvent without derivation, with resolution ratio over 40% and optical purity over 98%. The method has simple synthetic method and low production cost, has total product yield over 35% and can be used for industrial production.