The invention discloses an externally applied medicine for treating rheumatism bone disease. The active ingredients of the medicine are prepared from the following traditional Chinese medicinal raw materials in parts by weight of daphne papyracea, rhizoma polygoni cuspidate, polygala fallax hemsl, radix et rhizoma rhei, herba lycopi, radix angelicae, asarum heterotropoides, radix et rhizoma tripterygii, herba menthae, rhizoma chanxiong, myrrha, pine pollen, radix saposhnikoviae, caulis trachelospermi, radix zanthoxyli, cortex eucommiae, caulis spatholobi, rhizoma coptidis, xanthium sibiricum,galla chinensis, radix clematidis, rhizoma corydalis, white snake skin, folium artemisiae argyi, cortex acanthopanacis, flos carthami, radix angelicae sinensis, caulis spatholobi, radix angelicae pubescentis, long-noded pit viper and hippocampus kelloggi. The medicine has the effects of promoting blood circulation to remove meridian obstruction, eliminating swelling, relieving pain, and eliminating blood stasis and removing dampness, and is ultra-strong in seepage force by penetrating into the deep skin tissues to generate local heating phenomenon, getting through hindered meridian and accelerating blood circulation, dispersing swelling and expelling blood stasis, and repairing local damaged tissue to achieve rapid pain relieving effect, and is less in dosage, quick in effect, obvious in curative effect, and suitable for rheumatism, hyperosteogeny, cervical spondylosis, cervical and lumbar spinal stenosis and other diseases; and the preparation process is simple and feasible, and the medicine is suitable for popularization and application.