The invention provides a manufacturing process of a large pressurized vessel pipe plate forging, and belongs to the field of large forging heat treatment processes. The manufacturing process of the large pressurized vessel pipe plate forging comprises the concrete steps of carrying out forged heat treatment, forging, and carrying out heat treatment after forging. The process provided by the invention is mature, and conveniently solves the problems that during a production process, forging is easy to occur, the acceptability is lower, and the internal deformation is nonuniform. The steps of heat treatment after forging comprise pretreatment, isothermal bainite treatment for the first time, pre-heat treatment for the first time, normalizing treatment for the first time, bainite treatment forthe second time, pre-heat treatment for the second time, normalizing treatment for the second time, bainite treatment for the third time, and hydrogen relief treatment, so that white points in the forging can be effectively removed, grains are refined, and the strength of the forging is favorably improved.