The invention discloses an optimization design method for a step stress accelerated degradation test based on a Bayesian theory, and is applied to the technical field of the accelerated degradation test. The optimization design method comprises the steps as follows: firstly, determining product performance degradation and acceleration models, and based on the historical data, giving prior distribution of model parameters; secondly, determining an optimization design space, and forming a test scheme set; thirdly, creating an expected utility function or an expected loss function, determining optimization goals, and based on a Markov Chain Monte Carlo method, determining optimization goal values of designs in the test scheme set; and lastly, finding the optimal test scheme by using a curve fitting method. According to the optimization design method, the shortcoming of high possibility of larger deviation due to the implementation of the traditional (local) test optimization design method when the values of the model parameters are supposed to be known is avoided, and the optimization scheme obtained in the implementation of the test optimization design when the prior distribution of the model parameters is given is more reasonable and more actual.