The invention discloses a medicine for treating vegetative nerve disturbance caused by chronic manganese intoxication. The medicine is prepared from fructus lycii, camellia japonica, flowers of Turnip, polygoni multiflori, seeds of Glycine max (L.) Merr, fruit of Fiverleaf Akebia, Uraria crinita Desy., radix Boehmeriae, Pimpinella thellungiana, Niglla glandulifera Freyn et Sint., rhizome of Kirilow Rhodiola, Arisaema erubescens (Wall.) Schott, fructus choerospondiatis, Pedicularis dauidii Franch, all grass of Orobanche coerulescens Steph., rhizome of Stachya geobombycis C. Y. Wu, dendrobium, Armillaria mellea, mulberries, Lysimachia longipes Hemsl., Polygonatum sibiricum Delar., roots and rhizome of Smilax riparia DC., Begonia wilsonii, Themedatriandra Forsk.Var.japonica(Willd.)Makino, divaricate saposhnikovia roots and radix astragali. The medicine has the advantages that the treatment effect is good, the aim of treating both symptoms and root causes is achieved by regulating bodies, the medicine is safe and free of toxicity, and vegetative nerve disturbance is not likely to relapse after being cured.