The invention discloses an antibacterial and health-care soft silk fiber fabric and a production process thereof. The fabric is prepared from 50% of mercerized wool fiber, 26.1% of polyester, 10% of soft silk fiber, 10% of viscose and 3.9% of Lycra fiber. The production process of the fabric comprises the following steps of dyeing process, spinning process, knitting process and after-finishing process. Soft, smooth, shrink-resistant and machine-washable mercerized wool and elastic polyester and Lycra fiber easy to wash, quick to dry and not prone to deformation are selected, meanwhile the antistatic, smooth and cool viscose and the health-care soft silk fiber having flexible luster, good moisture absorbing and releasing properties, bright dyeing property and excellent color fastness and drapability are also added, so that the produced fabric is friendly to the skin and smooth, has a health-care property, embodies the advantages of shrinkage resistance, machine washing and pilling resistance of the mercerized wool, also embodies softness, smoothness and warm keeping of the soft silk fiber, and can improve body microcirculation and improve body immunity and disease resistance.