The invention discloses a fireproof manmade quartz stone slab with superhardness and a manufacturing method of the fireproof manmade quartz stone slab. The manmade quartz stone slab is manufactured from the following components in parts by weight: 30-80 parts of 6-80-mesh calcined quartz stones, 30-60 parts of 325-mesh quartz powder, 5-10 parts of cullet, 10-20 parts of 50-100-mesh red-silica powder or quartzitic sandstone powder, 5-15 parts of 100-150-mesh kyanite powder or andalusite powder or sillimanite powder, 1-10 parts of 100-200-mesh zirconium silicate or yttria-stabilized zirconia powder, 5-10 parts of unsaturated resins, 0.3-0.5 part of auxiliary, and 0.3-0.8 part of pigment. According to the fireproof manmade quartz stone slab, the red-silica powder, quartzitic sandstone powder, kyanite powder or andalusite powder or sillimanite powder, and zirconium silicate or yttria-stabilized zirconia powder is added in a manufacturing process, so that the compressive property and the fireproof flame retardant performance of the manmade quartz stone slab are improved; meanwhile, by using the calcined quartz stones, the hardness of the manmade quartz stone slab is improved, so that the fireproof manmade quartz stone slab with superhardness is relatively wearproof, difficult to scratch and long in service life.