The invention discloses high-adhesion oxidation-resisting UV-curable ink and a preparation method thereof. The UV-curable ink comprises a low polymer, a reactive diluent, a photoinitiator, filler and an additive at a certain weight ratio, wherein the weight ratio of the low polymer to the reactive diluent is 5:3; the photoinitiator is compounded by two kinds of photoinitiators at the weight ratio being 1:1. The invention further discloses a preparation method of the high-adhesion oxidation-resisting UV-curable ink. The preparation method comprises the following steps: at first, weighing all the ingredients in a reactor according to the mass percent, uniformly mixing, placing the mixture into an oven for softening, at last, stirring and dispersing the softened liquid by a high speed disperser, controlling the fineness to 5-20 microns, and canning. The high-adhesion oxidation-resisting UV-curable ink prepared by the preparation method has the advantages that the adhesion force can reach 100%, the curing speed is 8-15 s, the solvent resistance is strong, the deinking phenomenon, caused by that a conventional PE bottle cap is soaked for 4 h in a 1,800 ppm concentrations of peracetic acid solution after being printed with UV-curable ink, and the temperature is controlled to be constant to be 90 DEG C, is overcome, and the sterilization requirements of environmental protection departments are met. The preparation method is simple and feasible, and easy to realize.