The invention provides a coal gasification supercritical carbon dioxide power generation system and method capable of realizing waste heat recovery. The system comprises an air separating device, a burner, a carbon dioxide turbine, a heat regenerator, a water separator, a first carbon dioxide supercharging device, a carbon dioxide recovery device, a waste heat recovery device, a coal gasificationdevice, a Kalina turbine, a Kalina heat regenerator, a first mixer, an ammonia separator, a second mixer, a high-pressure condenser and a gas-liquid separator. According to the system, coal gas is used as fuel, and total capture of carbon dioxide is realized through oxygen-enriched combustion; the carbon dioxide expands to the subcritical state in the turbine, and the expansion ratio is higher than that of supercritical carbon dioxide Brayton cycle, so that the turbine works more, and the cycle efficiency is improved; supercritical carbon dioxide cycle waste heat is recovered through Kalina cycle during bottom cycle, by the aid of change of the working medium concentration in the non-isothermal process and the cyclic process of the working medium phase change, the gasification process andthe heat release process of a heat source are well matched, the irreversible loss of the heat exchange process is reduced, and the waste heat utilization efficiency is improved.