3 results about "Oxido reduction" patented technology

The application provides an application of an APE1 oxidation-reduction function inhibitor in preparation of a medicine for preventing acute radiation enteritis. That is, the medicine prevents the ARE by inhibiting the APE1 to block the release of related inflammatory factors. The preferred inhibitor of the application is E3330. The application is suitable for administration before or during radiotherapy, and provides a new target and strategy for ARE prevention.

The invention discloses a redox chaperonin PDX mutant for improving steroid hydroxylation catalysis activity of cytochrome P450 and application, according to the PDX mutant provided by the invention, the efficiency of OlePM for catalyzing LCA to generate UDCA is remarkably improved, mutants such as Y34I, Y34S, Y34E, Y34H, R67G, R67D, R67A, R67S, I90L, I90M, I90E, I90V and I90S are excellent in performance, and the UDCA concentration can reach 0.13-0.21 g / L and is improved by 5-8 times compared with that reported in literatures. By improving the electron transfer efficiency of the redox chaperonin, the steroid hydroxylation performance of the cytochrome P450 is remarkably enhanced, a new biocatalyst is provided for efficient and green biosynthesis of UDCA, and the method has important industrial application value.

A method for direct decarboxylative iodination of alkyl carboxylic acids by photo-oxidative reduction / copper co-catalysis relates to the field of organic compound synthesis. The method is to add alkyl carboxylic acid, iodine reagent, N-hydroxy phthalimide compound, alkaline substance, ligand, copper catalyst, photocatalyst and olefin additive into a solvent under an argon atmosphere, to produce an active ester intermediate in situ under the driving of visible light, and then to occur free radical-mediated decarboxylative iodination to synthesize a series of alkyl iodides. The reaction condition is mild, the operation is simple, has a wide substrate range and good functional group tolerance. The method can realize the late-stage modification of complex natural products and drug molecules, further proving the practicability of the method. The method uses stable, low-toxicity, cheap and easily available alkyl carboxylic acid to directly realize the synthesis of alkyl iodide, without the need for additional steps to pre-activate it, and is more in line with the concept of modern green chemistry.