70results about How to "Broaden design ideas" patented technology

The invention relates to a reduced response camptothecin prodrug monomer as shown in a formula I, reduced response camptothecin polymeric prodrug amphipathic molecules of the reduced response camptothecin prodrug monomer, and a preparation method and application of the reduced response camptothecin prodrug monomer and the reduced response camptothecin polymeric prodrug amphipathic molecules. In the formula I, each i is 2 or 3 independently, each X is O or NH independently, and R is H, CH3 or CH2CH3. According to the preparation method, raw materials including camptothecin, triphosgene and the like are used for modifying 20 bits of hydroxyls of camptothecin to prepare a camptothecin prodrug monomer containing disulfide bonds, then the camptothecin prodrug monomer is subjected to high-conversion-rate polymerization by using active free radical polymerization method to obtain an amphiphilic polymer which contains a camptothecin drug repetitive unit and has an extremely high drug loading capacity (more than 50wt%), and in a tumor cell reducing environment, a side chain disulfide bond is broken to perform molecular rearrangement and release camptothecin prodrug molecules, so that the amphiphilic polymer has characteristics of a reduced response controlled-release raw drug. The polymeric prodrug amphipathic molecules improve the water solubility and stability of the drug and have a controlled release characteristic.

The invention disclose a wheel blocking hydraulic station of a rotary kiln, which comprises a control valve group, a return oil filtering device, a pump device, a heater, a liquid level control device, an oil temperature control device and an oil tank, wherein the control valve group, the return oil filtering device, the pump device, the liquid level control device and the oil temperature control device are mounted on the top of the oil tank; the heater is arranged on the side wall of the oil tank; the control valve group is connected with the return oil filtering device through a pipeline; the control valve group and the return oil filtering device are connected with the pump device through pipelines respectively; the liquid level control device is arranged on the pump device; and the hydraulic station is provided with a combined speed regulating loop of an inlet oil line speed regulating loop and a bypass oil line speed regulating loop. The wheel blocking hydraulic station of the rotary kiln disclosed by the invention not only provides a control loop which is available for super-low-speed steady running for the fluid design field, even more important, expands the design idea of super-low-speed steady running. The wheel blocking hydraulic station of the rotary kiln can be applied not only to speed control of a rotary kiln for producing powdered products but also to other occasions available for super-low-speed running.

The invention discloses an asynchronous motor seat. The asynchronous motor seat comprises a fan cover, a motor seat body, and a front end cover close to a motor output shaft, wherein the fan cover is located at one end of the motor seat body, the front end cover is located at other end of the motor seat body, a plurality of heat-dissipation ribs are arranged on the motor seat body, each heat-dissipation rib is parallel with the axis of the motor output shaft, an integrally formed strip-type plate is arranged at the top ends of every two adjacent heat-dissipation ribs, and the motor seat body, the plurality of heat-dissipation ribs and a plurality of the strip-type plates form a tubular passageway with a special-shaped cross section. By means of the structure, the asynchronous motor seat can reinforce the heat-dissipation capacity after use, effectively improves the heat-dissipation situation, further effectively lowers the temperature rise of a motor, provides an effective technical scheme for temperature rise control in the development process of motors, widens the design thought of the motor, and lowers manufacturing cost.