The invention discloses a method for rapidly preparing large-area surface-enhanced
Raman scattering substrate. The method comprises the steps that 1, light solidification glue is prepared on a transparent substrate; 2, the transparent substrate with the light solidification glue is arranged on the upper portion of a target material, a
laser pulse penetrates through the transparent substrate and the light solidification glue and then is focused on the target material surface, and the target material absorbs the
laser pulse and then generates nano-particles which is deposited on the light solidification glue surface; 3, the light solidification glue is cured through
exposure, and then the deposited nano-particles are fixed to the transparent substrate; 4, a
metal thin film is deposited on the nano-particles to form a
metal nanostructure, and the surface-enhanced
Raman scattering substrate is obtained. Accordingly, pulse
laser is used for directly depositing the nano-particles generated by the target material onto the transparent
substrate surface, the sizes of the nano-particles can be selected by regulating the distance between the target material and the transparent substrate, the
controllability is good, the large-area SERS substrate can be prepared in a low-cost, efficient and rapid mode, and the prepared SERS substrate is high in sensitivity, good in consistency and pure in background
signal.