The invention discloses a production process and a production device of a urea formaldehyde slow-release synergistic fertilizer. The process includes urea formaldehyde solution preparation, granulation, post-processing and other steps. The device includes a urea formaldehyde reaction tank; the urea formaldehyde reaction tank is connected with a buffer tank through a urea formaldehyde pump, and the buffer tank is successively connected with a granulator, a dryer, a cooler, a screening machine, a coating machine and a packaging machine. The production process and the production device have the advantages that the process material is high in ball forming rate, and the liquid phase is less, so that the drying load is relieved, the productivity is improved, and energy consumption is reduced; and the urea formaldehyde slow-release synergistic fertilizer obtained through the process can meet nutrient demands of crops at different growth periods with one time fertilization, has quick-acting, intermediate-acting and long-acting nitrogen nutrients, can achieve the purpose of sustained or controlled release, is complete in nutrients, high in fertilizer efficiency, obvious in yield increasing effect and stable and lasting in fertilizer efficiency, has a soil improving effect, and also has the advantages of low water content, high particle strength, green environmental protection, and no residue.