The invention discloses an efficient printing ink cleaning agent and a preparation process thereof. The ink cleaning agent comprises disodium cocoamphoacetate, octadecyl dihydroxy ethylamine oxide, sodium dodecyl benzene sulfonate, ferulic acid, soybean saponin, sodium sulfonate, nonylphenol polyoxyethylene ether, thiourea dioxide, alpha-lipoic acid, sodium tripolyphosphate, isopropyl myristate, zinc naphthenate, methylisothiazolinone, diethylene glycol methyl ether, propylene glycol, ethyl alcohol and deionized water. The printing ink cleaning agent is good in stability, the decontamination rate of the printing ink cleaning agent for ink is as high as 90.4%-96.1% within 5 minutes according to tests, complete ink removal time is shorter than 430 seconds, removal efficiency is high, and the ink cleaning agent is free from corrosion and good in market prospect, does not damage printing machinery and consumables, can ensure good printing effects, and is quite suitable for serving as a special ink cleaning agent in printing industry.