The invention discloses a preparation process of a blood activating capsule, which comprises the following steps that: first, angelica and citrus aurantium extract the fat-soluble effective ingredient groups through a supercritical CO2 extraction process, the fat-soluble effective ingredient groups are included by Beta-cyclodextrin to prepare inclusion volatile oil, herb residue and astragalus, peach kernel, safflower and other six Chinese medicines are decocted, the filtrate is concentrated into clear cream A, ethanol is added in so that the ethanol content is 65 percent, supernatant is taken out and the ethanol is recovered, and clear cream B is prepared by concentration; and finally clear cream C is purified by macroporous resin enrichment, the clear cream C is heated, sterilized, dried by microwave to prepare dry cream, and the dry cream is mixed with rhizoma ligustici wallichii fine powder and the included volatile oil and starch, boiled and granulated, and the capsule is filled. The preparation process of the blood activating capsule has the advantages that the blood activating capsule prepared has safe and reliable therapeutic effect and stable and controllable quality, abandons the ineffective and harmful ingredients in the Chinese medicine raw material, improves the medicine purity and reduces the dose of a patient.