Relating to the technical field of synthetic leather functional additives, the invention discloses a water-based interface fusion agent suitable for synthetic leather. The water-based interface fusion agent is prepared from the following raw materials by weight: 10-15 parts of cold soluble type polyvinyl alcohol, 10-15 parts of cationic polyacrylamide, 5-10 parts of an oxidized polyethlene wax-hydrolyzed polymaleic anhydride graft copolymer, 3-5 parts of hydroxypropyl methyl cellulose, 3-5 parts of water-soluble modified crospovidone, 2-3 parts of polyethylene glycol 4000, 1-2 parts of activated clay, 0.5-1 part of polymeric aluminum sulfate, 0.5-1 part of hydrogenated palm oil, 0.3-0.5 part of tea seed powder, 0.1-0.3 part of sepiolite fiber, 0.05-0.1 part of bis(trifluoromethane sulfonimide), 0.05-0.1 part of ferrocene, and 100-150 parts of water. The interface fusion agent provided by the invention can effectively improve the polarity difference of a release paper surface and a slurry, reduces the surface tension of release paper, makes the slurry rapidly and uniformly fuse into release paper lines, thereby endowing synthetic leather with beautiful patterns and excellent surface quality, and meeting the use requirements of synthetic leather products.