The invention discloses health care wine with cream fragrance and a preparation method thereof. The health care wine with cream fragrance is prepared from the following raw materials in parts by weight: 40 to 60 parts of beautiful millettia roots, 30 to 50 parts of philippine flemingia roots, 10 to 30 parts of wolfberry fruits, 5 to 15 parts of macadamia shells, 10 to 20 parts of saccharose, 15 to 25 parts of corn steep liquor, 0.5 to 2 parts of citric acid, 250 to 350 parts of distilled water, 12 to 30 parts of brewer's yeast, 20 to 30 parts of herba epimedii, 1 to 5 parts of thelenota ananas, 2 to 5 parts of cranberries, 5 to 10 parts of hazelnuts, 20 to 30 parts of soybeans, 2 to 8 parts of radix achyranthis bidentatae, 5 to 10 parts of broccoli and 1 to 5 parts of garlic. The health care wine with the cream fragrance has the pleasant cream fragrance, and has the advantages that the effects of relieving fatigue, invigorating the circulation of blood, soothing the nerves, strengthening the body and improving the human body immunity are achieved, and the like.