35 results about "Anilinium chloride" patented technology

The invention discloses bovine serum albumin-platinum composite nanomaterial mimetic peroxidase as well as a preparation method thereof and application. Bovine serum albumin is used as a template, and the bovine serum albumin-platinum composite nanomaterial mimetic peroxidase is prepared through biomineralization. Bovine serum albumin-platinum composite nanomaterials are prepared through the following method that chloroplatinic acid aqueous solutions are added to bovine serum albumin aqueous solutions and are mixed, sodium hydroxide aqueous solutions are added to obtain mixed solutions, and water bath heating is carried out; ultrafiltration is carried out on the solutions, then the solutions are washed, and bovine serum albumin-platinum composite nanomaterial aqueous solutions are obtained. The bovine serum albumin-platinum composite nanomaterials have excellent peroxidase activity, and can catalyze hydrogen peroxide oxidation 3, 3', 5, 5'-tetramethyl benzidine hydrochloride to be in color development. Meanwhile, the mimetic peroxidase resists acid and base, high temperature and high salinity, and has excellent short-term indoor temperature stability and long-term indoor temperature stability.

The invention discloses a sulfur ion measurement method based on gold nanoparticles as simulated peroxidase. The gold nanoparticles act with sulfur ions to simulate the change of activity of peroxidase, and 3,3',5,5'-tetramethylbenzidine hydrochloride is oxidized by hydrogen peroxide in the presence of the gold nanoparticles as catalyst, and the color is developed to indicate the change of solution color and the change of ultraviolet absorption spectral characteristics. The detection limit of visual observation is 2 Mumol / L. The linear range of absorbance detection is 0.5-10 Mumol / L, and the detection limit is 0.08 Mumol / L. After the simple pretreatment of a water sample, the content of sulfur ions in the water sample is measured according to the method disclosed by the invention.

The invention discloses a high-substrate-affinity graphene-oxide-loaded nano-platinum mimetic peroxidase and a preparation method thereof. The graphene oxide is adopted as a stabilizer for controlling the generation of nano-platinum particles. The invention provides a novel composite nano-material preparation method. The preparation is simple and environment-friendly, high temperature is not needed, and surfactant is not needed. An average particle size of the obtained platinum nano-particles is 9.0nm. The preparation method has good reproducibility, and the obtained product can maintain stability for more than 4 months. The synthesized graphene oxide-nano-platinum composite material has good mimetic peroxidase activity, and can catalyzing 3,3',5,5'-tetramethylbenzidine hydrochloride oxidative coloration with hydrogen peroxide. The material has high affinity to the substrates 3,3',5,5'-tetramethylbenzidine hydrochloride and hydrogen peroxide. The material can be used for detecting low-concentration hydrogen peroxide. A catalysis product light absorbance is linearly related with hydrogen peroxide concentration within a range of 0.1-25mmol / L, and a detection limit is 0.03561mmol / L.

The invention discloses bovine serum albumin-platinum / bismuth composite nano material mimic peroxidase. A bismuth nitrate water solution is added into a bovine serum albumin-platinum nano material water solution; after the water solution is uniformly mixed with a phosphate buffering solution, the mixed solution is heated in a water bath; and ultra-filtration and water washing are carried out on the heated mixed solution to obtain the bismuth-bovine serum albumin-platinum composite nano material mimic peroxidase. The bovine serum albumin-platinum / bismuth composite nano material mimic peroxidase can be used for catalyzing hydrogen peroxide to oxidize 3,3',5,5'-tetramethylbenzidine dihydrochloride so as to develop the color; and the Michaelis constant on the 3,3',5,5'-tetramethylbenzidine dihydrochloride is 0.054mmol / L and the Michaelis constant on the hydrogen peroxide is 13.24mmol / L. Meanwhile, the mimic peroxidase has the advantages of acid and alkali resistance, high temperature resistance and high salt resistance, and has excellent room temperature stability.

The invention provides a process for preparing 3-benzyloxy-4-butylaniline hydrochlorides, which comprises using m-aminophenol as raw material, carrying out butanoylation reaction and Fries rearrangement, obtaining 2-butyryl-5-butyramidophenol, under the action of alkali, reacting 2-butyryl-5-butyramidophenol with benzyl halides, obtaining 2-butyryl-5-butyramidophenyl benzyl ether, hydrolyzing to obtain 3-benzyloxy-4-butyryl benzeneamine, finally carrying out Huangminglong reduction reaction to obtain 3-benzyloxy-4-butylaniline hydrochlorides.

The invention discloses a method for determining acid phosphatase based on chitosan-platinum simulated oxidase. The method is characterized in that acid phosphatase is utilized for hydrolyzing ascorbic acid phosphate to generate ascorbic acid so as to influence a catalytic chromogenic reaction system of chitosan-platinum simulated oxidase / 3,3',5,5'-tetramethyl benzidine hydrochloride, and ascorbic acid is directly used for determining the contents of acid phosphatase and an inhibitor thereof by combining with the change on the color of a solution and the characteristics of an ultraviolet absorption spectrum. The change value deltaA450 of absorbancy is in a linear relation with the concentration of acid phosphatase in a range of 0.25U / L-2.5U / L, and the detection limit is 0.0161U / L. The method is simple and convenient in operation and high in sensitivity and can be used as an analytical method for determining the contents of acid phosphatase and the inhibitor thereof in environment and life science systems.

The invention discloses an aniline black pigment producing method. The aniline black pigment producing method comprises the following steps of: taking aniline as a raw material, and adding hydrochloric acid to synthesize an aniline hydrochloride solution; adding a hydroxyl copper phosphate catalyst, and dripping hydrogen peroxide; and after reaction, filtering, cleaning, drying and grinding to obtain aniline black pigment. In the aniline black pigment producing method, dichromate is not taken as an oxidant, thus avoiding chromium pollution; the hydroxyl copper phosphate catalyst coordinates with the hydrogen peroxide oxidant, thus improving the yield of the aniline black pigment; the produced obtained aniline black pigment is pure in color and luster and is blue phase black; and the production is simple and convenient.

The invention discloses a sulfide ion detection kit based on bovine serum albumin-nano platinum / bismuth. Bovine serum albumin-nano platinum / bismuth reacts with sulfide ions and then simulates the change of peroxidase activity, 3,3',5,5'-tetramethyl benzidine hydrochloride is oxidized by hydrogen peroxide to develop a color under the catalysis action of bovine serum albumin-nano platinum / bismuth, and therefore changes of the solution color and ultraviolet absorption spectrum features are shown up. The linear range of absorbancy measurement is 0.08-4 micromol / L, and the detection limit is 50 nanomol / L. After a water sample is simply pretreated, the content of sulfide ions in the water sample can be measured well by adopting the method and the kit.

The invention discloses a method for preparing 3,3'-dichlorobenzidine hydrochloride through the rearrangement reaction of hydrogen chloride. By using an existing technique, ortho-nitrochlorobenzene is added into an organic solvent and alkaline liquor under the catalysis of a precious metal catalyst and a cocatalyst, and then the obtained object carries out a coupled reduction reaction with hydrogen, so that 2,2'-dichlorohydrazobenzene is obtained; and hydrogen chloride gas is fed into a 2,2'-dichlorohydrazobenzene solution dissolved by using an organic solvent to carry out a rearrangement reaction, so that 3,3'-dichlorobenzidine hydrochloride is obtained. The yield can reach over 95%, the reaction process can be intermittent, semi-continuous and continuous reaction processes, and the method is low in viscosity of reaction process, easy to uniformly stir and low in energy consumption, and has a yield higher than that in a traditional process, therefore, the method has a good industrialization prospect.

In particular, rizatriptan or a pharmaceutically acceptable salt thereof, which includes a) Preparation of the diazonium salt of aniline hydrochloride (II); followed by reduction and acidification to give the hydrazine (III); b) reaction in situ of the hydrazine hydrochloride (III) with α-keto-δ-valerolactone, to give the hydrazone (IV); c) Fischer indole reaction of the hydrazone (IV), to give the pyranoindolone (V), optionally followed by a hydrolysis reaction to give (VI); d) Transesterification of (V) or esterification of its hydrolysis product (VI), to give (VII), where R means straight or branched C1-C4 alkyl chain; e) Conversion of the hydroxyl group of (VII) into dimethylamino, to give the indolecarboxylate (VIII), where R has the meaning defined above; f) Saponification of the 2-carboalkoxy group of (VIII) to give indolecarboxylic acid (IX); and g) Decarboxylaton of the indolecarboxylic acid (IX) to give rizatriptan and, eventually, to obtain a pharmaceutically acceptable salt thereof. The invention also relates to synthesis intermediates to obtain rizatriptan.

The invention discloses a novel synthesis method of aromatic 5-chloro-2-fluoro-4-(trifluoromethyl) aniline hydrochloride containing a trifluoromethyl intermediate. The method comprises steps as follows: 1) 5-chloro-2-fluoroaniline, elemental iodine and the like are subjected to an iodination reaction in an anhydrous ethanol solution; 2) with dichloromethane as a solvent, an obtained aromatic iodination product is subjected to an acetylation reaction; 3) the aromatic iodination product protected by acetyl, methyl fluorosulphonyldifluoroacetate and the like are subjected to a trifluoromethylation reaction at the temperature of 80 DEG C; 4) finally, 6 mol / L hydrochloric acid is used for a deacetylation reaction in ethanol, and a target product is obtained. The novel synthesis method has the advantages that the route design is novel, the product purity is good and operation is safe, simple and convenient; all reactions are stably conducted in the solvent, the process is easy to control, few crude product impurities exist, purification is easy, and the quality and yield of the product are increased. The total yield of the route is 66%, the product purity can reach 98.5%, and the novel synthesis method has higher research and development application value.

The invention relates to a preparation method of a zinc ion battery positive electrode material and an electrode material prepared by the preparation method, the preparation method comprises the following steps: respectively dissolving sodium dodecyl benzene sulfonate and aniline hydrochloride in water to obtain a mixed solution system, wherein the concentration of sodium dodecyl benzene sulfonate is 0.01-1.0 mol / L, the concentration of aniline hydrochloride is 0.03-3.0 mol / L, and the molar ratio of sodium dodecyl benzene sulfonate to aniline hydrochloride is 1: (3-5); cooling the mixed solution system to 0-4 DEG C, adding an oxidizing agent, uniformly mixing, and standing for reaction to obtain stable polyaniline hydrogel, wherein the molar ratio of the use amount of the oxidizing agent to the use amount of aniline hydrochloride is 0.1-3.0; and washing the polyaniline hydrogel with water for multiple times, and freeze-drying to obtain a product polyaniline material. Based on the preparation method of the zinc ion battery positive electrode material, the preparation is simple, and the preparation cost is low; the prepared polyaniline hydrogel zinc ion battery positive electrode material has a complete nanofiber structure, and the cycling stability of the electrode material is improved.

The invention discloses a preparation method of a dye intermediate that is 3-acetamido-N,N-dimethylformamide. The method comprises the following steps: adding a mechanically applied mother solution and m-aminoacetanilide hydrochloride into a neutralization reaction kettle, heating, neutralizing with a sodium hydroxide solution to the reaction endpoint, and carrying out liquid-liquid sedimentationlayering within the temperature range after heating; separating lower-layer salt and mother liquor, performing filtration to remove the salt while the mother liquor is hot, and applying the obtained mother liquor in the next batch; carrying out nitrogen displacement on the upper-layer oil phase, heating the material, and dropwise adding ethylene oxide to carry out a hydroxyethylation reaction; andafter the hydroxyethylation reaction is finished, transferring the material to an esterification kettle, heating, then dropwise adding acetic anhydride to carry out an esterification reaction, and cooling to 35 DEG C after the reaction is finished, thereby obtaining an acetic acid solution of 3-acetamido-N,N-diacetoxyethylaniline. The method is simple in technological process, easy to operate andcontrol, low in wastewater generation, and low in energy consumption and material consumption. A dehydration process before esterification is omitted, so that the production machine-hour is greatly shortened.

The invention discloses a production method of m-aminoacetanilide, which comprises the following steps: 1, proportionally adding m-aminoacetanilide hydrochloride and mechanically applying a mother solution into a reaction kettle, heating the raw materials to 30-100 DEG C, and neutralizing the system with a sodium hydroxide solution until the reaction endpoint is 7-10; 2, performing liquid-liquid sedimentation layering within the temperature range of 40-100 DEG C, thereby preparing a lower-layer product and an upper-layer product; 3, separating salt from the mother liquor in the lower-layer product, filtering to remove salt while hot, and applying the mother liquor in the next batch; and 4, transferring the oil phase in the upper-layer product into a distillation kettle, and carrying out vacuum distillation dehydration to obtain a finished product with qualified water content, wherein the finished product can be directly used for synthesizing m-acetamido-N,N-dimethoxycarbonyl methylaniline. The method is simple in technological process, simple to operate and control, low in wastewater yield and high in total yield, and particularly, the dehydration and drying time of the product isgreatly shortened.

The invention discloses a preparation method of polyaniline / manganese dioxide electrode material with enhanced three-dimensional network structure. The preparation method reacts aniline hydrochloride, crosslinking agent and permanganate in polyvinyl alcohol aqueous solution to obtain polyaniline / manganese dioxide electrode material. In the preparation method of the invention, during the preparation of the electrode material, the polyaniline / manganese dioxide electrode material with a reinforced three-dimensional network structure is obtained due to the introduction of polyvinyl alcohol and a crosslinking agent. This enhanced three-dimensional network structure can not only overcome the expansion and contraction of polyaniline during charging and discharging, but also form a good protection for manganese dioxide, thereby improving the stability of electrode materials; and all raw materials only need to be added in sequence After the system is mixed evenly, it can be allowed to stand still for reaction. During the standing reaction, polyaniline is formed by oxidative polymerization while the oxidizing agent is reduced to manganese dioxide. The preparation method is simple and easy.

The invention discloses a solid-phase Fenton-like catalyst as well as a preparation method and application thereof, and belongs to the technical field of water treatment. The preparation process of the solid-phase Fenton-like catalyst disclosed by the invention comprises the following steps: preparing a neutral aniline hydrochloride solution, reacting aniline hydrochloride with polyacrylonitrile to obtain a solid product, dispersing the solid product in a solvent, and adding a copper source, thereby preparing the copper complex two-dimensional nitrogen-doped graphene-like coated zero-valent copper solid Fenton-like catalyst. The solid-phase Fenton-like catalyst disclosed by the invention has good catalytic activity, has relatively high catalytic activity in a solution with a pH value of 5-9, still keeps relatively high catalytic degradation capacity after being used for multiple times, and is suitable for wide application.

The invention discloses a folic acid - porous platinum - Graphene oxide composite nanomaterials and its detection of tumor cells , which is folic acid - porous platinum - Graphene Oxide Composite Nanomaterials Using graphene oxide as the substrate, folic acid molecules were cross-linked by amidation reaction, and platinum nanoparticles with porous structure were synthesized in situ to prepare a folic acid-porous platinum-graphene oxide composite nanomaterial. Folic acid-porous platinum-graphene oxide composite nanomaterials can specifically recognize folate receptors on the cell surface, and at the same time have the characteristics of mimicking peroxidase, which can catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine by hydrogen peroxide Hydrochloride color development. The color reaction can be used to quickly and sensitively detect the number of tumor cells, and the minimum detection rate can be as low as 30 MCF-7 cells. It can also catalyze diaminobenzidine to produce a reddish-brown precipitate on the cell surface for targeted detection.

The invention relates to a preparation method of nano-polyaniline. The preparation method comprises the following steps of: (1) taking hydrochloric acid or sulfuric acid and performing reaction with aniline to generate an aniline hydrochloride aqueous liquor or an sulfate sulfate aqueous liquor; (2) cooling the aniline hydrochloride aqueous liquor or the sulfate sulfate aqueous liquor to room temperature and atomizing; (3) mixing the atomized the aniline hydrochloride aqueous liquor or the sulfate sulfate aqueous liquor with chlorine dioxide gas and performing reaction of aniline hydrochloride or sulfate sulfate in atomized particles with chlorine dioxide to generate polyaniline; and (4) drying the polyaniline obtained the in the step (3) to obtain polyaniline particles. The method for preparing polyaniline provided by the invention is simple and convenient, and polyaniline is higher in purity with lesser chemical materials. Meanwhile, the polyaniline prepared is used as an antistatic agent, and the conductivity is 0.1-10S / cm. In the depositing process, attenuation of conductivity does not occur, and the nano-polyaniline is further good in compatibility with plastic.

The invention discloses a method for synthesizing 4-(1-amino-cyclopropyl)-aniline hydrochloride, and provides a feasible synthesizing scheme. In the method for synthesizing the 4-(1-amino-cyclopropyl)-aniline hydrochloride, [1-(4-nitro-pheny) propyl] benzyl carbamate is used as a raw material, multiple paths are tried, and a synthesizing path is optimized. The synthesizing path for 4-(1-amino-cyclopropyl)-aniline hydrochloride is mainly modified, and the feasible synthesizing method is provided.

The invention discloses a synthesis method for preparing m-aminoacetanilide hydrochloride from dinitrochlorobenzene, wherein the method comprises the steps: preparing dinitrochlorobenzene and an organic solvent into a dinitrochlorobenzene solution, then feeding the dinitrochlorobenzene solution and hydrogen into a reactor for reduction reaction, and carrying out gas-liquid separation on the reacted material to recover excess hydrogen for reduction reaction; distilling the liquid material after gas-liquid separation to separate out an organic solvent and water, and then carrying out acylation reaction with acetic acid and hydrochloric acid; recovering the organic solvent separated by distillation for preparing a dinitrochlorobenzene solution; and cooling the material obtained in the acylation reaction to obtain a supersaturated solution, crystallizing to separate out aminoacetanilide hydrochloride, carrying out solid-liquid separation, recovering the mother liquor to replace part or all of hydrochloric acid, and carrying out acylation reaction with the liquid material and acetic acid. According to the method disclosed by the invention, the characteristics of seamless connection, high efficiency and coherence of upstream and downstream processes are shown from raw material acquisition and reduction to acylation reaction, the whole reaction is simple and easy to control, medium materials are recycled, and the environmental protection pressure and cost are reduced.

The invention discloses a catalytic oxidation treatment method used for neutralization of wastewater with 3,3'-dichlorobenzidine dihydrochloride. The catalytic oxidation treatment method comprises following steps: 1, mixing and suction filtration, wherein waste alkali is added into wastewater for neutralization until the acid-base property of wastewater is adjusted to be weak acidity, and suctionfiltration is carried out so as to obtain a clarified solution; 2, catalytic oxidation, wherein an active carbon catalyst is introduced into a catalytic oxidation reactor, tap water, distilled water,or deionized water is added, a filtrate obtained in step 1 is mixed with tap water, distilled water, or deionized water at a certain ratio, an obtained mixture is pumped to the top of the catalytic oxidation reactor continuously so as to realize oxidation reaction at normal temperature, a part of oxidation wastewater obtained via reaction is recycled, is mixed with the filtrate at a certain ratio,and an obtained mixed solution is subjected to oxidation reaction in the catalytic oxidation reactor, and the left oxidation wastewater is subjected to biochemical treatment. The catalytic oxidationtreatment method is capable of destroying the structure of organic matters in wastewater effectively, and converting large molecular organic matters into small molecular organic matters with low biochemical influence, so that wastewater biochemical treatment is realized. The catalytic oxidation reaction is carried out at normal temperature, energy consumption is low; the technical process is simple; and the industrialization prospect is promising.

In particular, zolmitriptan or a pharmaceutically acceptable salt thereof, which includes a)Preparation of the diazonium salt of the aniline hydrochloride (II); followed by reduction and acidification to give hydrazine (III); b) In situ Reaction of the hydrazine hydrochloride (III) with α-keto-δ-valerolactone, to give the hydrazone (IV); c) Fischer indole synthesis of the hydrazone (IV), to give the pyranoindolone of formula (V); d) Transesterification of the pyranoindolone (V) to provide the compound (VI), in which R means a straight or branched C1-C4 alkyl; e) Conversion of the hydroxyl group of the compound (VI) into dimethylamino to give the indolecarboxylate (VII), in which R means a straight or branched C1-C4 alkyl; f) Saponification of the 2-carboalkoxy group of the compound (VII), to provide indolecarboxylic acid (VIII); g) Decarboxylation of the indolecarboxylic acid (VIII), to provide zolmitriptan and, eventually, to provide a pharmaceutically acceptable salt thereof.