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9 results about "Cis–trans isomerism" patented technology

Cis–trans isomerism, also known as geometric isomerism or configurational isomerism, is a term used in organic chemistry. The prefixes "cis" and "trans" are from Latin: "this side of" and "the other side of", respectively. In the context of chemistry, cis indicates that the functional groups are on the same side of the carbon chain while trans conveys that functional groups are on opposing sides of the carbon chain. Cis-trans isomers are stereoisomers, that is, pairs of molecules which have the same formula but whose functional groups are rotated into a different orientation in three-dimensional space. It is not to be confused with E–Z isomerism, which is an absolute stereochemical description. In general, stereoisomers contain double bonds that do not rotate, or they may contain ring structures, where the rotation of bonds is restricted or prevented. Cis and trans isomers occur both in organic molecules and in inorganic coordination complexes. Cis and trans descriptors are not used for cases of conformational isomerism where the two geometric forms easily interconvert, such as most open-chain single-bonded structures; instead, the terms "syn" and "anti" are used.

Process and apparatus for cis-trans isomerization of 4-halo-2-methoxyiminoacetoacetate esters

The present application relates to the technical field of organic chemical intermediates purification, in particular to a method and device for cis-trans isomerization conversion of 4-halo-2-methoxy imino acetoacetic acid ethyl ester. After cooling, 4-halo-2-methoxy imino acetoacetic acid ethyl ester is mixed with sodium chloride brine to form crystal slurry; then the crystal slurry is discharged into a crystal conversion kettle for aging; after aging, the crystal slurry is heated, extracted and centrifuged, and the organic phase is collected to obtain 4-halo-2-methoxy imino acetoacetic acid ethyl ester. Through the continuous process of "low-temperature brine crystallization enrichment-crystal conversion aging directional conversion-microwave rapid heating to prevent reverse conversion-two-stage extraction centrifugation purification-brine circulation to reduce cost", the content of cis-4-halo-2-methoxy imino acetoacetic acid ethyl ester is stably increased to 92-95%, and the production cost and environmental risk are reduced.
Owner:山东金城医药化工有限公司

A tetranuclear ring derivative and a method for preparing the same

The application belongs to the technical field of tetra-cyclic ring derivative preparation, and particularly relates to a tetra-cyclic ring derivative and a preparation method thereof. The preparation method of the tetra-cyclic ring derivative comprises the following steps: (1) adding two substrates, a photocatalyst and a solvent into a quartz tube and stirring; (2) placing the quartz tube under ultraviolet light to perform a photocatalytic reaction; and (3) evaporating the reaction liquid and separating the target compound through column chromatography. The application uses cis-olefin as a starting material to perform a cycloaddition reaction, has high regioselectivity and diastereoselectivity, effectively inhibits homodimerization of the olefin through a reversible cis-trans isomerization reaction, and thus efficiently obtains the tetra-cyclic ring derivative. The tetra-cyclic ring derivative prepared by the application plays a basic role in drug design and provides a solid structural support for a pharmaceutical molecule.
Owner:NORTHWEST UNIV

Cis-trans isomerization of oxytocin

Failures in establishing trust during international conflict negotiations frequently result in warfare, as ideological differences often cannot be resolved through rational discourse alone. Empathy between opposing parties is essential for building trust, and oxytocin is recognized for its critical role in facilitating empathy, trust, inter-brain synchrony, and cooperative decision-making. However, prevailing scientific studies typically do not differentiate between the cis and trans isomers of oxytocin, despite evidence that only the trans isomer is pharmacologically active. The present invention provides methods for the separation and quantification of oxytocin isomers, with particular emphasis on the trans isomer's function in social synchrony and decision-making within conflict negotiation contexts. Additionally, the invention explores the role of extremely low frequency electromagnetic radiation permeating the human central nervous system interconnecting neurochemical changes among groups. These advances clarify the unique neuropeptide functions of oxytocin and enhance understanding of its impact on cooperation and conflict resolution.
Owner:GOLDBERG JOEL STEVEN

Maleate cis-trans isomerase mutant, genetic engineering strain, method and application

The invention belongs to the technical field of enzyme engineering, and discloses a maleic acid cis-trans isomerase mutant, a genetic engineering strain, a method and application, the mutant is prepared by the following steps: by taking an amino acid sequence as shown in SEQ ID NO.1 as a parent sequence, mutating 124 alanine into valine to form a maleic acid cis-trans isomerase mutant A124V; the amino acid sequence of the maleate cis-trans isomerase mutant is as shown in SEQ ID NO.3, and the nucleotide sequence of the maleate cis-trans isomerase mutant gene is as shown in SEQ ID NO.4. The maleate cis-trans isomerase is mutated, the 124 site of the maleate cis-trans isomerase is mutated into valine, and the obtained mutant has better activity. The constructed maleic acid cis-trans isomerase mutant and fumarate synthase are subjected to coupled expression, the constructed genetically engineered bacterium takes maleate as a substrate, reaction is performed for 10-15 hours to produce L-malic acid, and the conversion rate can reach 99% or above.
Owner:NANJING NORMAL UNIVERSITY

3-thiotetronic acid derivative as well as preparation method and application thereof

The invention relates to a 3-thiotetronic acid derivative as well as a preparation method and application thereof. Specifically, the invention provides a compound as shown in a formula (I), and an optical isomer, a cis-trans isomer or a pharmaceutically acceptable salt thereof. The compound provided by the invention has obviously improved insecticidal and acaricidal activity, and can be used for developing novel crop insecticidal and acaricidal agents with low toxicity, high efficiency and environmental friendliness.
Owner:EAST CHINA UNIV OF SCI & TECH

Compounds containing an azobenzene structure and use thereof

PendingCN122356061ADiseaseEfficacy
This invention relates to a compound containing an azobenzene structure or a pharmaceutically acceptable salt, cis-trans isomer, tautomer, solvate, polymorph, or prodrug thereof; the compound provided by this invention is based on the original adenosine A... 2A Based on the structure of receptor antagonists, an azobenzene structure is introduced, making adenosine A... 2A Receptor antagonists possess light-controlled switching properties, and the compounds of this invention can act as adenosine A. 2A Receptor antagonists applied to adenosine A 2A In receptor-mediated diseases, the light-controlled switching properties of the compounds provided by this invention enable them to achieve local efficacy through light irradiation after systemic administration. Some compounds provided by this invention exhibit a fourfold increase in antagonistic activity under specific wavelengths of light irradiation, while others exhibit a fourfold decrease in antagonistic activity under specific wavelengths of light irradiation. In in vivo animal experiments, compound 1 provided by this invention significantly increases the motor ability of mice after light irradiation.
Owner:THE EYE HOSPITAL OF WENZHOU MEDICAL UNIVERSITY

Method and device for cis-trans isomerization conversion of 4-halogen-2-methoxyimino ethyl acetoacetate

The invention relates to the technical field of purification of organic chemical intermediates, in particular to a cis-trans isomerization conversion method and device for 4-halogen-2-methoxyimino ethyl acetoacetate. 4-halo-2-methoxyimino ethyl acetoacetate is cooled and then mixed with sodium chloride saline water, and crystal mush is formed; discharging the crystal slurry into a crystal transformation kettle for aging; and heating the aged crystal mush, extracting and centrifuging, and collecting an organic phase, so as to obtain the 4-halo-2-methoxyimino ethyl acetoacetate. According to the method disclosed by the invention, the cis content of the 4-halogen-2-methoxyimino ethyl acetoacetate is stably increased to 92-95% through a continuous process of low-temperature saline water crystallization enrichment, crystal transformation aging directional transformation, microwave rapid heating anti-reverse transformation, two-stage extraction centrifugal purification and saline water circulation cost reduction, and meanwhile, the production cost and the environmental protection risk are reduced.
Owner:山东金城医药化工有限公司

A MAT2A inhibitor, a pharmaceutical composition comprising the same and use thereof

Provided are MAT2A inhibitors, pharmaceutical compositions comprising the same, and uses thereof. Specifically, provided is a compound represented by Formula (I), or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, cis-trans isomer, solvate, polymorph, deuterated derivative, or a combination thereof, wherein each variable is as defined herein, and uses of the compound and pharmaceutical compositions comprising the same in the preparation of medicaments for the prevention or treatment of MTAP ‑ / ‑ related cancers.
Owner:SHANGHAI EUREGEN BIOPHARMA CO LTD