The invention discloses Qi tonifying and skin moistening soybean-chayote bread and preparation method thereof. The Qi tonifying and skin moistening soybean-chayote bread is prepared from the following raw materials in parts by weight: 1-2 parts of popcorns, 2-3 parts of soybeans, 2-3 parts of coffee beans, 0.5-1 part of rheum officinale, 0.5-1 part of radix puerariae, 0.5-1 part of gynostemma pentaphyllum, 100-110 parts of flour, 20-25 parts of chayote, 0.05-0.06 part of xanthan gum, 1-1.1 part of Arabic gum, 6-7 parts of white granulated sugar, 0.8-0.9 part of edible salt, 1.5-1.7 part of dried yeast, 2-3 parts of waxy corn starch, 2-3 parts of soybean protein, 5-6 parts of shortening, 6-7 parts of eggs, 4-5 parts of whole milk powder, and moderate ascorbic acid solution, raisin fermentation broth, fermented glutinous rice filtered rice which is fermented for 36h, salad oil and water. According to the preparation method, the soybeans and the popcorns are mixed and added into water to prepare pulp and then the pulp is filtered to obtain soybean milk, the coffee beans are smashed to obtain filter liquor, the filter liquor is combined with the soybean milk, the soybeans have the effects of tonifying the qi and moistening the skin, and the coffee beans are stronger in fragrance and better in taste after stir-frying.