71 results about "Methiodide" patented technology

The invention relates to the field of organic synthetic chemistry and specifically relates to a synthetic method of tulathromycin. No Cbz (carbamazepine)-Cl protection is used in the synthetic method of tulathromycin, which is provided by the invention; no Pd/C-H2 system needs to be used for deprotection; therefore, the operation is safer; besides, the reaction does not need to be carried out at an ultralow temperature, so that the energy source is saved; moreover, dimethylsulfide generated in the reaction process can be recovered and reused, so that the cost is relatively low; the reaction only comprises three steps, which is simpler than that in the known documents.

The invention discloses a method for preparing an intermediate of flutriafol bactericide, which comprises the following three steps: a first step, that is, dimethyl sulphide and dimethyl sulfate react in organic solvent to generate onium salt; a second step, that is, fluorobenzene and o-fluorobenzene formyl chloride are subjected to Friedel-Crafts reaction to generate 2, 4-difluoro diphenyl ketone; and a third step, that is, the 2, 4-difluoro diphenyl ketone and the onium salt react under alkaline condition to obtain the intermediate of flutriafol with high content. The method effectively controls the content of impurities in the intermediate of the flutriafol below 0.5 percent.

The invention discloses a synthesis method of an aromatic vinyl trifluoromethylthio ether compound, and belongs to the technical field of chemical synthesis. According to the synthesis method disclosed by the invention, the aromatic vinyl trifluoromethylthio ether compound is prepared by taking trans-nitro aryl ethylene as a substrate, silver trifluoromethylthio as a thioether reagent and copper trifluoroacetic acid as a catalyst, and adding an oxidizing agent and an additive. Raw materials used by the method are easy to obtain, the reaction is simple to operate, the yield is high, and the substrate universality is good; the obtained aromatic vinyl trifluoromethylthio ether product has important application in the medicine, pesticide and function material fields.

The invention provides a new synthesis method of 9-boron bicyclo (3,3,1)-nonane (9-BBN). 1,5-cyclooctadiene and borane are taken as raw materials, a reaction is carried out in a tetrahydrofuran solvent, and the 9-boron bicyclo (3,3,1)-nonane (9-BBN) is synthesized while yield is as high as 98%. The new synthesis method comprises the following steps of adding a smashed 4A molecular sieve, tetrahydrofuran, 1,5-cyclooctadiene and zirconium tetrachloride into a reaction flask, stirring for 1 hour, dropwise adding a dimethyl sulfide complex of borane at the temperature about 0 DEG C, carrying out a reflux reaction for 4 hours after dropwise addition is completed to obtain a product, cooling the obtained product to 0 DEG C and preserving heat for 3 hours, and filtering to obtain a 9-boron bicyclo (3,3,1)-nonane (9-BBN) solid product. The new synthesis method of the 9-boron bicyclo (3,3,1)-nonane (9-BBN) has the advantages of high yield, low cost, high product purity, easy operation, is beneficial to industrialization and has a good application prospect.

The invention discloses a novel preparation method of ulipristal acetate key intermediate 3,3,20,20-double (ethylenedioxy group)-5 alpha, 17 alpha- dihydroxyl-11 bata-[4-(N,N- dimethyl amidogen)- phenyl]-19-norprogesterone-9(11)-alkene, namely 3,3- ethylenedioxy group-17 beta-cyangroup female steroid-5(10), 9(11) diene-17 alpha-alcohol is used as a raw material, through the protection of hydroxyl, the addition of Grignard reagent and cyangroup, and the protection of ketal, and the target compound is obtained finally through 1,4 addition of alpha, beta unsaturation epoxide under the catalysis of a system of cuprous halides and dimethyl sulfide. The raw materials used in the method are safe and reliable, reaction is easy to control, reaction yield and stereoselectivity are high, and the method is applicable for industrial production.

The invention discloses a method for removing an odor organic gas, which is applicable to 2-dimethyl sulfide organic gas, thioalcohol organic gas, and thiophenol organic gas. The method comprises the following steps of: preparing a solvent mixture comprising an alcohol, and preparing an inorganic metal salt mixture from the solvent mixture and an inorganic metal salt mixture at the mass ratio of 1:0.02-0.08; starting stirring and introducing the odor 2-dimethyl sulfide organic gas, the odor thioalcohol organic gas, and the odor thiophenol organic gas into a container with an absorption solution; when the solution is saturated by absorption, distilling the absorption solution for recycling, and supplementing the inorganic metal salt mixture for recycling. The method disclosed by the invention is simple to operate, low in requirements for running equipment, and good in odor removal effect for the odor 2-dimethyl sulfide organic gas, the odor thioalcohol organic gas, and the odor thiophenol organic gas. The use amount of the inorganic metal salt is less, the solvent can be recycled, and finally, the black and odorless inorganic metal salt waste can be dehydrated and subjected to deep landfill treatment.

The invention relates to an efficient dye flocculant as well as a preparation method and an application thereof. The efficient dye flocculant is characterized being prepared from a polymer main chainPHAM (poly(hydroxymethyl acrylamide)), cationic polymeric side chain PDMC-COOH (polymethacryloxyethyltrimethyl ammonium chloride containing carboxyl at the tail end), anionic polymeric side chain precursor PtBMA-COOH (poly(tert-butylmethacrylate) containing carboxyl at the tail end), functional polymeric side chain precursor PNVF-COOH (poly(N-vinylformamide) containing carboxyl at the tail end), DMF (dimethylformamide) solvent, a catalyst, namely, NHS (N-hydroxysuccinimide), EDC.CH3I (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide), potassium hydroxide and CDTAD (cyclohexanediamine tetraacetic acid dianhydride), and the efficient dye flocculant is used for treating dye wastewater and artistic coating wastewater drained in the dye synthesis or dyeing and finishing process. The efficient dye flocculant has the advantages of being high in trapping capability and settling speed, capable of treating complexing heavy metal ions, trapping dye molecules and complexing heavy metal ions in a few seconds and growing into large settling particles rapidly to achieve the purpose of rapid dye separation, simple to operate, low in treatment cost, high in adaptability and the like.

The invention belongs to the technical field of heterocyclic chemistry, particularly relates to a heterocyclic anti-tumor chemical medicine, and more particularly relates to a synthesis method of pyrimidine heterocyclic ring-containing antitumor medicine molecule AZD6738. A chiral ligand induced asymmetric oxidation method is used, chiral ligands are combined with cheap oxidizing agents (such as hydrogen peroxide) to oxidize dimethyl sulfide to prepare chiral sulfoxide, conversion of the chiral sulfoxide is efficiently achieved, a chiral sulfoxide compound 7 for the AZD6738 is prepared, and then the final product AZD6738 is prepared through an intermittent reaction. Besides, the AZD6738 is prepared by adopting a fluid chemical method, the total yield of total synthesis of the AZD6738 is remarkably improved compared with that of an intermittent reaction, and the method is suitable for industrial production.

The invention discloses a synthesis method of (R)-5-methylpyrrolidone-2-one. The synthesis method comprises following steps: step one, adding methyl levulinate, borane dimethyl sulfide, and a catalystinto a solvent, and carrying out reactions for 1 to 5 hours to obtain (R)-4-hydroxylmethyl pentanoate; step two, adding (R)-4-hydroxylmethyl pentanoate obtained in the step (1) into a reactor, introducing a nitrogen source and Raney nickel into the reactor, and carrying out catalytic reactions under a pressurized condition to obtain (R)-4-aminomethyl pentanoate; step three, adding (R)-4-aminomethyl pentanoate into a solvent, adding an alkaline catalyst, raising the temperature to 30-80 DEG C, and carrying out reactions for 0.5 to 5 hours to obtain the target product (R)-5-methylpyrrolidone-2-one; wherein the solvent in the step (1) is one or more of dichloromethane, toluene, dimethyl formamide, dimethyl sulfoxide, dichloromethane, and tetrahydrofuran. The synthesis method has the advantages of easily available and cheap raw materials, high atom utilization rate, high purity, easy purification, and high yield, and the chiral center does not need to be splitted.

The invention belongs to the technical field of sewage treatment, and particularly provides a novel deodorization process for high-standard control of sewage plant odor. A ''biotrickling-vacuum ultraviolet/catalysis'' combined process is adopted to realize efficient removal of low-concentration hydrogen sulfide, ammonia, methyl mercaptan and dimethyl sulfide in the sewage plant odor. The process is simple, low in cost and beneficial to industrial application.

The invention discloses a methyl mercaptan purification device which comprises a multi-stage condenser, an extraction tower, a coalescer, a degassing tower, a methyl mercaptan rectifying tower, a dimethyl sulfide rectifying tower, a wastewater rectifying tower and a dimethyl sulfide conversion reactor. The multistage condenser is connected with the methyl mercaptan synthesis reactor, a lower gas phase outlet is connected with the synthesis tail gas condenser, a bottom liquid phase outlet is connected with the lower part of the extraction tower, the extraction tower is connected with the coalescer and the condenser, a bottom discharge hole is connected with the middle part of the wastewater rectifying tower, the coalescer is connected with the extraction tower, the degassing tower and the methyl mercaptan rectifying tower, a top outlet of the methyl mercaptan rectifying tower is connected with the mercaptan storage tank, a bottom outlet is connected with a middle feed port of the dimethyl sulfide rectifying tower, the dimethyl sulfide rectifying tower is connected with the dimethyl sulfide conversion reactor, and a top outlet of the wastewater rectifying tower is connected with a tail gas washer. The device is reasonable in technological process, high in product methyl mercaptan purity, low in operation energy consumption and sufficient in dimethyl sulfide utilization, and is anideal methyl mercaptan purification device.

The invention relates to a novel chelating heavy metal capturing agent, and a synthesis method and application thereof. The technical scheme is characterized in that a polymer main chain polyhydroxyethyl acrylamide, a functional polymer side chain precursor polymer carboxyl-terminated poly(N-vinylformamide), water, a catalyst N-hydroxysuccinimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide, potassium hydroxide, ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid dianhydride and carbon disulfide are employed for prepare the novel chelating heavy metal capturing agent, and the novel chelating heavy metal capturing agent is used to treat heavy metal wastewater discharged from electroplating, smelting, mining, beneficiation, chemical engineering and machinery. The functional group of the capturing agent can adsorb complexed heavy metal ions, and each basic unit can provide six coordination atoms for strong chelation and adsorption. Further, a chemical precipitation reaction between sodium dithiocarbamate at the side chain and a sedimentation aid is facilitated through a polymer brush, and a large aggregate is generated in seconds, so that rapid settling is realized and the operation is simple.

Provided herein are compositions including oxotremorine (e.g., oxotremorine methiodide or Oxo-M) and 4-PPBP (e.g., 4-PPBP maleate). Also provided are methods of treating a connective tissue defect in a subject with oxotremorine and 4-PPBP. In addition, provided are scaffolds and methods of making same that include multiple fibers that include Oxo-M, 4-PPBP, and optionally icariin or kartogenin.

The invention discloses a preparation method of nifuratel, which comprises the following steps: taking epoxypropyl dimethyl sulfide as an initial raw material, carrying out a synthetic reaction with carbon dioxide to obtain methylthio methyl ethylene carbonate, then carrying out a synthetic reaction with tert-butyl carbazate to obtain N-(tert-butyl formate-amino)-5-methylthio methyl-2-oxazolidinone, and finally, carrying out a reaction on the N-(tert-butyl formate-amino)-5-methylthio methyl-2-oxazolidinone and the N-(tert-butyl formate-amino)-5-methylthio methyl-2-oxazolidinone to obtain the nifuratel. And carrying out condensation reaction with 5-nitrofurfural to obtain nifuratel. The nifuratel prepared by the method is relatively high in yield and purity, the preparation process is green and pollution-free, meanwhile, the problem of carbon dioxide waste gas pollution is solved, and the defects of environmental pollution, potential safety hazards, raw material waste and the like existing in an existing nifuratel synthesis process are overcome.

The invention discloses a preparation method of a substituted benzo [B] naphthobenzene [2, 3-D] thiophene derivative, which comprises the following steps: reacting 2-naphthyl dimethyl sulfide serving as a raw material at low temperature to obtain an intermediate S-1, carrying out coupling reaction on the intermediate S-1 and substituted o-iodobenzene to obtain an intermediate S-2, and carrying out demethylation reaction on the intermediate S-2 under the action of Lewis acid to obtain S-3, 5-disubstituted benzo [B] naphthobenzene [2, 3-D] thiophene derivative. The S-3 is subjected to a ring closing reaction under the action of alkali, and the product W0: substituted benzo [B] naphthyl benzene [2, 3-D] thiophene derivative is obtained. By adopting the preparation method of the substituted benzo [B] naphthobenzene [2, 3-D] thiophene derivative provided by the invention, the obtained product is high in purity, high in yield and low in cost, no waste solvent is generated in the whole preparation process, and meanwhile, less waste water is generated, so that a foundation is laid for realizing the aim of environmental protection.