The invention discloses a manufacturing method of a nutritional skin-care skin-moisturizing powder-containing polyvinyl chloride (PVC) glove, which comprises the following steps: preparing materials, filtering, defoaming under vacuum, immersing, dropping, plasticizing, cooling, rolling edge, preparing powder, adhering powder and demoulding. The method is characterized in that: collagen and vitamin E are added during material preparation; and submicron wall-broken powder of pearl powder, dandelion, witch hazel, aloe, peach blossom and pear blossom is added into corn starch in a powder adhering process. The glove has the advantages of overcoming the drawbacks of the conventional PVC gloves, integrating sanitation, environment protection, safety, nutrition, skin care and skin moisturizing, offering comfortable wear and flexible use experience, avoiding any natural latex components and avoiding causing allergic reaction, along with good nutritional skin-care and skin-moisturizing functions.