The invention discloses a synthesis method of 5,6,7,8-tetrahydro-1,6-naphthyridine-2-amine. The synthesis method comprises the specific steps: (1) carrying out amino protection reaction on 2-halo-5,6,7,8-tetrahydro-1,6-naphthyridine to prepare 6-site-protected 2-halo-5,7,8-trihydro-1,6-naphthyridine; (2) carrying out palladium-catalyzed coupling reaction on the 6-site-protected 2-halo-5,7,8-trihydro-1,6-naphthyridine and carbamate under basic conditionsto prepare double-site-protected 5,7,8-trihydro-1,6-naphthyridine-2-amine; (3) carrying out deprotection reaction on the double-site-protected 5,7,8-trihydro-1,6-naphthyridine-2-amine to prepare 5,6,7,8-tetrahydro-1,6-naphthyridine-2-amine. In the whole technical process, only conventional reagents are used, the use of azides with high toxicity and environmental hazards is avoided, reaction conditions are mild and the method is safer and more environmentally friendly.