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49results about How to "Avoid rearrangement" patented technology

Method of preventing and/or treating oxidant injury in neurodegenerative and oxidative diseases

A method of treating and / or preventing oxidative damage, comprising administering an effective IsoK / NeuroK adduct formation suppressing amount of a phenolic amine compound and / or pyridoxamine or pyridoxamine analog, including embodiments where the phenolic compound is at least one of a pyridoxamine, salicylamine, tyrosine compound or an analog thereof.
Owner:VANDERBILT UNIV

Method for synthesizing azoxystrobin intermediate

The invention discloses a method for synthesizing an azoxystrobin intermediate. The synthesizing azoxystrobin intermediate has the structure shown as a formula (3). The method comprises the following steps of: under the alkaline condition, performing first contact reaction on 4,6-dihalogenopyrimidine and a compound shown as a formula (I) to obtain a product containing a compound with a structure shown as a formula (2); and under the alkaline condition, performing second contact reaction on the compound with the structure shown as the formula (2) or the product containing the compound with the structure shown as the formula (2) and 2-hydroxybenzonitrile in the presence of a catalyst to obtain the product containing the azoxystrobin intermediate with the structure shown as the formula (3), wherein the catalyst is 1,4-diazabicyclo[2.2.2]octane and / or 2-methyl-1,4-diazabicyclo[2.2.2]octane. The method for synthesizing the azoxystrobin intermediate has mild reaction conditions, is simple, has less Vilsmeier rearrangement reaction and ensures high reaction yield.
Owner:NUTRICHEM LAB CO LTD

Carboxy protection strategies for acidic c-terminal amino acids in chemical ligation of oligopeptides

The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotecte acidic C-terminal oligopeptide thioester. An important aspect of the present invention is providing side chain protected acidic C-terminal oligopeptide thioesters. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where aspartyl or glutamyl peptide fragments are used to assemble an oligopeptide, polypeptide or protein product
Owner:ASTRAZENECA PHARMA LP

Preparation method for fluocinolone acetonide midbody

The invention discloses a preparation method for a fluocinolone acetonide midbody, i.e., 21-acetate-9,11-epoxy-17-alpha-hydroxypregn-1,4-diene-3,20-diketone. A compound I, i.e., 11-alpha-hydroxy-ADD (androstadienedione), serves as a starting material; an elimination reaction, a cyano-substitution reaction, a siloxy protective reaction, an intramolecular nucleophilic substitution reaction, a bromo-epoxy reaction and a replacement reaction are carried out to obtain the fluocinolone acetonide midbody. The preparation method provided by the invention has the advantages that the starting material which is relatively cheap is used, the reactions in the steps are relatively easy to implement, and the yield is higher, so that the production is more economical and safe, and higher applicability for industrial production is achieved; through route design optimization, the preparation method avoids 9 (11)-double-bonded epoxidation with the existence of 21-acetate in the traditional technique, so as to avoid the 21-acetate hydrolysis, greatly improve the quality and yield of the fluocinolone acetonide midbody, and reduce the entire production cost.
Owner:江西赣亮医药原料有限公司

Transparent ceramic orthodontic bracket and preparation method thereof

ActiveCN111454067AReduce dispersionDifficult to discharge lowParaffin waxMicrocrystalline wax
The invention discloses a transparent ceramic orthodontic bracket and a preparation method thereof. The transparent ceramic orthodontic bracket comprise the following components in parts by weight: 80-90 parts of nano aluminum oxide and 10-20 parts of a binder, wherein the binder comprises the following five parts: a first part is a low-molecular component containing at least one of paraffin, microcrystalline wax, bee wax, EBS wax and PE wax, a second part is a catalytic component, namely homo-polymerized polyformaldehyde with a high melt index; a third part is a skeleton component containingat least one of polypropylene, polyethylene, an ethylene-vinyl acetate copolymer, POE and polystyrene; a fourth part is a plasticizer; and a fifth part is an organic silicon dispersing agent. The transparent ceramic bracket is high in density, few in air holes, high in light transmission and high in three-point bending strength.
Owner:浙江昶研新材料有限公司

Composite spinneret pack for preparing flap optical fiber

The invention relates to a compound spinning pack of preparing a valvular fiber, which comprises a distribution plate A, a distribution plate B and a spinneret, wherein the inner ring of the distribution plate A is equipped with an A component channel (1), the outer ring is equipped with a B component channel (2), the center of the distribution plate B is equipped with an A component moulding hole (3), and the outer ring is equipped with a B component channel (4). The center of the spinneret is equipped with a guide hole (5), the guide hole (5) is opposite to the A component moulding hole (3) which is arranged on the center of the distribution plate B, the end bottom of the guide hole is equipped with spinning microporouses, and the B component channel (4) is opposite to the B component channel (2). The fiber which is prepared by the invention comprises two components, a designed valvular fiber section shape is formed on the sections of the two components, the two components mutually contact and are not separated, thereby the performance of the fiber is better than a natural fiber.
Owner:DONGHUA UNIV

Method for preparing 7-hydroxydehydroabietic acid

The invention discloses a method for preparing 7-hydroxydehydroabietic acid, which comprises the following steps of: 1, adding 2 mass parts of rosin into 5 to 100 mass parts of organic carbon having 2 to 6 carbon atoms, stirring the mixture uniformly, and heating the mixture to fully dissolve the rosin; 2, adding the dissolved rosin solution into a fixed bed reactor filled with oxidant, keeping the temperature of the fixed bed reactor at 30 to 70 DEG C, and obtaining 7-hydroxydehydroabietic acid solution; and 3, filtering the 7-hydroxydehydroabietic acid solution, and performing distillation,re-crystallization and vacuum drying to obtain a pure 7-hydroxydehydroabietic acid product. The rosin is directly used as a raw material, so the steps are simplified, and the cost is saved; and the low-cost oxidant is used, the reaction is quick, and the yield of the 7-hydroxydehydroabietic acid reaches over 75 percent.
Owner:INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY

High-compactness modified alkaline phenolic resin self-hardening sand for pump valve castings and preparation method of high-compactness modified alkaline phenolic resin self-hardening sand

The invention discloses high-compactness modified alkaline phenolic resin self-hardening sand for pump valve castings. An adopted modified phenolic resin adhesive in the resin sand has the advantages that the viscosity is low, the bonding strength is high, the plasticity is good, the brittleness is low, the contents of free phenol and free formaldehyde are lower, the use amount is lower, the hardening speed is decreased, and the like, so that the use and reuse performance of the molding sand can be effectively improved; through the addition of polylactic acid fiber and porous polypropylene fiber added in the sand, the thermoplasticity time during the casting pouring process is longer, the stress generated after sand heating is relieved, the retention time of a sand mold is prolonged, the castings are prevented from cracking, the air permeability is improved, the rearrangement and densification of the sand are facilitated in the fiber low-temperature fusion introduction instant liquid state, and the precision of pump valve castings is improved.
Owner:合肥李诺新材料贸易有限公司

Binder as well as preparation method and application thereof

The invention discloses an adhesive as well as a preparation method and application thereof. The adhesive is prepared from, by weight, 3-10 parts of low-molecular-weight wax components, 20-50 parts of1 # polyacrylic resin, 0-30 parts of 2 # polyacrylic resin, 5-15 parts of high-temperature decomposition resin, 0.5-2 parts of plasticizer and 0.1-3 parts of dispersing agent. The preparation methodof the binder comprises the following steps of: (1) weighing the components; (2) performing stirring at high temperature; and (3) performing crushing and granulating. The binder is used for preparingaluminum oxide or zirconium oxide thermal degreased injection-molded ceramic. An injected ceramic green body applying the binder can be directly subjected to whole-course thermal degreasing, is smoothin feeding surface, is high in strength, is good in flowability and easy to automatically produce; the prepared injection-molded ceramic product has few pores, high density, high hardness and strength and excellent comprehensive performance.
Owner:浙江昶研新材料有限公司

CT reconstruction method based on fractal and compression sensing

The invention provides a CT reconstruction method based on fractal and compression sensing. The method includes the steps that (1) CT projection data b, a corresponding projection angle theta and initialization parameters beta, lambda and lambda n are known, and a CT image u is equal to zero; (2) a corresponding projection matrix A is calculated according to the projection angle theta; (3) a CT image uART is calculated by means of a formula (5); (4) fractal encoding processing is carried out on uART, so that fai (u) is obtained, and alpha is obtained by means of a formula (12); (5) decoding processing is carried out on the fai (u), so that fai T(u) is obtained; (6) fai T(u), fai (u), fai T(u) alpha, ATA and ATb are solved; (7) a formula (15) is solved in a conjugate gradient method, and accordingly a CT image is obtained; (8) whether a condition of finishing iteration is met is detected, if the answer is positive, a step (9) is carried out and otherwise the step (3) is carried out; (9) operations are finished, and the CT image is output. According to the method, fractal serves as sparse transform so that a more sparse coefficient representation can be obtained, an alternating and continuity algorithm is used for obtaining solutions and the high-quality CT image is constructed on the condition that a little of projection exists.
Owner:CHONGQING UNIV

Method for preparing nucleic acid probe-coated porous solid support strip

ActiveCN102559877AAvoid the inconvenience of controlling the optimal amount of UV exposureIncrease production capacityMicrobiological testing/measurementMicroorganism based processesPorous solidsNucleic Acid Probes
Disclosed is a method for preparing a nucleic acid probe-coated porous solid support strip. The method includes linking a nucleic acid probe to a carrier to prepare a conjugate and immobilizing the conjugate on a porous solid support by vacuum transfer.
Owner:LG CHEM LTD

Winding drum with cable guide grooves

The invention discloses a winding drum with cable guide grooves. The winding drum mainly comprises an H-shaped shaft and threaded tracks. The threaded tracks which are neatly arrayed are arranged on the surface of the H-shaped shaft and are of groove-shaped structures, the widths of grooves are matched with the diameters of cables, and the depths of the grooves are matched with the radiuses of the cables. The winding drum with the cable guide grooves has the advantages that the threaded tracks can be in modes for assisting in preventing rearrangement and mistaken arrangement of the cables, and accordingly conditions such as cable compression, disorder and squeezing can be prevented by the threaded winding drum under double protection effects of inspection mechanisms and the threaded tracks; the winding drum is simple in structure, reasonable in design and suitable to be widely applied to industries with requirements on winding displacement equipment.
Owner:江苏三科海洋装备有限公司

Semiconductor structure and fabricating method thereof

A semiconductor structure and a method of fabricating the semiconductor structure are disclosed herein. The semiconductor structure includes a substrate, a strain-inducing layer and an epitaxy structure. The strain-inducing layer is disposed on the substrate, and the epitaxy structure is embedded in the strain-inducing layer and not in contact with the substrate.
Owner:TAIWAN SEMICON MFG CO LTD

Preparation method of alkyl aromatic compound based on alkenyl ether Friedel-Crafts reaction

The invention discloses a preparation method of an alkyl aromatic compound based on an alkenyl ether Friedel-Crafts reaction, and belongs to the technical field of pharmaceutical and chemical intermediates and related chemistry. According to the method, alkenyl ether and an aromatic compound are used as raw materials, and green and efficient synthesis of the alkyl-substituted aromatic compound isrealized under the catalytic action of Lewis acid or protonic acid. The method has the advantages of high selectivity, mild reaction conditions, good functional group compatibility, the wide substraterange, environmental friendliness and the like. The alkyl-substituted aromatic compound is an important organic synthesis intermediate and has very wide application in the fields of organic synthesisand pharmacy, so that the alkyl-substituted aromatic compound has relatively high application value and social and economic benefits.
Owner:LIUPANSHUI NORMAL UNIV

Method for improving strength of Fe-Mn-Al-C series low-density steel

The invention relates to a method for improving the strength of Fe-Mn-Al-C series low-density steel, and belongs to the technical field of metal materials. The method comprises the steps that firstly, a Fe-Mn-Al-C series steel part is subjected to solution treatment and then subjected to rolling deformation treatment, wherein the rolling reduction ranges from 20% to 70%, and the finish rolling temperature ranges from 500 DEG C to 850 DEG C; and finally, heat preservation is conducted for 0.5-3 h at the temperature of 350-600 DEG C, aging treatment is conducted, and after aging treatment is finished, the steel is cooled to room temperature in air to obtain the low-density high-strength Fe-Mn-Al-C series steel. The yield strength of the Fe-Mn-Al-C series low-density high-strength steel obtained through the method reaches 1370-1900 MPa, the ultrahigh strength level is achieved, and meanwhile the ductility is kept to be 8% or above.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY

Method and system for processing node data based on html

The invention discloses a node data processing method and a system based on Html. The method includes: obtaining web resources based on Html; generating nodes including a DOM object n by parsing web resources withJavascript language, wherein the web page resources include static resources and dynamic resources, and the static resources include Javascript script files; merging Javascript script files; rendering the DOM object and displaying the Web page. The technical scheme of the invention can at least perform real-time data display for a node diagram with a large amount of data.
Owner:DAWNING INFORMATION IND BEIJING +1

VBA-based hospital outpatient pharmacy scheduling method

The invention discloses a VBA-based hospital outpatient pharmacy scheduling method, which adopts a greedy algorithm and a backtracking algorithm to obtain an approximate solution of scheduling, accurately realizes full-class and full-period scheduling of all staff of hospital outpatient pharmacy, reduces repeated work of simple work, reduces and checks low-level errors such as missed scheduling, multiple scheduling and wrong scheduling, improves the scheduling efficiency, and enhances the accuracy; meanwhile, a scheduling table checking function is provided, a full scheduling table is checked, and missed scheduling, excessive scheduling and wrong scheduling caused by manual adjustment of the scheduling table are avoided; the preset constraint conditions conform to the hospital outpatient pharmacy scheduling rule, the method can be popularized to the pharmacy in a similar scheduling mode, and the constraint conditions for the work shift and the rest shift can promote the enthusiasm of the pharmacy scheduling personnel in the actual work, relieve the work fatigue and ensure sufficient rest.
Owner:河源市深河人民医院(暨南大学附属第五医院)

Mirror for the EUV wavelength range, projection objective for microlithography comprising such a mirror, and projection exposure apparatus for microlithography comprising such a projection objective

ActiveUS20100265480A1High theoretical reflectivity valueIncrease valueMirrorsOptical filtersRutheniumWavelength range
A mirror for the EUV wavelength range (1) having a layer arrangement (P) applied on a substrate (S), the layer arrangement having a periodic sequence of individual layers, where the periodic sequence has at least two individual layers—forming a period—composed respectively of silicon (Si) and ruthenium (Ru). Also disclosed are a projection objective for microlithography (2) including such a mirror, and a projection exposure apparatus for microlithography having such a projection objective (2).
Owner:CARL ZEISS SMT GMBH

Manufacture of synthetic quartz glass substrate

A rough surface of a starting synthetic quartz glass substrate is polished to a mirror finish, using a polishing slurry containing tetragonal or cubic zirconia.
Owner:SHIN ETSU CHEM IND CO LTD

Method and system for solving multi-thread problem caused by CPU optimization

The invention discloses a method for solving a multi-thread problem caused by CPU optimization. The method relates to the field of internet application development, and comprises the following steps:setting a memory gate barrier in a program code, and then optimizing a CPU (Central Processing Unit), the memory gate barrier being used for sequentially executing all program codes before the memorygate barrier during CPU optimization to prevent code rearrangement. According to the method for solving the multi-thread problem caused by CPU optimization, the problem of result abnormity caused by multiple threads caused by CPU optimization can be effectively solved, and the method is safer and more reliable.
Owner:WUHAN DOUYU NETWORK TECH CO LTD

Transmitter terminal and receiver terminal

This invention relates to transmitter and receiver terminals that transmit and receive real-time streaming data via a network. This invention achieves reduction of ultimate transmission delay time by avoiding the occurrences of reorders themselves. In the transmitter terminal (1), a padding request accepting unit (103) receives a padding request packet transmitted by the receiver terminal (2). Based on an instruction from the padding request accepting unit (103), a packet padding unit (102) pads a packet, which has been generated by a data generating unit (101), such that the packet length of the packet is equal to or greater than a particular length. The packet padding unit (102) then transmits the packet as padded to a network (10). In the receiver terminal, a reorder condition analyzing unit (201) analyzes the reorder-occurrence condition of the packet received from the network. Based on an analysis result received from the reorder condition analyzing unit (201), a padding requesting unit (204) generates and transmits a padding request packet to the transmitter terminal. A data reproducing unit (203) reproduces the packet received by the reorder condition analyzing unit (201).
Owner:PANASONIC CORP

Synthesis method of 6,6-dialkyl piperidine-2-carboxylic acid compound

The embodiment of the invention provides a brand-new synthesis method of the 6,6-dialkyl piperidine-2-carboxylic acid compound; a compound I, trifluoroacetic acid, sodium hydroxide and the like are used as raw materials, and the target product 6,6-dialkyl piperidine-2-carboxylic acid is obtained through two-step reaction. The synthesis method provided by the embodiment of the invention has the advantages of simple operation, mild reaction conditions, high yield, environmental friendliness, low production cost and the like, and is suitable for industrial large-scale production.
Owner:上海毕得医药科技股份有限公司

Method for preparing nucleotide probe-coated porous solid support strips

Disclosed is a method for preparing a nucleic acid probe-coated porous solid support strip. The method includes linking a nucleic acid probe to a carrier to prepare a conjugate and immobilizing the conjugate on a porous solid support by vacuum transfer.
Owner:因维特洛斯有限公司

Method for producing n-propylbenzene by using benzene and isopropanol

The invention relates to a method for producing n-propylbenzene by using benzene and isopropanol. The method comprises the step of contacting benzene and isopropanol with a catalyst under the effective reaction condition to obtain the n-propylbenzene, and is characterized in that the effective reaction condition comprises that the temperature is at least more than 200 DEG C. The method can be applied to industrial production of the n-propylbenzene.
Owner:CHINA PETROLEUM & CHEM CORP +1

The method for producing n-propylbenzene from benzene and isopropanol

The invention relates to a method for producing n-propylbenzene from benzene and isopropanol, comprising the step of contacting benzene and isopropanol with a catalyst under effective reaction conditions to obtain n-propylbenzene; it is characterized in that said effective reaction conditions include a temperature of at least Greater than 200°C. The method can be used in the industrial production of n-propylbenzene.
Owner:CHINA PETROLEUM & CHEM CORP +1
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