The invention discloses a weeding device for a river course, and relates to the technical field of clearing of the river course. The weeding device comprises a handhold part, a connecting device, a fixing device and a pesticides cartridge, wherein the connecting device is arranged on the handhold part; the fixing device is arranged on the connecting device; the pesticides cartridge is arranged onthe fixing device; the handhold part is composed of a holding rod, an anti-skid casing and a spring clamping buckle; the connecting device is composed of a sleeve, a clamping block, a bottom plate anda fixed block; the fixing device is composed of a connecting pipe, a fixed ring, a support rod, a limiting rod and a vertebral body; the pesticides cartridge is composed of a cartridge body, an upperplate and a lower plate; and the upper plate and the lower plate are arranged on the cartridge body. The weeding device for the river course disclosed by the invention is high in practicability, andis very convenient to use; moreover, water weeds in the river course and ponds can be essentially killed, and re-growth of the water weeds can be prevented; and moreover, the device is convenient to detach, easy to recycle, and has less influence on water quality of positioned water domains.