The invention provides a whole-house air epidemic prevention energy-saving system. The whole-house air epidemic prevention energy-saving system comprises a shell, wherein an indoor air supply chamber,an air inlet disinfection and filtration assembly, a first power chamber, an air inlet flow dividing system and an air inlet pipe are sequentially arranged on the outer side of the shell from left toright; and an indoor air return pipe, an indoor air return chamber, an air return disinfection assembly, a second power chamber, an air exhaust flow dividing system and an air exhaust pipe are sequentially arranged on the inner side of the shell from left to right. The whole-house air epidemic prevention energy-saving system provided by the invention has the advantages that fresh air can be introduced to keep comfort, viruses and bacteria are diluted by increasing the fresh air exchange amount, the air flow organization form of an indoor room is changed to prevent virus expansion, the air return disinfection assembly is arranged to sterilize and disinfect breathed air, the air inlet disinfection and filtration assembly is arranged to sterilize and filter outdoor introduced fresh air, therequirement for epidemic prevention is met, and the situations of cross infection, secondary infection and the like of air viruses are avoided. In addition, the air treatment system has higher energyconsumption efficiency.