80results about How to "Meet the requirements of industrialized mass production" patented technology

The present invention discloses one kind of conductive plastic and its processing method and apparatus. The conductive plastic includes conductive fiber 0.1-45 vol%, thermoplastic plastic 55-99 vol% and machining assistant 0-3 vol%. The conductive fiber is arranged in 3D netted form homogeneously with multiple joining points, and the conductive plastic has high conductivity, high antistatic and electromagnetic shielding effect, and low surface resistance and volumetric resistivity, and may be injected, extruded and molded like common plastic.

The invention provides a method of preparing calcium gluconate by a composite immobilized enzyme. Improvement is made on the basis of present methods which produce the calcium gluconate by a free composite enzyme method. Glucose oxidase and catalase are added into a mixed solution of sodium alginate and silica gel, and then are added dropwise into a calcium carbonate solution to be immobilized and moulded. The glucose oxidase and the catalase are immobilized to achieve enzyme liquid separation, thus improving the repeating utilization ratio of the glucose oxidase and the catalase and reducing the using cost of the enzyme. A calcium gluconate product produced by the method provided by the invention is high in purity, and conforms to requirements of the country about energy conservation and environment protection of enterprises at present.

The invention provides a novel intermediate and a novel route for synthesizing epirubicin hydrochloride by utilizing the intermediate. The route is simple, cheap and efficient, achieves better energy conservation and emission reduction, and avoids the problems that an intermediate generated by the existing epirubicin hydrochloride synthesis route is water-instable and easy to decompose and a yield of the whole route is low. The route uses a low-cost and easy-to-obtain reagent and adopts a removable selective protection means; generated impurities are few; the purity is high; a yield is high.

The invention provides a novel intermediate and a novel route for synthesizing epirubicin hydrochloride by utilizing the intermediate. The route is simple, cheap and efficient, achieves better energy conservation and emission reduction, and avoids the problems that an intermediate generated by the existing epirubicin hydrochloride synthesis route is water-instable and easy to decompose and a yield of the whole route is low. The route uses a low-cost and easy-to-obtain reagent and adopts a removable selective protection means; generated impurities are few; the purity is high; a yield is high.

The invention discloses a solid preparation of atorvastatin calcium liposome. The preparation is prepared from the atorvastatin calcium liposome and other pharmaceutically common auxiliary materials, wherein the atorvastatin liposome is prepared from the following components in parts by weight: 1 part of atorvastatin calcium, 2-5 parts of phospholipid and 0.8-3 parts of additive. The atorvastatin solid preparation prepared from the liposome has the advantages that the dissolution rate is increased, the stability and bioavailability are greatly improved, the product quality of the preparation is improved and the toxic and side effect is reduced.

The invention discloses a method for compounding a trans-hydroxyl active metabolite of loxoprofen. The method comprises the following steps: taking 2-[p(bromomethyl)phenyl]propionic acid as a raw material and carrying out resolution and methyl esterification, thus obtaining an intermediate, namely, a compound as shown in a formula 3; preparing a chiral assistant, namely, a compound as shown in a formula 7, by starting from L-phenylalaninol; firstly forming Schiff base as shown in a formula 9 by cyclopentanone and the chiral assistant, namely, the compound as shown in the formula 7, and then condensing the Schiff base as shown in the formula 9 and the intermediate, namely, the compound as shown in the formula 3, into an intermediate, namely, a compound as shown in a formula 11; carrying out acidic hydrolysis on the intermediate, namely, the compound as shown in the formula 11, and perfroming stereoselective reduction on cyclopentanone carbonyl groups, thus obtaining the trans-hydroxyl active metabolite, namely, a compound as shown in a formula TM. In a compounding path, raw materials can be easily obtained, the operation is convenient, environmental friendliness is realized, a separation means of column chromatography is prevented from being used, and the technical requirements of industrial large-scale production can be completely met.

The invention discloses a round bar stock arranging device, which comprises a material feeding platform (1) and a conveying unit. The round bar stock arranging device is characterized in that the conveying unit comprises a planar conveying unit (3) and a V-shaped conveying unit (4), both of which are mutually engaged and form a right angle. The bar stock arranging device of the structure, disclosed by the invention, can transversely and vertically convey round bar stocks pre-arranged by the material feeding platform through the conveying unit and then completely arranges the bar stocks, thus the bar stocks are arranged orderly and are convenient for the operation of a subsequent working process.

The invention provides a novel intermediate and a novel route for synthesizing epirubicin hydrochloride by utilizing the intermediate. The route is simple, cheap and efficient, achieves better energy conservation and emission reduction, and avoids the problems that an intermediate generated by the existing epirubicin hydrochloride synthesis route is water-instable and easy to decompose and a yield of the whole route is low. The route uses a low-cost and easy-to-obtain reagent and adopts a removable selective protection means; generated impurities are few; the purity is high; a yield is high.

The invention provides a novel intermediate and a new route for synthesizing epirubicin hydrochloride by using the intermediate. The route is simple, cheap and efficient, and meanwhile, the problems that the intermediate generated by an existing epirubicin hydrochloride synthesis route is instable in water and easy to decompose and the whole route is low in yield are solved. In order to better achieve energy conservation and emission reduction, a cheap and available reagent is utilized by the route; and meanwhile, removable selective protection means are adopted, so that the generated impurities are few, the purity is high and the yield is high.

The invention relates to a citicoline sodium liposome solid preparation which is mainly prepared from citicoline sodium, phospholipid, an additive and other pharmaceutic adjuvants, wherein the citicoline sodium accounts for 1 part by weight, the phospholipids accounts for 2-12 parts by weight, and the additive accounts for 0.5-8 parts by weight. The liposome solid preparation prepared by the invention has the advantages that the stability of the active ingredient citicoline sodium is greatly improved, the valid period of product is prolonged, and phospholipid absorption is cooperated with the curative activity of the citicoline sodium, thus the bioavailability is improved, the product quality of the preparation is improved, and toxic and side effects are reduced.

The invention discloses a water-based Low VOC high-metal texture two-component polyurethane low-temperature curing coating and a preparation method thereof. The coating comprises a main agent A and a curing agent B, the main agent A comprises the following components: 25 to 40 parts of waterborne polyurethane (PU) and acrylic dispersion resin, 0.1 to 0.3 part of a pH regulator, 2 to 5 parts of a waterborne coalescing agent, 0.3 to 1 part of a waterborne wetting agent, 0.2 to 1.0 part of a waterborne flatting agent, 20 to 40 parts of a self-made waterborne silver bar additive, 4 to 12 parts of self-made silver soaking water, 4 to 6 parts of waterborne aluminum silver paste, 0 to 6 parts of pearl powder, 0 to 10 parts of waterborne color paste, 0 to 5 parts of a functional additive, 1 to 5 parts of a thickening thixotropic agent, and 6.5 to 15 parts of deionized water; and the curing agent B comprises the following components in parts by weight: 70-80 parts of a water-based isocyanate curing agent and 20-30 parts of a curing agent diluent; and the method is characterized by mixing the main agent A and the curing agent B into the mixed structure and uniformly stirring. The invention provides the preparation method of a water-based Low VOC high-metal texture two-component polyurethane low-temperature curing coating. The good balance between the high-metal texture appearance and excellent physical and chemical resistance of a two-component polyurethane coating film under the water-based Low VOC condition is realized.

The invention discloses an industrial method for continuously extracting high-content marigold flavone, wherein the method comprises the following steps: 1) granulating a marigold flower raw material according to a granulator circular mold compression ratio of 1:(1.2-2.2); 2) extracting the marigold flower particles by using 70%-100% acetone as an extracting agent, and filtering to obtain an extracting solution; and 3) down-regulating the volume fraction of acetone to 0-30%, filtering to obtain a filter cake, and drying the filter cake to obtain a marigold flavone product. The method is simple, high in continuity and operability, high in productivity, low in energy consumption and suitable for industrial production.

The invention provides a formula of an acrylic lacquer. The acrylic lacquer comprises the following components in percentage by mass: 55-65% of 801 resin, 25-35% of 582-2 resin, 3-5% of butanol, 2-3% of xylene, 2-4% of cyclohexanone, 0.20-0.40% of 358 auxiliaries and 0.03-0.07% of 331 auxiliaries. According to the invention, acrylic resin is used as the raw material for preparing the lacquer; and the prepared acrylic lacquer can be dried at normal temperature and is favorable in weather, light, heat and mildew resistance and adhesive force, suitable for being sprayed on the surface of an aluminum alloy subjected to anodic oxidation treatment and being used as a sealing agent in wood coating, firm and bright in paint film, capable of being insulated, rapid in drying, better in adhesive force, simple in production process, lower in raw material cost and capable of meeting the requirement of large-scale industrial production.