The present invention relates to the field of building, bridge and harbor engineering, and provides a pre-stress FRP bush-FRP rib sea sand seawater expansion concrete combination column, which comprises an external FRP bush and internal FRP rib sea sand seawater expansion concrete, wherein the FRP bush wraps the sea sand seawater expansion concrete, self-stress is generated in the FRP bush and the concrete through the expansion of the concrete and the restriction of the FRP, uniformly distributed FRP longitudinal ribs are arranged on the periphery close to the sea sand seawater expansion concrete combination column, and penetrate through the sea sand seawater expansion concrete from top to bottom, and FRP spiral stirrups are bound around the FRP longitudinal ribs from the outer side along a top-to-bottom direction of the combination column according to the same interval and the same spiral angle. According to the present invention, the pre-tensile stress is generated in the FRP bush through the micro-expansion of the expanded concrete so as to effectively improve the axial limit bearing force of the combination column; and the river sand is replaced by the sea sand, the fresh water is replaced by the seawater, and the steel bar is replaced by the FRP rib, such that the performance of the combination column is improved, the limitation of the application of the sea sand seawater in the practical engineering is broken through, and the positive effect is provided in the protection of the ecological environment.