The invention discloses a nickel oxide ore acid leaching solution two-step iron removal method. The method comprises the following steps: adding garnierite ore pulp into a nickel oxide ore acid leaching solution, stirring and reacting until the dissolution is completed and the pH value of the solution is more than or equal to 1.6, performing liquid-solid separation, raising the temperature of obtained liquid to 130-170 DEG C, stirring and reacting for 1-3 hours, performing liquid-solid separation, and drying a solid to obtain a hematite product; adding the garnierite ore pulp into the collected liquid for the second time, stirring and reacting until the dissolution is completed and the pH value of the solution is about 2, performing liquid-solid separation, and adding magnesium oxide and an oxidizing agent into the obtained liquid, or only adding the oxidizing agent; stirring and reacting for 0.5-4 hours, performing liquid-solid separation, and drying the solid to obtain a goethite product. By adopting the method disclosed by the invention, complete iron removal can be achieved under a relatively mild condition; hematite and goethite which can be directly sold can be obtained; meanwhile, residual acid in the acid leaching solution and acid released in the iron deposition process are recycled; loss of nickel, cobalt, aluminum and magnesium in the leaching solution can not be generated.