11 results about "Injuries diseases" patented technology

The invention provides a benzofuranone compound as well as a pharmaceutical composition and application thereof, and relates to the technical field of medicines. The benzofuranone compound is a compound as shown in a formula I, a stereoisomer thereof, a tautomer thereof, a crystalline hydrate thereof, a solvate thereof, a prodrug thereof or a pharmaceutically acceptable salt thereof. The benzofuranone compound and the pharmaceutical composition and the pharmaceutical preparation prepared from the benzofuranone compound can prevent or treat organ injury diseases, and have good treatment effects in kidney injury, liver injury, lung injury, brain injury and heart injury.

This application relates to the field of gene transduction technology, specifically disclosing a method and application for modifying mesenchymal stem cells (MSCs) targeting myocardial injury. The method includes: S1, obtaining umbilical cord-derived MSCs; S2, performing surface biomimetic modification on the MSCs; S3, gene editing on the MSCs; and S4, co-incubating the engineered MSCs with enzyme-responsive liposomes loaded with nitric oxide donors. The liposomes are embedded in a gelatin coating on the cell membrane surface through hydrophobic interactions, forming a targeted therapeutic system. This method for modifying MSCs targeting myocardial injury can be used for regenerative therapy and repair of myocardial injury diseases such as myocardial infarction and ischemic heart disease. It comprehensively improves the survival and stress tolerance of cells after implantation and enhances the targeting precision to the damaged site, thereby achieving the advantages of efficient, precise, and highly adaptable myocardial repair.

The present application relates to the technical field of medicine, in particular to a kind of drug composition for improving acute alcoholic gastric mucosal injury and application.The present application discloses the new medical use of ganoherbae decoction for the first time, and the composition can increase the activity of key enzyme in the stomach and liver tissue of acute alcoholic gastric mucosal injury mice, reduce the content of pro-inflammatory factor TNF-α in gastric tissue, increase the production of anti-inflammatory factor IL-10 in gastric tissue, reduce the inflammatory damage of ethanol to gastric mucosa, increase the level of protective factor EGF, SS and PGE-2 in serum, enhance the defense mechanism of gastric mucosa, and improve the repair ability of gastric mucosa.The discovery will have a significant impact on the research and treatment of acute alcoholic gastric mucosal injury disease, and has clinical practical value.

The invention discloses an apostichopus japonicus extract antioxidant peptide as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The amino acid sequence of the apostichopus japonicus essence antioxidant peptide is shown as SEQ ID NO. 1. The apostichopus japonicus essence antioxidant peptide has the advantages that the apostichopus japonicus essence antioxidant peptide is prepared; the antioxidant peptide with the amino acid sequence of LPPF is screened from the apostichopus japonicus essence, and the peptide is proved to have excellent antioxidant activity and high safety, and has a better application prospect in treatment of oxidative stress injury diseases.

The present invention provides use of a neural cell population for treating a neuronal injury disease, a neurodegenerative disease, a neurodevelopmental disease, or a pathology associated with the death and / or dysfunction of forebrain neurons, wherein the neural cell population comprises forebrain neural progenitor cells (FNPCs) with specific developmental characteristics. Preferably, the forebrain neural progenitor cells with specific developmental characteristics highly express markers including FOXG1, PAX6, and NESTIN. Preferably, the neural cell population is obtained by culturing human pluripotent stem cells (hPSCs).

The invention discloses a gene composition, a mitochondrial-containing vesicle based on fat cells and application of the mitochondrial-containing vesicle. The gene composition containing a CD38 gene, an shLDHA gene and an ANXA1 gene is delivered or transferred into the fat cells; after the adipocyte expresses the gene, the adipocyte continuously secretes vesicles which express ANXA1 on the surface and internally contain functional mitochondria. The vesicle constructed by the invention is used as a natural carrier, functional mitochondria is accurately delivered to a myocardial injury area through blood circulation, myocardial cell energy metabolism is repaired, vascular endothelial cell functions and angiogenesis are promoted, cell apoptosis and fibrosis are inhibited, and finally heart functions are improved. According to the method, complex processes of in-vitro separation, purification and vesicle reinjection are avoided, a biological factory with a continuous effect is constructed by utilizing endogenous fat cells, the method has the outstanding advantages of simplicity and convenience in operation, lasting effect, strong targeting property, low immunogenicity and the like, and a brand new treatment strategy is provided for myocardial injury diseases.

The application discloses an antioxidant peptide from Apostichopus japonicus and a preparation method and application thereof, and relates to the technical field of biological medicines. The antioxidant peptide from Apostichopus japonicus has an amino acid sequence as shown in SEQ ID NO. 1. The antioxidant peptide with the amino acid sequence of LPPF is screened from the Apostichopus japonicus, and the peptide is verified to have excellent antioxidant activity and high safety, and has a good application prospect in the treatment of oxidative stress injury diseases.

The invention discloses a method and system for measuring and calculating the burden of a multi-dimensional interactive injury disease, and relates to the field of public health and preventive medicines.The method comprises the steps that mapping processing is conducted on multi-dimensional injury associated data based on an attention mechanism, the attention weight is obtained through calculation, and a dynamic injury chain conduction chain is established; configuring a conduction coefficient for a dynamic damage chain conduction chain; based on a dynamic damage chain and a conduction chain, introducing attention weights of different dimensions to obtain an interaction effect matrix of each stage; calculating staged DALY values based on the interaction effect matrix of each stage, summarizing the staged DALY values to obtain a total DALY value, constructing a cross-scale Bayesian network, and reasoning the total DALY value based on the cross-scale Bayesian network to obtain posterior distribution of the total DALY value; and taking the mean value of the posteriori distribution of the total DALY value as a final measurement and calculation value, and outputting the contribution ratio of 95% confidence interval to each scale. According to the scheme, multi-dimensional collaborative toughness correction and cross-scale fusion are adopted to realize full-chain accurate measurement and calculation.

The application relates to a compound for improving vascular endothelial cell function, a preparation method and application thereof. The compound is prepared by taking tyrosol, dopamine, substituted cinnamic acid or 5-carboxyl pentyl-triphenyl phosphonium bromide as a starting material, and then performing amidation or esterification reaction with adamantylamine and adamantane acid. The compound has a significant inhibitory effect on the inflammation reaction of endothelial cells induced by palmitate (PA) as an anti-inflammatory molecule, can be used for preparing drugs for hyperlipidemia and related cardiovascular diseases, treating vascular endothelial injury diseases, treating hyperlipidemia, atherosclerosis and related cardiovascular diseases, and has the potential of being developed into innovative drugs for treating hyperlipidemia, atherosclerosis and related cardiovascular diseases with high efficiency and low toxicity.

The application discloses application of a GPR120 agonist in preventing or treating intestinal-liver immunological injury induced by poultry acetochlor poisoning. According to the intestinal-liver toxicity of chicken acetochlor, the normal expression of G protein-coupled receptor 120 is mainly changed. Subsequently, programmed cell death occurs in the intestinal tract and the liver, and a large amount of inflammatory factor release is caused; the intestinal-liver axis immunological injury is improved by activating the G protein-coupled receptor 120 in vivo and in vitro, so as to rescue the chicken acetochlor poisoning reaction. The application provides a prevention and treatment basis for poultry acetochlor poisoning immunological injury diseases, provides medical data for developing poultry immunological activity drugs or supplements, and also provides more technical means for developing and utilizing environment-friendly, efficient, targeted and slow-release new veterinary drug preparations.

The invention provides the application of SCD1 in preparing the medicine for treating the nerve myelin sheath injury diseases, the application reveals that SCD1 serves as a brand-new target spot for treating the sciatic nerve myelin sheath injury diseases for the first time, the target spot blank of existing targeted lipid metabolism regulation myelin sheath regeneration medicine is filled, and all-around repairing can be achieved from the molecule, form and function level; on one hand, the SCD1 can up-regulate expression of genes such as PMP22 and MPZ and promote myelin sheath synthesis from the source, and on the other hand, the SCD1 can also increase the myelin sheath thickness, reduce the number of non-marrow nerves and improve the structural integrity and stability of regenerated myelin sheaths; meanwhile, the SCD1 can prolong the dwell time of the rotating rod, accelerate the nerve conduction speed and improve dyskinesia and nerve conduction abnormity after sciatic nerve injury; besides, regulation of endogenous lipid metabolism is taken as a core mechanism, an intervention mode is safe and controllable, an experimental system is mature and repeatable, and an efficient, stable and safe new strategy is provided for clinical treatment of sciatic nerve myelin sheath injury.