The invention provides a selenium-enriched purslane compound fresh vegetable nutrition juice and a preparation method, wherein the selenium-enriched purslane compound fresh vegetable nutrition juice comprises raw materials with parts by weight: selenium-enriched purslane 30-40 parts, celeries 5-10 parts, cucumbers 5-10 parts, carrots 10-15 parts, radishes 5-10 parts, fresh corns 5-10 parts, bitter gourds 5-10 parts, Chinese cabbages 5-10 parts, chaenomeles speciosa 5-10 parts, lemon juices 0.5-1 part and water 100-120 parts. The method for preparing the selenium-enriched purslane compound fresh vegetable nutrition juice comprises steps: all raw materials beside lemon juice and the water are removed, are smashed in a frozen state orderly by de-seeding and mixing, are added with water to beat and are filtered to remove slag, and further use the lemon juices to mix juice, thereby obtaining the selenium-enriched purslane compound fresh vegetable nutrition juice. The selenium-enriched purslane compound fresh vegetable nutrition juice has the advantages of nutritive equilibrium, rich nutritional ingredients and high selenium content and the like, and has the effects to improve immunity, prevent cancer and chronic diseases and prolong life and the like, and the method for preparing the selenium-enriched purslane compound fresh vegetable nutrition juice is high in juice yield, high in dissolution rate of nutrient substances and less in heat loss.