1results about How to "Mild reaction" patented technology

The application relates to a synthesis method of a Bose factor, which comprises the following process steps: step (1): mixing xylose, acetylacetone and an alkaline substance in a solvent and heating to react to obtain a first intermediate product crude product; step (2): mixing potassium phosphate buffer, the first intermediate product crude product obtained in step (1), a KRED2935 crude enzyme solution, glucose dehydrogenase, glucose and beta-nicotinamide adenine dinucleotide phosphate monosodium salt, and converting at 25-35 DEG C for 1-2 h; after the conversion is completed, adding ethyl acetate to terminate the reaction, extracting, combining the organic phases, adding anhydrous sodium sulfate to dry, and then removing the solvent under reduced pressure through rotary evaporation to obtain the Bose factor. The application can obtain the Bose factor with high stereoselectivity, the conversion rate is high, the obtained product is easy to separate, and the problems of low stereoselectivity and difficult process amplification production in the prior art are overcome.