The invention discloses continuous cropping-preventing potato special-purpose fertilizer prepared from potato seedlings. The continuous cropping-preventing potato special-purpose fertilizer is prepared from 100kg of dry potato seedling powder, 10kg of urea, 10kg of diammonium phosphate, 10g of potassium sulfate, 4kg of sea mud, 2kg of glutinous rice bran, 2kg of calcium superphosphate, 0.5kg of sodium selenite, 1kg of seaweed meal, 0.5kg of iron chelate, 1.2kg of bamboo powder, 1.5kg of rapeseed cake, 0.5kg of shell powder, 1.5kg of bagasse and 0.6kg of sterilization powder. In preparation, the above ingredients are uniformly mixed through a mixer and the mixture is subjected to granulation. The continuous cropping-preventing potato special-purpose fertilizer can provide enough nutrients for potatoes, stimulate and promote potato growth through microbe decomposer and metabolite absorption and utilization of potato roots, improve a potato yield, and realize uniform growth, smooth appearance, big and beautiful fruits, drought and flood resistance and cold and heat resistance.