A manufacturing method of a ramie blend fiber towel relates to the technical field of the ramie weaving technology. The manufacturing method comprises the steps of: 1, combining two ramie blended yarns by using a doubling winder and then winding to form a bobbin; 2, feeding the combined bobbin into a doubling and twisting machine for twisting; 3, winding the twisted yarns into bobbin yarns and weaving to form grey cloth; 4, immerging and steaming the grey cloth through a solution, removing a sizing agent and cotton yarn impurities; deoxidizing, dyeing, enzyme-washing, softening, drying and sewing to form a towel. The manufacturing method of the ramie blend fiber towel avoids the problems of exposure of hairs due to too high elasticity of the ramie fibers, serious itchy feeling in use and the like, has few hairs, high strength, good abrasive resistance and fast moisture absorption and moisture diffusion, is anti-microbial and mildew-proof, anti-static, anti-UV, flexible, comfortable, and not easy to generate peculiar smell in the rainy weather.