The invention is comprehensive heath-care wine. Based on the mixture of fermented grape juice distilled wine and millet vinegar, Chinese herbal medicines including hawthorn, burdock root, cassia seed, cynomorium songaricum, Chinese angelica, eucommia bark, medicinal cyathula root, codonopsis pilosula, dried longan pulp, liquoric root, astragalus, cinnamon, south dodder seed, common curculigo rhizome, Chinese wolfberry, mint safflower, Chinese date, desertliving cistanche, raspberry, epimedium herb, rehmanniae vaporata and prepared tuber of multiflower knotweed are added with water and decocted by the conventional decocting method to prepare decoction; bifidus factor, zinc gluconate, citric acid and cooked white sugar are added into the dectoction; and the finished product is obtained by settling, clarifying, coarsely filtering, fining, finely filtering, stabilizing by freezing and filtering by a membrane. The product has overall health-care functions, excellent taste and high stability and adopts a simple and easy-to-implement process.