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32 results about "Serum GGTP" patented technology
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GGT is predominantly used as a diagnostic marker for liver disease. Latent elevations in GGT are typically seen in patients with chronic viral hepatitis infections often taking 12 months or more to present. Elevated serum GGT activity can be found in diseases of the liver, biliary system, and pancreas.
Process for prepering gamma-polyglutamic acid and polyglutamates
A process for preparing gamma-polyglutamic acid and polyglutamate includes such steps as culturing bacillus, such as Bacillus subtilis and lichen bacillus, in the culture medium containing carbon source, nitrogen source and Glu to obtain high-activity (1-10 U / ml) gamma-glutamyl transpeptidase, preparing high-concentration fermented liquid of gamma-polyglutamic acid, and solvent precipitation or chemical precipitation.
Owner:NANJING UNIV OF TECH
Preparing gamma-poly glutamic acid, glutamate, glutathione and its precursor with bacillus subtilis NX-2
InactiveCN1425762AImprove protectionSimple process routeBacteriaFermentationProduction rateDipeptide
The bacillus subtilis NX-2, or CGMCC NO.0833 is one bacillus spawn obtained through screening and is used for the production of gamma-polyglutamic acid and its salt as well as glutathione and its precursor. In optimized condition, gamma-polyglutamic acid may be accumulated to 30-50 g / L and produced in the production efficinecy of 0.8-2.5 g / L. When bacillus subtilis NX-2 is used in fermenting to produce gamma-glutamyl transpeptidase in optimized condition, the fermented liquid may reach enzyme activity of 1-5 U / ml; and the fermented liquid or separation obtained enzyme or the immobilized enzyme is used in the production of glutathione and its precursor with substrate dipeptide or dipeptide precursor converting rate of 30-80% being reached.
Owner:WUHAN ELITE CHEM FERTILIZER
Method for producing gamma-glutamyl transpeptidase using bacillus subtilis
InactiveCN101363014AReduce the cost of fermentation productionBacteriaTransferasesGamma-glutamyl L-dopaTryptophan
A method for producing Gamma-glutamyltranspeptidase by using Bacillus subtilis belongs to the biotechnology field of foods. The method carries out the three-stage culture of the slope, the seeds and the fermentation of the producing bacteria Bacillus subtilis SK11.004 of the Gamma-glutamyltranspeptidase; and the Gamma-glutamyltranspeptidase powder is obtained by carrying out separation and purification of fermentation broth. The provided method for producing the Gamma-glutamyltranspeptidase by using the Bacillus subtilis SK 11.004 has small breeding workload, low cost and safe and reliable performances, the method can carry out the liquid fermentation production, the cost is low, the method can be used in large-scale production, and the enzyme activity of the Gamma-glutamyltranspeptidase which is produced by using the Bacillus subtilis can be up to more than 4U / mL. The fermented product is non-toxic and can be directly used for producing a plurality of valuable Gamma-glutamyl compounds, such as L-Gamma-glutamyl-L-dopa, Gamma-glutamyl taurine, Gamma-glutamyl tryptophan, glutathione, theanine, and the like.
Owner:JIANGNAN UNIV
Fluorescent probe for detecting gamma-glutamyl transpeptidase as well as preparation method and application of fluorescent probe
InactiveCN104892541ARealize determinationVisibly pinkish purpleOrganic chemistryFluorescence/phosphorescenceOrganic solventFluorescence
Owner:INST OF CHEM CHINESE ACAD OF SCI
Dietary modulators of gamma glutamyl transpeptidase
InactiveUS20010034325A1Easy to solveEasy to adjustSenses disorderNervous disorderGamma-glutamyltransferaseBiology
The invention relates to the new compositions comprising probiotic glucoproteins and isolated soy proteins for lowering upregulated gamma glutamyl transpeptidase humans or domestic animals. Their synergetic effects with N-acetyl glucosamine is disclosed.
Owner:SLESAREV VLADIMIR I
Application of Chinese herb Pien Tze Huang and preparation thereof in preparation of drugs for treating non-alcoholic fatty liver disease (NAFLD)
InactiveCN104042655AImprove liver functionDecreased liver functionDigestive systemMammal material medical ingredientsSerum igeLiver function
The invention belongs to the field of pharmacology of Chinese medicines and discloses an application of a Chinese herb Pien Tze Huang and a preparation thereof in preparation of drugs for treating non-alcoholic fatty liver disease (NAFLD). The Chinese herb Pien Tze Huang can be used for remarkably improving the liver function of a fatty liver rat, reducing the AST (Aspartate Aminotransferase), TG (Triglyceride) and (gamma-Glutamyl Transpeptidase) level of serum, reducing the degree of fatty liver and relieving inflammatory reaction and has a remarkable curative effect on the aspect of treating NAFLD.
Owner:ZHANGZHOU PIEN TZE HUANG PHARM
Co-culture system for liver cells and Kupffer cells and application thereof
InactiveCN102220281ADoes not affect proliferationRapid cultivationMicrobiological testing/measurementArtificial cell constructsSerum glutamate pyruvate transaminaseFactor ii
The invention discloses a co-culture system for liver cells and Kupffer cells and application thereof. The co-culture system is characterized in that in a Millicell double-layer culture room, 1-100 ng / mL LPS (lipopolysaccharides) is added into a culture medium, the Kuffer cells are cultured in the upper layer of the Millicell double-layer culture room, and the liver cells are cultured in the lower layer of the Millicell double-layer culture room; and half of the fresh culture medium is replaced every other day so as to keep the concentration of the LPS. The co-culture system for liver cells and Kupffer cells provided by the invention has the advantages that the Kupffer cells continuously secrete inflammatory cell factors (such as TNF-alpha) in vitro after being stimulated by the LPS; the liver cells can generate a great number of enzymes, such as AST (aspartate aminotransferase), ALT (alanine transaminase) and GGT (gamma-glutamyl transpeptidase) in the environment so as to stimulate the liver injury based on immunoreaction caused by the immune / inflammation response after the liver tissue undergoes virus infection in vivo; and moreover, the co-culture system is used for screening medicaments resisting immune liver injury according to the influence of the medicaments on the secretion amount of immune factors and the enzymatic activity.
Owner:SHAANXI INST FOR FOOD & DRUG CONTROL
Gamma-glutamyl transpeptidase inhibitors and methods of use
InactiveUS20100197745A1High sensitivityGood effectBiocideAnimal repellantsTherapy resistantCancer cell
The present invention enhances the effects of antitumor agents and increases the sensitivity of therapy-resistant tumor cells to antitumor agents such as chemotherapeutic agents and radiation. The present invention is thus directed to compositions and methods for inhibiting and killing neoplastic cancer cells, for example for the treatment, inhibition or prevention of tumors or malignant growths or other neoplasias in mammals. The GGT inhibitor compounds used in the methods of the present invention comprise a class of benzylthiadiazol benzenesulfoniamides represented by the general structure Formula (I) (FIG. 1), or a pharmaceutically acceptable salt thereof, wherein any one or more of R1-R10 may be H, Cl, F, Br, I, OH, an alkoxy, or NO2. Other R groups include carrier groups linked by C,N, or O. The present invention also provides a method for the prophylaxis or treatment of a reversible airways obstruction in a mammal, such as a human, comprising administration of a therapeutically effective amount of a GGT inhibitor described herein for the prophylaxis or treatment of a disease associated with reverse airways obstruction such as asthma, chronic obstructive pulmonary disease (COPD), allergic reaction, respiratory tract infection or upper respiratory tract disease. Other diseases or conditions which may be treated include, for example, degenerative diseases, renal diseases, liver diseases, and inner ear conditions or diseases.
Owner:THE BOARD OF RGT UNIV OF OKLAHOMA
Control technical system for important metabolic disease of dairy cattle after delivery
The present invention relates to a control technical system for important metabolic disease of dairy cattle after delivery, belonging to the technical field of veterinary medicine. The technical system is used for controlling and preventing important metabolic diseases of dairy cattle after delivery by detecting dairy cattle before and after delivery in the aspects of dietary cation anion balance (DCAB), oxidation resistance capability of cow plasma (glutathione peroxidase GSH-Px, superoxide dismutase SOD, methylene dioxyamphetamine MDA), plasma leptin hormone levels, liver function indexes (ornithine carbamoyl transferase OCT, aspartate transaminease AST, gamma-glutamyl transpeptidase GGT, total bilirubin Tbil, total protein TP, albumin ALB), blood biochemical indexes (acetone bodies, nonesterified fatty acid NEFA, lactic acid, blood sugar, blood fat, triglyceride TG, total cholesterol TC, calcium, phosphorus and magnesium), cow appetite, milk output increase speed, etc. The important metabolic diseases include cow parturient paresis, retention of afterbirth, endometritis, ketosis, ruminant acidosis, mastitis and fatty liver. The present invention is suitable for preventing and controlling metabolic diseases of dairy cattle after delivery in large-scale dairy farms.
Owner:何宝祥 +2
MALDI-TOF mass spectrometric probe for gamma-glutamyl transpeptidase detection and use method thereof
ActiveCN108424436AEasy to synthesizeStable under mass spectrometry conditionsMicrobiological testing/measurementBiological material analysisLysosomeStructural formula
The invention relates to an MALDI-TOF mass spectrometric probe for gamma-glutamyl transpeptidase detection and a use method thereof. The structural formula of the probe is shown as the specification.The probe is used for quantitative analysis of GGT enzyme and screening of related inhibitor drugs, compared with the prior art, the molecular probe synthesis cost and labor force are reduced, the interference of substrate light signal, light scattering, photobleaching and other phenomena in the spectrum can be avoided, rapid and accurate analysis of GGT enzyme in cell lysosomes and human serum can be achieved, simultaneous analysis of hundreds of samples on an MALDI target plate can be realized, and the analysis speed and efficiency are greatly improved.
Owner:JILIN UNIV
Strong-taste peptide, strong-taste endowing agent, seasoning and preparation method of strong-taste peptide
InactiveCN107114752AHas savory propertiesPeptides with abnormal peptide linkFood scienceGlutaminaseValine
The invention discloses strong-taste peptide, a strong-taste endowing agent, seasoning and a preparation method of the strong-taste peptide. The strong-taste peptide (gamma-Glu-gamma-Glu-gamma-Glu-gamma-Glu-val) disclosed by the invention has favorable stability, and can significantly improve the strong taste of foods particularly condiments under the concentration of 20-100mg / kg. The preparation method comprises the specific preparation steps of mixing glutamine with valine to obtain a mixture, dissolving the mixture in water to obtain a solution, adding glutaminase of which the mass is 0.001-0.4%(w / w) of that of the solution or gamma-glutamyl transpeptidase of which the mass is 0.001-0.4%(w / w) of that of the solution, regulating the pH of the solution to be 8.0-10.0 with a 10mol / l sodium hydroxide solution, performing a reaction at 25-50 DEG C for 3-12 hours, then regulating the pH of the solution back to be 6-7 with 4 mol / l hydrochloric acid, and performing enzyme deactivation at 90 DEG C for 10min.
Owner:SOUTH CHINA UNIV OF TECH
Multifunctional lactobacillus buchneri CCFM1053 for relieving PFOA toxic action as well as fermented food and application thereof
The invention discloses multifunctional lactobacillus buchneri CCFM1053 for relieving PFOA toxic action as well as fermented food and application thereof. The lactobacillus buchneri CCFM1053 can adsorb PFOA, improve spleen atrophy caused by PFOA exposure, increase content of TNA-alpha in serum after PFOA exposure, increase content of glutamic-pyruvic transaminase, glutamic oxalacetic transaminaseand gamma-glutamyl transpeptidase in serum in mice after PFOA exposure, reduce the content of MDA in liver after PFOA exposure to the normal level, reduce GAH activity, improve intestinal flora disorder, reduce hepatopathy, improve excrement moisture content and first melena discharge time of constipation patients, relieve constipation, improve proliferation of INS-1 cells and expression of MafA genes under the high glucose action and relieve PFOA related diabetes mellitus.
Owner:JIANGNAN UNIV
Supplementary strategy for improving catalytic synthesis of L-theanine from gamma-glutamyl transpeptidase
InactiveCN104789538AAvoid inhibitionImprove conversion rateMicroorganism based processesAcyltransferasesL-theanineL-Glutamin
The invention discloses to further optimization of a process for generating L-theanine from L-glutamine and ethylamine catalyzed by gamma-glutamyl transpeptidase secreted from recombinant pMA5-ggt / Bacillus. subtilis by using a method that double substrates are added in different batches, and belongs to the field of fermentation engineering and enzyme engineering. The process comprises the following steps: culturing the strain of bacillus subtilis which is established in previous operation and is used for secreting gamma-glutamyl transpeptidase in a fermentation tank; concentrating supernate crude enzyme liquid for conversion of theanine; on the basis, adding the substrates in different batches so as to further regulate and control the conversion process, that is, in a reaction system with 60U / mL of the enzyme liquid, adding substrates glutamine and ethylamine into the system every other two hours, wherein the addition amount of glutamine is fixed to be 20 mM, the ratio of a donor to a receptor is controlled to be 1:12, the pH value is adjusted to be 10, 164.2 mM of theanine can be obtained after 18 hours, and the conversion rate of glutamine can be up to 91.2%. The method has the advantages that the operation is simple, the cost is low, the yield of theanine is high, the substrate conversion rate is high, and the like, and is beneficial for industrial large-scale production.
Owner:JIANGNAN UNIV
Process for the enzymatic preparation of a gamma-glutamyl compound
Disclosed is a process for the enzymatic preparation of a gamma-glutamyl compound. The process comprises a step of contacting a gamma-glutamyl donor and a gamma-glutamyl acceptor with an aqueous medium comprising a gamma glutamyl transpeptidase enzyme. The enzyme is derived from a plant belonging to the Graminaceae or Leguminaceae family, or from Camellia sinensis.
Owner:CONOPCO INC D B A UNILEVER
Preparing gamma-poly glutamic acid, glutamate, glutathione and its precursor with bacillus subtilis NX-2
InactiveCN1164737CImprove protectionSimple process routeBacteriaFermentationProduction rateDipeptide
The bacillus subtilis NX-2, or CGMCC NO.0833 is one bacillus spawn obtained through screening and is used for the production of gamma-polyglutamic acid and its salt as well as glutathione and its precursor. In optimized condition, gamma-polyglutamic acid may be accumulated to 30-50 g / L and produced in the production efficinecy of 0.8-2.5 g / L. When bacillus subtilis NX-2 is used in fermenting to produce gamma-glutamyl transpeptidase in optimized condition, the fermented liquid may reach enzyme activity of 1-5 U / ml; and the fermented liquid or separation obtained enzyme or the immobilized enzyme is used in the production of glutathione and its precursor with substrate dipeptide or dipeptide precursor converting rate of 30-80% being reached.
Owner:WUHAN ELITE CHEM FERTILIZER
Gamma glutamyl transpeptidase inhibitors and methods of use
ActiveUS8741937B2High sensitivityGood effectBiocideOrganic chemistryTranspeptidase InhibitorsCancer cell
Owner:THE BOARD OF RGT UNIV OF OKLAHOMA
Strong-taste peptide, strong-taste endowing agent, seasoning and preparation method of strong-taste peptide
The invention discloses strong-taste peptide, a strong-taste endowing agent, seasoning and a preparation method of the strong-taste peptide. The strong-taste peptide (gamma-Glu-gamma-Glu-gamma-Glu-gamma-Glu-val) disclosed by the invention has favorable stability, and can significantly improve the strong taste of foods particularly condiments under the concentration of 20-100mg / kg. The preparation method comprises the specific preparation steps of mixing glutamine with valine to obtain a mixture, dissolving the mixture in water to obtain a solution, adding glutaminase of which the mass is 0.001-0.4%(w / w) of that of the solution or gamma-glutamyl transpeptidase of which the mass is 0.001-0.4%(w / w) of that of the solution, regulating the pH of the solution to be 8.0-10.0 with a 10mol / l sodium hydroxide solution, performing a reaction at 25-50 DEG C for 3-12 hours, then regulating the pH of the solution back to be 6-7 with 4 mol / l hydrochloric acid, and performing enzyme deactivation at 90 DEG C for 10min.
Owner:SOUTH CHINA UNIV OF TECH
Sweet taste peptide as well as preparation method and application thereof
InactiveCN108794573AHas sweet peptide propertiesImprove stabilityPeptide preparation methodsFermentationSucroseGlutaminase
The invention discloses a sweet taste peptide as well as a preparation method and application thereof. The preparation method specifically comprises the steps as follows: mixing L-glutamine with D-valine and dissolving in water, adding glutaminase or gamma-glutamyl transpeptidase with the mass being 0.001-0.4% (w / w) of the solution mass, adjusting the pH of the solution to 8.0-10.0 with a 10 mol / lsodium hydroxide solution, allowing a reaction at 25-50 DEG C for 3-12 h, then adjusting the pH back to 6-7 with 4 mol / L hydrochloric acid, and performing enzyme denaturing at 90 DEG C for 10 min. The gamma-glutamine peptide (gamma-L-Glu-gamma-L-Glu-gamma-L-Glu-gamma-L-Glu-D-Val) prepared by the invention is good in stability and has a natural sweet taste similar to that of sucrose.
Owner:GUANGDONG POLYTECHNIC OF ENVIRONMENTAL PROTECTION ENG
Fluorescent probe for detecting high-concentration gamma-Glutamyl Transpeptidase and preparation method thereof
ActiveCN108893106AGood luminous propertiesThe synthesis process is simplePeptide preparation methodsGroup 3/13 element organic compoundsHigh concentrationFluorescence
The invention provides a fluorescent probe for detecting high-concentration gamma-Glutamyl Transpeptidase, which solves the problem of selective response to abnormally high-concentration gamma-Glutamyl Transpeptidase in vivo. The fluorescent probe of the invention starts to produce obvious fluorescence changes after the gamma-Glutamyl Transpeptidase is higher than the normal concentration of humanbody, and as the concentration of gamma-Glutamyl Transpeptidase increases, the fluorescent probe solution of the invention produces large fluorescence enhancement and obvious color change. At the same time, after the fluorescent probe of the invention reacts with gamma-Glutamyl Transpeptidase, the permeability of the cell membrane is greatly enhanced, and when applied to cell imaging, the fluorescent probe can selectively image ovarian cancer cells with high expression of gamma-Glutamyl Transpeptidase. According to the invention, the synthesis process is simple and feasible, the raw materialsare cheap and easy to obtain, the preparation cost is low, and the preparation method is easy to popularize.
Owner:川北医学院
A compound, a product containing the compound and applications in detection of gamma-glutamyl transpeptidase
ActiveCN110204476AHigh sensitivityReduce distractionsGroup 5/15 element organic compoundsColor/spectral properties measurementsGamma-glutamyltransferaseOrganic chemistry
Owner:FUDAN UNIV +1
Gamma-glutamyl transpeptidase inhibitors and methods of use
ActiveUS20130085168A1High sensitivityGood effectBiocideOrganic chemistryCancer cellTranspeptidase Inhibitors
Compositions and methods for inhibiting human gamma-glutamyl transpeptidase (GGT) in vivo or in vitro and for inhibiting and killing neoplastic cancer cells, for example for the treatment, inhibition or prevention of tumors or malignant growths or other neoplasias in mammals, or sensitizing tumor to other therapies including radiation therapy. The GGT inhibitor compounds comprise a class of benzylthiadiazol benzenesulfoniamides. The compounds may also be used to treat a reversible airways obstruction in a mammal or a disease associated with reverse airways obstruction such as asthma, chronic obstructive pulmonary disease (COPD), allergic reaction, respiratory tract infection or upper respiratory tract disease. Other diseases or conditions which may be treated include, for example, degenerative diseases, renal diseases, liver diseases, cardiovascular disease and inner ear conditions or diseases.
Owner:THE BOARD OF RGT UNIV OF OKLAHOMA
Enzymatic conversion preparation method of gamma-L-glutamoyl n-propylamine
InactiveCN108588138AIncrease catalytic rateIncrease speedAcyltransferasesFermentationEnzymatic synthesisPropylamine
The invention provides an enzymatic conversion preparation method of gamma-L-glutamoyl n-propylamine. The method comprises the following steps: carrying out culture and fermentation on a strain with the activity of gamma-glutamyl transpeptidase in a culture medium, and carrying out centrifugalizing on the fermentation liquid, thus obtaining the wet thallus containing gamma-glutamyl transpeptidase;(2) adding conversion liquid into the wet thallus, carrying out enzymatic reaction under the condition with the temperature being 35-50 DEG C and the pH being 6-11, and carrying out separation by adopting an isoelectric point crystallization method, thus obtaining gamma-L-glutamoyl n-propylamine, wherein the conversion liquid contains L-glutamic acid-gamma-methyl ester, n-propylamine, and one ofethyl acetate, butyl acetate, octanol and n-hexanol. According to the method, the specific strain of gamma-glutamyl transpeptidase is cultured in the culture medium, gamma-glutamyl transpeptidase is efficiently expressed, so that the enzymatic synthesis of gamma-L-glutamoyl n-propylamine has relatively high catalysis rate and conversion rate, in addition, the reaction conditions are mild, the stereoselectivity of enzyme is strong, the catalysis efficiency is high, the cost is low, the technical process is simple, and the method is suitable for industrial production.
Owner:宿州学院
Oligopeptide, strong taste imparting agent, seasoner, and preparation method and application of oligopeptide
InactiveCN107118258AHas savory propertiesPeptide preparation methodsFood scienceGlutaminaseGamma-glutamyltransferase
The invention discloses oligopeptide, a strong taste imparting agent, a seasoner, and a preparation method and application of oligopeptide. The oligopeptide gamma-Glu-gamma-Glu-Abu has favorable stability, can remarkably improve the strong taste of food, particularly the seasoner, under the concentration of 60-100 mg / kg. The preparation method particularly comprises the following steps: mixing glutamine with 2-aminobutyric acid; dissolving the mixture into water; adding glutaminase or gamma-glutamyl transpeptidase with the solution mass of 0.001-0.4% (w / w); adjusting the pH of the solution to be 7.0-10.0 by use of a 10 mol / l sodium hydroxide solution; enabling reaction for 3-12 h at 25-50 DEG C; adjusting the pH back to 7-8 by use of 4 mol / L hydrochloric acid; and performing enzyme deactivation for 10 min at 90 DEG C.
Owner:SOUTH CHINA UNIV OF TECH
Use of reservatrol for the treatment of non-alcoholic fatty liver disease (NAFLD)
ActiveUS20190209488A1Reduce fatImprove antioxidant capacityHydroxy compound active ingredientsDigestive systemInsulin resistanceHepatic enzyme
Micronized trans-resveratrol is provided in 50-200 mg unit dosage form for use as a single unit dose daily for administration to human patients the treatment or prevention of non-alcoholic fatty liver disease and / or for the treatment, prevention or reversal of non-alcoholic hepatic steatosis, e.g. for administration to patients exhibiting evidence of fatty liver on ultrasonography. A reported study shows the effects of resveratrol micronized formulation in reducing the liver fat, decreasing hepatic enzymes, serum glutamate pyruvic transaminase (SGPT) and gamma-glutamyl transpeptidase (g-GT) and decreasing insulin resistance. At the end of the study, statistical analysis showed a strongly statistically significant reduction in the liver fat, which in some patients continued for an extended period after treatment was discontinued. These results demonstrate that use of resveratrol in micronized formulation improves features of NAFLD, prevents liver damage and that resveratrol micronized formulation can be an effective treatment for NAFLD.
Owner:THEODOTOU MARIOS ANDREOU
Liuwei Anxiao pharmaceutical composition and application of preparation thereof in preparation of drug for treating alcoholic hepatitis
ActiveCN103599449ASignificant effectWide range of clinical applicationsDigestive systemAluminium/calcium/magnesium active ingredientsAlanine aminotransferaseClinical tests
The invention discloses a Liuwei Anxiao pharmaceutical composition and application of a preparation thereof in preparation of a drug for treating alcoholic hepatitis. The Liuwei Anxiao pharmaceutical composition comprises six medicine ingredients, namely, Tibet inula root, rheum officinale, rhizoma kaempferiae, fumed gypsum, fructus chebulae and tronae. The clinical test shows that the Liuwei Anxiao pharmaceutical composition can protect alcoholic liver injury and can also obviously improve AST (Aspartate Transaminase), ALT (Alanine Aminotransferase), GGT (Gamma Glutamyl Transpeptidase), TBiL (Total Bilirubin) and other biochemical indexes.
Owner:JINKE TIBETAN MEDICINE QINGHAI PROV
Application of Liuwei Anxiao pharmaceutical composition and its preparation in the preparation of drugs for treating alcoholic hepatitis
ActiveCN103599449BSignificant effectWide range of clinical applicationsDigestive systemAluminium/calcium/magnesium active ingredientsAdditive ingredientAlanine aminotransferase
The invention discloses the application of Liuwei Anxiao pharmaceutical composition and its preparation in the preparation of drugs for treating alcoholic hepatitis. It is composed of six herbs such as seed and alkali flower. Clinical trials have shown that the Liuweian Xiaosan pharmaceutical composition has a protective effect on alcoholic liver injury, and can significantly improve biochemical indicators such as AST, ALT, GGT, and TBiL. <pb pnum="1" / >
Owner:JINKE TIBETAN MEDICINE QINGHAI PROV
Co-culture system for liver cells and Kupffer cells and application thereof
InactiveCN102220281BDoes not affect proliferationRapid cultivationMicrobiological testing/measurementArtificial cell constructsSerum glutamate pyruvate transaminaseIn vivo
Owner:SHAANXI INST FOR FOOD & DRUG CONTROL
Method to characterize a protein as RNA binding protein
InactiveUS20110040545A1Analogue computers for chemical processesMaterial analysisProtein modellingBinding site
The invention relates to a method to characterize a protein as RNA-binding protein, said method comprising steps of: a) modeling the protein using a template structure; b) analyzing the modeled protein for RNA-binding site(s); and c) docking the analyzed modeled protein with polyadenylated RNA using co-ordinates of RNA complexed with polyadenide binding for said chacterisation. The invention especially relates to a method to characterize Gamma-glutamyl transpeptidase (GGT) as RNA-binding protein, said method comprising steps of: a) modeling the GGT using a template structure; b) analyzing the modeled GGT for RNA-binding site(s); and c) docking the analyzed modeled GGT with polyadenylated RNA using coordinates of RNA complexed with polyadenide protein for said characterisation.
Owner:POLYCLONE BIOSERVICES PVT
Method for producing gamma-glutamyl transpeptidase using bacillus subtilis
InactiveCN101363014BReduce the cost of fermentation productionBacteriaTransferasesGamma-glutamyl L-dopaTheanine
A method for producing Gamma-glutamyltranspeptidase by using Bacillus subtilis belongs to the biotechnology field of foods. The method carries out the three-stage culture of the slope, the seeds and the fermentation of the producing bacteria Bacillus subtilis SK11.004 of the Gamma-glutamyltranspeptidase; and the Gamma-glutamyltranspeptidase powder is obtained by carrying out separation and purification of fermentation broth. The provided method for producing the Gamma-glutamyltranspeptidase by using the Bacillus subtilis SK 11.004 has small breeding workload, low cost and safe and reliable performances, the method can carry out the liquid fermentation production, the cost is low, the method can be used in large-scale production, and the enzyme activity of the Gamma-glutamyltranspeptidase which is produced by using the Bacillus subtilis can be up to more than 4U / mL. The fermented product is non-toxic and can be directly used for producing a plurality of valuable Gamma-glutamyl compounds, such as L-Gamma-glutamyl-L-dopa, Gamma-glutamyl taurine, Gamma-glutamyl tryptophan, glutathione, theanine, and the like.
Owner:JIANGNAN UNIV
Method of judging the onset of periodontitis
InactiveCN1813189AMicrobiological testing/measurementDisease diagnosisGingival Crevicular FluidsDental plaque induced gingivitis
The present invention provides a method of gingivitis and periodontitis which are distingushed simply. The inventor discovered that gamma-GTP (gamma-glutamyl transpeptidase) was scarcely contained in the gingival crevicular fluid of patients with gingivitis, but was contained in the gingival crevicular fluid of patients with periodontitis. Thus, the inventor provides a determination method of development of periodontitis by detecting or measuring gamma-GTP contained in the gingival crevicular fluid. Also, this method can be applied to the determination of the development of peri-implant inflammation.
Owner:APPL CELL BIOTECHNOLOGIES INC
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