The invention relates to a system and method for grinding a part weld joint based on a vision guide robot. The system comprises a laser sensor, an image collection module, an upper computer, the robot and a floating grinding head. The laser sensor, the image collection module and the floating grinding head are mounted on the sixth-axis tail end of the robot, the laser sensor is used for collecting the relative position of the robot and a part, the image collection module is used for collecting image information of the part at the specific position, and the upper computer is used for processing the image information so as to determine the weld joint position, and controlling the robot to drive the floating grinding head to grind the weld joint. According to the system, the laser sensor carries out automatic positioning of the collected image, accuracy and uniqueness of the image collecting position each time can be ensured, the system can achieve full-automatic grinding, the work efficiency is high, operation is concise, worker operation is facilitated, the ground product quality is ensured, and efficient and high-quality production of the enterprise is facilitated.