The invention discloses ultrahigh toughness steel plate for deep-water pressure resistant shell and manufacture method thereof. The steel plate comprises (by wt%) C 0.05-0.09, Si less than or equal to 0.10, Mn 0.45-0.95, P less than or equal to 0.012, S less than or equal to 0.0030, Cr 0.40-0.80, Mo 0.40-0.80, Ni 3.50-5.50, Cu 0.20-0.50, Ti 0.003-0.010, Als 0.010-0.030, V 0.040-0.080, N less than or equal to 0.0060, O less than or equal to 0.0030, Ca 0.001-0.004, and Fe and unavoidable impurity in balance. The method adopts optimized TMCP and offline quenching and tempering (QT) process, endows microscopic structure of product steel plate with fine low carbon tempered martensite and small amount of tempered bainite, with average packet size smaller than 15 Mum, solves the problem of overquenching of ultrahigh strength steel plate surface, and is especially suitable for use in hydroelectric pressure water pipe and steel yoke pipe of ultrahigh water head (greater than or equal to 1,200 m) power station, and polar ocean platform and deep-water pressure resistant shell.